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Academic Journal

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles.

  • Authors : Stojan J; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Pesaresi A

Subjects: Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/chemistry ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/metabolism ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/pharmacology

  • Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 May; Vol. 33 (5), pp. e4977.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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Academic Journal

A-series agent A-234: initial in vitro and in vivo characterization.

  • Authors : Hrabinova M; University of Defence, Military Faculty of Medicine, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Králové, Czech Republic.; Pejchal J

Subjects: Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology ; Pralidoxime Compounds*; Taurine/Taurine/Taurine/*analogs & derivatives

  • Source: Archives of toxicology [Arch Toxicol] 2024 Apr; Vol. 98 (4), pp. 1135-1149. Date of Electronic Publication: 2024 Mar 06.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Pralidoxime Is no Longer Fit for Purpose as an Antidote to Organophosphate Poisoning in the United Kingdom.

  • Authors : Corby G; St John's College, University of Oxford, Oxford, UK.

Subjects: Organophosphate Poisoning*/Organophosphate Poisoning*/Organophosphate Poisoning*/drug therapy ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/therapeutic use ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology

  • Source: Disaster medicine and public health preparedness [Disaster Med Public Health Prep] 2024 Feb 22; Vol. 18, pp. e32. Date of Electronic Publication: 2024 Feb 22.Publisher: Cambridge University Press Country of Publication: United States NLM ID: 101297401 Publication Model: Electronic Cited Medium: Internet

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Academic Journal

A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate.

  • Authors : Pirollo KF; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20057, USA.; Moghe M

Subjects: Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/toxicity ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/chemistry

  • Source: International journal of nanomedicine [Int J Nanomedicine] 2024 Jan 12; Vol. 19, pp. 307-326. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Acute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits.

  • Authors : Urquizu E; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacology Section and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain.; Paratusic S

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects ; Paraoxon*/Paraoxon*/Paraoxon*/toxicity ; Memory Disorders*/Memory Disorders*/Memory Disorders*/metabolism

  • Source: International journal of molecular sciences [Int J Mol Sci] 2024 Nov 14; Vol. 25 (22). Date of Electronic Publication: 2024 Nov 14.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067

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Academic Journal

Synthesis and in vitro assessment of the reactivation profile of clinically available oximes on the acetylcholinesterase model inhibited by A-230 nerve agent surrogate.

  • Authors : Bernardo LB; Instituto Militar de Engenharia (IME), Praça General Tibúrcio 80, Rio de Janeiro, RJ, 22290-270, Brazil. .; Instituto de Defesa Química, Biológica, Radiológica e Nuclear (IDQBRN), Centro Tecnológico do Exército (CTEx), Avenida das Américas 28705, Área 4, Rio de Janeiro, RJ, 23020-470, Brazil. .

Subjects: Oximes*/Oximes*/Oximes*/pharmacology ; Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/metabolism ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology

  • Source: Archives of toxicology [Arch Toxicol] 2024 Oct; Vol. 98 (10), pp. 3397-3407. Date of Electronic Publication: 2024 Jul 14.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Oxime-functionalized anti-insecticide fabric reduces insecticide exposure through dermal and nasal routes, and prevents insecticide-induced neuromuscular-dysfunction and mortality.

  • Authors : Mohan MK; Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem), GKVK Post, Bellary Road, Bangalore, 560065, Karnataka, India.; Thorat K

Subjects: Insecticides*/Insecticides*/Insecticides*/toxicity ; Oximes*/Oximes*/Oximes*/administration & dosage ; Oximes*/Oximes*/Oximes*/pharmacology

  • Source: Nature communications [Nat Commun] 2024 Jun 06; Vol. 15 (1), pp. 4844. Date of Electronic Publication: 2024 Jun 06.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN:

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Academic Journal

Preferential Door for Ligand Binding and Unbinding Pathways in Inhibited Human Acetylcholinesterase.

  • Authors : Kongkaew N; Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, 10330, Thailand.; Hengphasatporn K

Subjects: Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/metabolism ; Acetylcholinesterase*/Acetylcholinesterase*/Acetylcholinesterase*/chemistry ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/chemistry

  • Source: The journal of physical chemistry letters [J Phys Chem Lett] 2024 May 30; Vol. 15 (21), pp. 5696-5704. Date of Electronic Publication: 2024 May 20.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101526034 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Pharmacokinetics and pharmacodynamics of standard nerve agent medical countermeasures in Göttingen Minipigs.

  • Authors : Langston JL; United States Army Medical Research Institute of Chemical Defense, Medical Toxicology Research Division, Pharmaceutical Sciences Department, Aberdeen Proving Ground, MD 21010-5400, USA.; Moffett MC

Subjects: Swine, Miniature* ; Diazepam*/Diazepam*/Diazepam*/pharmacokinetics ; Diazepam*/Diazepam*/Diazepam*/pharmacology

  • Source: Toxicology letters [Toxicol Lett] 2024 Jun; Vol. 397, pp. 103-116. Date of Electronic Publication: 2024 May 03.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.

  • Authors : Zhao D; State Key Laboratory of Chemical Resource Engineering, Institute of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China.; Liu J

Subjects: Metal-Organic Frameworks/Metal-Organic Frameworks/Metal-Organic Frameworks/*chemistry ; Nerve Agents/Nerve Agents/Nerve Agents/*pharmacology ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*pharmacology

  • Source: Inorganic chemistry [Inorg Chem] 2022 Jan 24; Vol. 61 (3), pp. 1512-1520. Date of Electronic Publication: 2021 Dec 30.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet

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  • 1-10 of  1,378 results for ""Pralidoxime Compounds""