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Prenatal treatment with preimplantation factor improves early postnatal neurogenesis and cognitive impairments in a mouse model of Down syndrome.

• Authors : Moreau M; Université Paris Cité, BFA, UMR 8251, CNRS, Paris, F-75013, France.; Dard R

Subjects: Down Syndrome*/Down Syndrome*/Down Syndrome*/drug therapy ; Down Syndrome*/Down Syndrome*/Down Syndrome*/pathology ; Down Syndrome*/Down Syndrome*/Down Syndrome*/metabolism

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2024 May 13; Vol. 81 (1), pp. 215. Date of Electronic Publication: 2024 May 13.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium:

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DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesis.

• Authors : Laham AJ; College of Medicine, University of Sharjah, Sharjah, UAE.; Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE.

Subjects: Carcinogenesis/Carcinogenesis/Carcinogenesis/*metabolism ; Down Syndrome/Down Syndrome/Down Syndrome/*metabolism ; Neoplasms/Neoplasms/Neoplasms/*metabolism

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2021 Jan; Vol. 78 (2), pp. 603-619. Date of Electronic Publication: 2020 Sep 01.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium:

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Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2.

• Authors : Morrugares R; Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Avda. Menéndez Pidal s/n. 14004, Córdoba, Spain.; Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain.

Subjects: Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/*metabolism ; Protein-Tyrosine Kinases/Protein-Tyrosine Kinases/Protein-Tyrosine Kinases/*metabolism ; Receptor, Notch1/Receptor, Notch1/Receptor, Notch1/*metabolism

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2020 Jul; Vol. 77 (13), pp. 2621-2639. Date of Electronic Publication: 2019 Oct 11.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium:

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How to design potent and selective DYRK1B inhibitors? Molecular modeling study.

• Authors : Szamborska-Gbur A; Selvita S.A., Bobrzyńskiego 14, 30-348, Kraków, Poland.; Rutkowska E

Subjects: Drug Design* ; Molecular Docking Simulation* ; Molecular Dynamics Simulation*

• Source: Journal of molecular modeling [J Mol Model] 2019 Jan 23; Vol. 25 (2), pp. 41. Date of Electronic Publication: 2019 Jan 23.Publisher: Springer Country of Publication: Germany NLM ID: 9806569 Publication Model: Electronic Cited Medium: Internet

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DYRK1B regulates Hedgehog-induced microtubule acetylation.

• Authors : Singh R; Institute of Molecular Biology and Tumor Research (IMT), Center for Tumor- and Immune Biology (ZTI), Philipps University, Hans-Meerwein-Str. 3, 35043, Marburg, Germany.; Holz PS

Subjects: Signal Transduction*; Hedgehog Proteins/Hedgehog Proteins/Hedgehog Proteins/*metabolism ; Microtubules/Microtubules/Microtubules/*metabolism

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Jan; Vol. 76 (1), pp. 193-207. Date of Electronic Publication: 2018 Oct 13.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium:

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Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.

• Authors : Ashford AL; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. .; Dunkley TP

Subjects: Metabolic Syndrome/Metabolic Syndrome/Metabolic Syndrome/*genetics ; Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase 3/Mitogen-Activated Protein Kinase 3/*metabolism ; Neoplasms/Neoplasms/Neoplasms/*genetics

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2016 Feb; Vol. 73 (4), pp. 883-900. Date of Electronic Publication: 2015 Sep 07.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium:

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Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A.

• Authors : Sarno S; Department of Biological Chemistry, University of Padua, V.le G. Colombo 3, 35131 Padua, Italy.; Mazzorana M

Subjects: Casein Kinase II/Casein Kinase II/Casein Kinase II/*antagonists & inhibitors ; Coumarins/Coumarins/Coumarins/*chemistry ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*chemistry

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2012 Feb; Vol. 69 (3), pp. 449-60. Date of Electronic Publication: 2011 Jul 01.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium:

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The kinase DYRKIA regulates pre-mRNA splicing in spermatogonia and proliferation of spermatogonia and Sertoli cells by phosphorylating a spliceosomal component, SAP155, in postnatal murine testes.

• Authors : Eto K; Department of Biological Sciences, Graduate School of Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan. ; Sonoda Y

Subjects: Cell Proliferation* ; RNA Splicing*/RNA Splicing*/RNA Splicing*/drug effects; Phosphoproteins/Phosphoproteins/Phosphoproteins/*metabolism

• Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2011 Sep; Vol. 355 (1-2), pp. 217-22. Date of Electronic Publication: 2011 May 08.Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium:

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Function and regulation of Dyrk1A: towards understanding Down syndrome.

• Authors : Park J; Department of Biology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.; Song WJ

Subjects: Gene Expression Regulation*; Down Syndrome/Down Syndrome/Down Syndrome/*genetics ; Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/Protein Serine-Threonine Kinases/*physiology

• Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2009 Oct; Vol. 66 (20), pp. 3235-40. Date of Electronic Publication: 2009 Aug 14.Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium:

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Deciphering Drug Targets for Alzheimer’s Disease

• Authors : Dileep Kumar; Vaishali M. Patil; Dee Wu

Subjects: Alzheimer's disease--Treatment; Drug targetingMEDICAL / Research; SCIENCE / Biotechnology; SCIENCE / Life Sciences / General

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