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Publisher : royal society of chemistry
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Academic Journal

Targeted protein degradation directly engaging lysosomes or proteasomes.

Subjects: PROTEOLYSIS; PROTEASOMES; MEMBRANE proteins

  • Source: Chemical Society Reviews; 4/7/2024, Vol. 53 Issue 7, p3253-3272, 20p

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Academic Journal

Native mass spectrometry of complexes formed by molecular glues reveals stoichiometric rearrangement of E3 ligases.

Subjects: LIGASES; UBIQUITIN ligases; MASS spectrometry

  • Source: Analyst; 6/7/2024, Vol. 149 Issue 11, p3178-3185, 8p

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Academic Journal

Total chemical synthesis of sumoylated histone H4 reveals negative biochemical crosstalk with histone ubiquitylation.

Subjects: CHEMICAL synthesis; BIOCHEMICAL substrates; HISTONES

  • Source: Chemical Communications; 4/7/2023, Vol. 59 Issue 27, p4063-4066, 4p

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Academic Journal

An activity-based probe developed by a sequential dehydroalanine formation strategy targets HECT E3 ubiquitin ligases.

Subjects: UBIQUITIN ligases; UBIQUITINATION

  • Source: Chemical Communications; 6/21/2019, Vol. 55 Issue 49, p7109-7112, 4p

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Academic Journal

Methods to characterize and discover molecular degraders in cells.

Subjects: UBIQUITINATION; SMALL molecules; POST-translational modification

  • Source: Chemical Society Reviews; 8/21/2022, Vol. 51 Issue 16, p7115-7137, 23p

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Academic Journal

Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders.

Subjects: UBIQUITIN ligases; THALIDOMIDE; PROTEINS

  • Source: Chemical Society Reviews; 8/7/2022, Vol. 51 Issue 15, p6234-6250, 17p

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Academic Journal

Chasing molecular glue degraders: screening approaches.

Subjects: PROTEIN-protein interactions; UBIQUITIN ligases; PROTEOLYSIS

  • Source: Chemical Society Reviews; 7/7/2022, Vol. 51 Issue 13, p5498-5517, 20p

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Academic Journal

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders.

Subjects: SMALL molecules; UBIQUITINATION; UBIQUITIN ligases

  • Source: Chemical Society Reviews; 10/7/2022, Vol. 51 Issue 19, p8216-8257, 42p

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Academic Journal

PROTACs: past, present and future.

Subjects: UBIQUITIN ligases; SMALL molecules; PROTEOLYSIS

  • Source: Chemical Society Reviews; 6/21/2022, Vol. 51 Issue 12, p5214-5236, 23p

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Academic Journal

The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation.

Subjects: UBIQUITINATION; PROTEOLYSIS; UBIQUITIN ligases

  • Source: Chemical Society Reviews; 7/21/2022, Vol. 51 Issue 14, p6210-6221, 12p

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  • 1-10 of  107 results for ""UBIQUITIN ligases""