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Academic Journal

Disentangling the formation, mechanism, and evolvement of the covalent methanesulfonyl fluoride acetylcholinesterase adduct: Insights into an aged-like inactive complex susceptible to reactivation by a combination of nucleophiles.

  • Authors : Stojan J; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.; Pesaresi A

Subjects: Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/chemistry ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/metabolism ; Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/pharmacology

  • Source: Protein science : a publication of the Protein Society [Protein Sci] 2024 May; Vol. 33 (5), pp. e4977.Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet

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A-series agent A-234: initial in vitro and in vivo characterization.

  • Authors : Hrabinova M; University of Defence, Military Faculty of Medicine, Department of Toxicology and Military Pharmacy, Trebesska 1575, 500 01, Hradec Králové, Czech Republic.; Pejchal J

Subjects: Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology ; Pralidoxime Compounds*; Taurine/Taurine/Taurine/*analogs & derivatives

  • Source: Archives of toxicology [Arch Toxicol] 2024 Apr; Vol. 98 (4), pp. 1135-1149. Date of Electronic Publication: 2024 Mar 06.Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Pralidoxime Is no Longer Fit for Purpose as an Antidote to Organophosphate Poisoning in the United Kingdom.

  • Authors : Corby G; St John's College, University of Oxford, Oxford, UK.

Subjects: Organophosphate Poisoning*/Organophosphate Poisoning*/Organophosphate Poisoning*/drug therapy ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/therapeutic use ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology

  • Source: Disaster medicine and public health preparedness [Disaster Med Public Health Prep] 2024 Feb 22; Vol. 18, pp. e32. Date of Electronic Publication: 2024 Feb 22.Publisher: Cambridge University Press Country of Publication: United States NLM ID: 101297401 Publication Model: Electronic Cited Medium: Internet

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A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate.

  • Authors : Pirollo KF; Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, 20057, USA.; Moghe M

Subjects: Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/Cholinesterase Inhibitors*/toxicity ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/pharmacology ; Cholinesterase Reactivators*/Cholinesterase Reactivators*/Cholinesterase Reactivators*/chemistry

  • Source: International journal of nanomedicine [Int J Nanomedicine] 2024 Jan 12; Vol. 19, pp. 307-326. Date of Electronic Publication: 2024 Jan 12 (Print Publication: 2024).Publisher: DOVE Medical Press Country of Publication: New Zealand NLM ID: 101263847 Publication Model: eCollection Cited Medium: Internet ISSN:

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Academic Journal

Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents.

  • Authors : Zhao D; State Key Laboratory of Chemical Resource Engineering, Institute of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China.; Liu J

Subjects: Metal-Organic Frameworks/Metal-Organic Frameworks/Metal-Organic Frameworks/*chemistry ; Nerve Agents/Nerve Agents/Nerve Agents/*pharmacology ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*pharmacology

  • Source: Inorganic chemistry [Inorg Chem] 2022 Jan 24; Vol. 61 (3), pp. 1512-1520. Date of Electronic Publication: 2021 Dec 30.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet

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Surface modification of pralidoxime chloride-loaded solid lipid nanoparticles for enhanced brain reactivation of organophosphorus-inhibited AChE: Pharmacokinetics in rat.

  • Authors : Buzyurova DN; Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov St., 8, Kazan, 420088, Russia.; Pashirova TN

Subjects: Antidotes/Antidotes/Antidotes/*administration & dosage ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*toxicity ; Cholinesterase Reactivators/Cholinesterase Reactivators/Cholinesterase Reactivators/*administration & dosage

  • Source: Toxicology [Toxicology] 2020 Nov; Vol. 444, pp. 152578. Date of Electronic Publication: 2020 Sep 06.Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3185

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A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.

  • Authors : Kranawetvogl T; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany.; Walther-Straub-Institut, Ludwig-Maximilians-Universität, Munich, Germany.

Subjects: Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/Chromatography, High Pressure Liquid/*methods ; Obidoxime Chloride/Obidoxime Chloride/Obidoxime Chloride/*analysis ; Oximes/Oximes/Oximes/*analysis

  • Source: Drug testing and analysis [Drug Test Anal] 2020 Jul; Vol. 12 (7), pp. 938-947. Date of Electronic Publication: 2020 Apr 23.Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.

  • Authors : Calas AG; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, F-91220 Brétigny-sur-Orge, France.; COGNition and ACtion Group, UMR 8257, CNRS-MD-UPV, Centre Universitaire des Saints-Pères, F-75006 Paris, France.

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*metabolism ; Cholinesterase Inhibitors/Cholinesterase Inhibitors/Cholinesterase Inhibitors/*pharmacology ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*pharmacology

  • Source: Biomolecules [Biomolecules] 2020 Jun 04; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 04.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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Academic Journal

Pralidoxime administered during cardiopulmonary resuscitation facilitates successful resuscitation in a pig model of cardiac arrest.

  • Authors : Jung YH; Department of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea.; Department of Emergency Medicine, Chonnam National University Medical School, Gwangju, Korea.

Subjects: Disease Models, Animal*; Antidotes/Antidotes/Antidotes/*therapeutic use ; Cardiopulmonary Resuscitation/Cardiopulmonary Resuscitation/Cardiopulmonary Resuscitation/*methods

  • Source: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Feb; Vol. 47 (2), pp. 236-246. Date of Electronic Publication: 2019 Nov 17.Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study.

  • Authors : da Silva JAV; Chemical, Biological, Radiological and Nuclear Defense Institute, Avenida das Americas, 28705, Guaratiba, 23020-470 Rio de Janeiro/RJ, Brazil.; Pereira AF

Subjects: Acetylcholinesterase/Acetylcholinesterase/Acetylcholinesterase/*drug effects ; Organothiophosphorus Compounds/Organothiophosphorus Compounds/Organothiophosphorus Compounds/*pharmacology ; Pralidoxime Compounds/Pralidoxime Compounds/Pralidoxime Compounds/*pharmacology

  • Source: Biomolecules [Biomolecules] 2020 Jan 27; Vol. 10 (2). Date of Electronic Publication: 2020 Jan 27.Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X

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  • 1-10 of  1,392 results for ""Pralidoxime Compounds""