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BACE2 beyond β-processing of APP, its neuroprotective role in cerebrovascular endothelium.

  • Authors : Sáez-Valero J; Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Alicante, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Subjects: Amyloid Precursor Protein Secretases* ; Alzheimer Disease*; Humans

  • Source: Journal of neurochemistry [J Neurochem] 2023 Sep; Vol. 166 (6), pp. 887-890. Date of Electronic Publication: 2023 Aug 16.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

BACE1 SUMOylation deregulates phosphorylation and ubiquitination in Alzheimer's disease pathology.

  • Authors : Zhao Y; Institutes of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, China.; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, Wuhan, China.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/metabolism; Animals

  • Source: Journal of neurochemistry [J Neurochem] 2023 Jul; Vol. 166 (2), pp. 318-327. Date of Electronic Publication: 2023 Jun 07.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent manner.

  • Authors : Lee WJ; College of Sang-Huh Life Sciences, Konkuk University, Seoul, Korea.; Ham SA

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*drug effects ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*drug effects

  • Source: Journal of neurochemistry [J Neurochem] 2019 Nov; Vol. 151 (3), pp. 370-385. Date of Electronic Publication: 2019 Jun 18.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

Reduced Aβ secretion by human neurons under conditions of strongly increased BACE activity.

  • Authors : Scholz D; Chair for in vitro Toxicology and Biomedicine, University of Konstanz, Konstanz, Germany.; Chernyshova Y

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Journal of neurochemistry [J Neurochem] 2018 Oct; Vol. 147 (2), pp. 256-274. Date of Electronic Publication: 2018 Sep 26.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

Serum beta-secretase 1 (BACE1) activity increases in patients with mild cognitive impairment.

  • Authors : Zuliani G; Department of Translational Medicine and for Romagna, University of Ferrara, Ferrara, Italy.; Trentini A

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*blood ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*blood ; Cognitive Dysfunction/Cognitive Dysfunction/Cognitive Dysfunction/*blood

  • Source: Journal of neurochemistry [J Neurochem] 2021 Nov; Vol. 159 (3), pp. 629-637. Date of Electronic Publication: 2021 Oct 03.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Report

An exercise path to preventing Alzheimer's disease: An Editorial Highlight on 'Exercise and BDNF reduce Ab production by enhancing α-secretase processing of APP'.

  • Authors : Coulson EJ; School of Biomedical Sciences, Queensland Brain Institute, The University of Queensland, Brisbane, Australia.; Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, Australia.

Subjects: Alzheimer Disease* ; Amyloid Precursor Protein Secretases*; Amyloid beta-Peptides

  • Source: Journal of neurochemistry [J Neurochem] 2017 Jul; Vol. 142 (2), pp. 191-193. Date of Electronic Publication: 2017 May 18.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.

  • Authors : Li KY; Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology, Chongqing, China.; Department of Neurology, the Second People's Hospital of Chengdu, Chengdu, China.

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Journal of neurochemistry [J Neurochem] 2021 May; Vol. 157 (4), pp. 1351-1365. Date of Electronic Publication: 2020 Sep 30.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

Neurological dysfunctions associated with altered BACE1-dependent Neuregulin-1 signaling.

  • Authors : Hu X; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.; Fan Q

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism ; Nervous System Diseases/Nervous System Diseases/Nervous System Diseases/*metabolism

  • Source: Journal of neurochemistry [J Neurochem] 2016 Jan; Vol. 136 (2), pp. 234-49. Date of Electronic Publication: 2015 Nov 13.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Academic Journal

Akt1 phosphorylates Nicastrin to regulate its protein stability and activity.

  • Authors : Jo EH; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.; Ahn JS

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Membrane Glycoproteins/Membrane Glycoproteins/Membrane Glycoproteins/*metabolism ; Proto-Oncogene Proteins c-akt/Proto-Oncogene Proteins c-akt/Proto-Oncogene Proteins c-akt/*physiology

  • Source: Journal of neurochemistry [J Neurochem] 2015 Sep; Vol. 134 (5), pp. 799-810. Date of Electronic Publication: 2015 Jul 16.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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Editorial & Opinion

Fishing for function--distinct roles of Bace1 and Bace2 in Zebrafish development.

  • Authors : Walter J; Department of Neurology, University of Bonn, Bonn, Germany.

Subjects: Disease Models, Animal*; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*physiology ; Zebrafish/Zebrafish/Zebrafish/*embryology

  • Source: Journal of neurochemistry [J Neurochem] 2013 Nov; Vol. 127 (4), pp. 435-7. Date of Electronic Publication: 2013 Mar 25.Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R

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  • 1-10 of  204 results for ""Amyloid Precursor Protein Secretases""