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Academic Journal

No effect on QT intervals of mipomersen, a 2'-O-methoxyethyl modified antisense oligonucleotide targeting ApoB-100 mRNA, in a phase I dose escalation placebo-controlled study, and confirmed by a thorough QT (tQT) study, in healthy subjects.

  • Authors : Yu RZ; Isis Pharmaceuticals, Inc., 2855 Gazelle Court, Carlsbad, CA, 92010, USA. .; Gunawan R

Subjects: Electrocardiography/Electrocardiography/Electrocardiography/*drug effects ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*pharmacology ; Oligonucleotides/Oligonucleotides/Oligonucleotides/*pharmacology

  • Source: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2016 Mar; Vol. 72 (3), pp. 267-75. Date of Electronic Publication: 2015 Dec 09.Publisher: Springer Country of Publication: Germany NLM ID: 1256165 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Antisense Oligonucleotides Targeting Lipoprotein(a).

  • Authors : Langsted A; Department of Clinical Biochemistry, Herlev Gentofte Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Denmark. .; Copenhagen General Population Study, Herlev and Gentofte Hospital Copenhagen University Hospital, Herlev, Denmark. .

Subjects: Apoprotein(a)/Apoprotein(a)/Apoprotein(a)/*antagonists & inhibitors ; Hyperlipoproteinemias/Hyperlipoproteinemias/Hyperlipoproteinemias/*drug therapy ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*pharmacology

  • Source: Current atherosclerosis reports [Curr Atheroscler Rep] 2019 May 20; Vol. 21 (8), pp. 30. Date of Electronic Publication: 2019 May 20.Publisher: Springer Country of Publication: United States NLM ID: 100897685 Publication Model: Electronic Cited Medium:

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Academic Journal

Designing antisense to inhibit the renin-angiotensin system.

  • Authors : Mohuczy D; Department of Physiology, College of Medicine, University of Florida, 32610-2452, USA.; Phillips MI

Subjects: Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*chemical synthesis ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*pharmacology ; Renin-Angiotensin System/Renin-Angiotensin System/Renin-Angiotensin System/*drug effects

  • Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2000 Sep; Vol. 212 (1-2), pp. 145-53.Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print Cited Medium: Print

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Academic Journal

Selective transvascular delivery of oligodeoxynucleotides to experimental brain tumors.

  • Authors : Koga H; Department of Neurosurgery, Neurological Institute, Kyushu University Faculty of Medicine, Fukuoka, Japan.; Inamura T

Subjects: Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*drug therapy ; Glioma/Glioma/Glioma/*drug therapy ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*pharmacokinetics

  • Source: Journal of neuro-oncology [J Neurooncol] 1999 Jun; Vol. 43 (2), pp. 143-51.Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print Cited Medium: Print

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Academic Journal

trans-(NH3)(2)Pt(II)-modified deoxyoligonucleotides as potential antisense agents: cross-linking reactions between two 12-mers.

  • Authors : Janik MB; Fachbereich Chemie, Universität Dortmund Otto-Hahn-Strasse 6, D-44221 Dortmund, Germany.; Lippert B

Subjects: Cisplatin/Cisplatin/Cisplatin/*chemistry ; Cross-Linking Reagents/Cross-Linking Reagents/Cross-Linking Reagents/*chemistry ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*chemistry

  • Source: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 1999 Oct; Vol. 4 (5), pp. 645-53.Publisher: Springer Country of Publication: Germany NLM ID: 9616326 Publication Model: Print Cited Medium: Print ISSN:

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Report

Growth inhibition of human liver cancer cells by alpha-fetoprotein antisense strategy.

Subjects: Liver/Liver/Liver/*cytology ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*pharmacology ; alpha-Fetoproteins/alpha-Fetoproteins/alpha-Fetoproteins/*antagonists & inhibitors

  • Source: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 1999 Mar; Vol. 35 (3), pp. 118-9.Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print Cited Medium: Print ISSN:

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Academic Journal

Antisense oligonucleotides: treating neurodegeneration at the level of RNA.

  • Authors : DeVos SL; Department of Neurology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA. ; Miller TM

Subjects: Neurodegenerative Diseases/Neurodegenerative Diseases/Neurodegenerative Diseases/*metabolism ; Neurodegenerative Diseases/Neurodegenerative Diseases/Neurodegenerative Diseases/*therapy ; Neuroprotective Agents/Neuroprotective Agents/Neuroprotective Agents/*therapeutic use

  • Source: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2013 Jul; Vol. 10 (3), pp. 486-97.Publisher: Springer Country of Publication: United States NLM ID: 101290381 Publication Model: Print Cited Medium:

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Academic Journal

Regulation of connexin43 gap junction protein triggers vascular recovery and healing in human ocular persistent epithelial defect wounds.

  • Authors : Ormonde S; Department of Ophthalmology, Faculty of Medical and Health Sciences, New Zealand National Eye Centre, University of Auckland, Private Bag 92019, Auckland, New Zealand.; Chou CY

Subjects: Connexin 43/Connexin 43/Connexin 43/*metabolism ; Connexins/Connexins/Connexins/*metabolism ; Corneal Diseases/Corneal Diseases/Corneal Diseases/*drug therapy

  • Source: The Journal of membrane biology [J Membr Biol] 2012 Jul; Vol. 245 (7), pp. 381-8. Date of Electronic Publication: 2012 Jul 15.Publisher: Springer Country of Publication: United States NLM ID: 0211301 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Effects of antisense oligonucleotides to mRNA for the early gene zif268 on the mechanisms of synapse-specific plasticity.

  • Authors : Nikitin VP; P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow. ; Kozyrev SA

Subjects: Early Growth Response Protein 1/Early Growth Response Protein 1/Early Growth Response Protein 1/*antagonists & inhibitors ; Neuronal Plasticity/Neuronal Plasticity/Neuronal Plasticity/*drug effects ; Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/Oligodeoxyribonucleotides, Antisense/*pharmacology

  • Source: Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2007 Jul; Vol. 37 (6), pp. 607-12.Publisher: Springer Country of Publication: United States NLM ID: 0330471 Publication Model: Print Cited Medium: Print

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Academic Journal

Identification and characterization of syntaxin 1 antisense variants in Limulus polyphemus.

  • Authors : Cao Z; Department of Biomedical Sciences, Meharry Medical College, Nashville, Tennessee 37208, USA.; Wang Y

Subjects: Syntaxin 1*/Syntaxin 1*/Syntaxin 1*/genetics ; Syntaxin 1*/Syntaxin 1*/Syntaxin 1*/metabolism; Horseshoe Crabs/Horseshoe Crabs/Horseshoe Crabs/*metabolism

  • Source: Cellular and molecular neurobiology [Cell Mol Neurobiol] 2006 Feb; Vol. 26 (1), pp. 53-66.Publisher: Springer Country of Publication: Netherlands NLM ID: 8200709 Publication Model: Print Cited Medium: Print

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  • 1-10 of  28 results for ""Oligodeoxyribonucleotides, Antisense""