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Academic Journal

Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner.

  • Authors : Cheng XS; Department of Neurology, Translational Medicine Center, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, Henan, China.; Department of Pathophysiology, Key Laboratory of Neurological Disease of National Education Ministry and Hubei Province, Institute for Brain Research, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.

Subjects: ADAM10 Protein*/ADAM10 Protein*/ADAM10 Protein*/genetics ; ADAM10 Protein*/ADAM10 Protein*/ADAM10 Protein*/metabolism ; AMP-Activated Protein Kinases*/AMP-Activated Protein Kinases*/AMP-Activated Protein Kinases*/genetics

  • Source: Aging [Aging (Albany NY)] 2021 Oct 13; Vol. 13 (20), pp. 23620-23636. Date of Electronic Publication: 2021 Oct 13.Publisher: Impact Journals, LLC Country of Publication: United States NLM ID: 101508617 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking.

  • Authors : Paumier JM; Aix-Marseille Univ, CNRS, INP, Inst Neurophysiopathol, Marseille, France; and.

Subjects: Amyloid/Amyloid/Amyloid/*chemistry ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism

  • Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Feb; Vol. 33 (2), pp. 2910-2927. Date of Electronic Publication: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic

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Academic Journal

Carbon monoxide attenuates amyloidogenesis via down-regulation of NF-κB-mediated BACE1 gene expression.

  • Authors : Kim HJ; Meta-Inflammation Research Institute of Basic Research, School of Biological Sciences, University of Ulsan, Ulsan, South Korea.; Joe Y

Subjects: Amyloid/Amyloid/Amyloid/*biosynthesis ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*genetics ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*genetics

  • Source: Aging cell [Aging Cell] 2019 Feb; Vol. 18 (1), pp. e12864. Date of Electronic Publication: 2018 Nov 09.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants.

Subjects: Amyloid*/Amyloid*/Amyloid*/blood ; Amyloid*/Amyloid*/Amyloid*/metabolism ; Genome-Wide Association Study*

  • Source: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2021 Oct; Vol. 17 (10), pp. 1663-1674. Date of Electronic Publication: 2021 May 18.Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Compound CID 9998128 Is a Potential Multitarget Drug for Alzheimer's Disease.

  • Authors : Thai NQ; Institute for Computational Sciences and Technology , SBI building, Quang Trung Software City , Tan Chanh Hiep Ward, District 12, Ho Chi Minh City , Vietnam.; Dong Thap University , 783 Pham Huu Lau Street, Ward 6 , Cao Lanh City , Dong Thap , Vietnam.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Amyloid/Amyloid/Amyloid/*drug effects ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*drug effects

  • Source: ACS chemical neuroscience [ACS Chem Neurosci] 2018 Nov 21; Vol. 9 (11), pp. 2588-2598. Date of Electronic Publication: 2018 Jun 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions.

  • Authors : Hu X; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH .; Das B

Subjects: Cognition* ; Gene Deletion*; Amyloid/Amyloid/Amyloid/*metabolism

  • Source: The Journal of experimental medicine [J Exp Med] 2018 Mar 05; Vol. 215 (3), pp. 927-940. Date of Electronic Publication: 2018 Feb 14.Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein.

  • Authors : Park J; School of Pharmacy, Sungkyunkwan University, Suwon, Korea.; Department of Health Science and Technology, Sungkyunkwan University, Seoul, Korea.

Subjects: Amyloid/Amyloid/Amyloid/*biosynthesis ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*physiology ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*physiology

  • Source: The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2021 Jan 01; Vol. 76 (1), pp. 23-31.Publisher: published on behalf of the Gerontological Society of America by Oxford University Press Country of Publication: United States NLM ID: 9502837

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Academic Journal

Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats.

  • Authors : Safar MM; Pharmacology and Toxicology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt; Pharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt, Cairo, Egypt.

Subjects: Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects; Amyloid/Amyloid/Amyloid/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism

  • Source: Chemico-biological interactions [Chem Biol Interact] 2020 Sep 01; Vol. 328, pp. 109144. Date of Electronic Publication: 2020 Jul 09.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786

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Academic Journal

Iron Dyshomeostasis Induces Binding of APP to BACE1 for Amyloid Pathology, and Impairs APP/Fpn1 Complex in Microglia: Implication in Pathogenesis of Cerebral Microbleeds.

  • Authors : Gong L; 1 Department of Neurology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.; Li Gong, Jing Zhou and Xiangzhu Tian contributed equally to this article.

Subjects: Homeostasis*; Amyloid/Amyloid/Amyloid/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism

  • Source: Cell transplantation [Cell Transplant] 2019 Aug; Vol. 28 (8), pp. 1009-1017. Date of Electronic Publication: 2019 Feb 18.Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9208854 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

  • Authors : Rochin L; Institut Curie, and Unité Mixte de Recherche 144, Centre National de la Recherche Scientifique, F-75248 Paris, France.; Hurbain I

Subjects: Amyloid/Amyloid/Amyloid/*biosynthesis ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jun 25; Vol. 110 (26), pp. 10658-63. Date of Electronic Publication: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  248 results for ""Amyloid Precursor Protein Secretases""