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Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects.

• Authors : Patat A; Biotrial, Rennes, France.; Parks V

Subjects: Serotonin 5-HT1 Receptor Antagonists*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Dioxanes/Dioxanes/Dioxanes/*adverse effects

• Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2009 Mar; Vol. 67 (3), pp. 299-308.Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print Cited Medium: Internet ISSN: 1365-2125

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A positron emission tomography study to assess binding of lecozotan, a novel 5-hydroxytryptamine-1A silent antagonist, to brain 5-HT1A receptors in healthy young and elderly subjects, and in patients with Alzheimer's disease.

• Authors : Raje S; Wyeth Research, Early Development and Clinical Pharmacology, Collegeville, Pennsylvania, USA. ; Patat AA

Subjects: Positron-Emission Tomography*; Aging/Aging/Aging/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism

• Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2008 Jan; Vol. 83 (1), pp. 86-96. Date of Electronic Publication: 2007 May 16.Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535

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Non-adrenoceptor [3H]idazoxan binding sites (I2-imidazoline sites) are increased in postmortem brain from patients with Alzheimer's disease.

• Authors : Ruiz J; Department of Pharmacology, University of the Basque Country, Leioa, Spain.; Martín I

Subjects: Adrenergic alpha-Antagonists/Adrenergic alpha-Antagonists/Adrenergic alpha-Antagonists/*metabolism ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Dioxanes/Dioxanes/Dioxanes/*metabolism

• Source: Neuroscience letters [Neurosci Lett] 1993 Sep 17; Vol. 160 (1), pp. 109-12.Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print Cited Medium: Print ISSN:

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Modulation of hippocampal excitability by 5-HT4 receptor agonists persists in a transgenic model of Alzheimer's disease.

• Authors : Spencer JP; Neurology and GI CEDD, GlaxoSmithKline, Harlow, Essex CM19 5AW, UK. ; Brown JT

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*physiopathology ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*genetics ; Hippocampus/Hippocampus/Hippocampus/*metabolism

• Source: Neuroscience [Neuroscience] 2004; Vol. 129 (1), pp. 49-54.Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print Cited Medium: Print ISSN: 0306-4522

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Agricola

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