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Probing the binding and antiparasitic efficacy of azobenzene G-quadruplex ligands to investigate G4 ligand design.

• Authors : Ramos-Soriano J; School of Chemistry, Cantock's Close, University of Bristol, BS8 1TS, UK.; Holbrow-Wilshaw M

Subjects: G-Quadruplexes*/G-Quadruplexes*/G-Quadruplexes*/drug effects ; Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/Trypanosoma brucei brucei*/drug effects ; Azo Compounds*/Azo Compounds*/Azo Compounds*/chemistry

• Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Oct 08; Vol. 60 (81), pp. 11520-11523. Date of Electronic Publication: 2024 Oct 08.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited

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Discovery of N-(4-sulfamoylphenyl)thioureas as Trypanosoma brucei leucyl-tRNA synthetase inhibitors.

• Authors : Zhang F; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.; Du J

Subjects: Leucine-tRNA Ligase/Leucine-tRNA Ligase/Leucine-tRNA Ligase/*antagonists & inhibitors ; Thiourea/Thiourea/Thiourea/*analogs & derivatives ; Thiourea/Thiourea/Thiourea/*pharmacology

• Source: Organic & biomolecular chemistry [Org Biomol Chem] 2013 Aug 28; Vol. 11 (32), pp. 5310-24.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited

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Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei.

• Authors : Yang PY; Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.; Wang M

Subjects: Antiparasitic Agents/Antiparasitic Agents/Antiparasitic Agents/*pharmacology ; Cysteine Proteinase Inhibitors/Cysteine Proteinase Inhibitors/Cysteine Proteinase Inhibitors/*pharmacology ; Dipeptides/Dipeptides/Dipeptides/*pharmacology

• Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2012 Jan 21; Vol. 48 (6), pp. 835-7. Date of Electronic Publication: 2011 Nov 28.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Print-Electronic

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Microfluidics-based single cell analysis reveals drug-dependent motility changes in trypanosomes.

• Authors : Hochstetter A; Department of Chemistry, University of Basel, 4056 Basel, Switzerland. .; Stellamanns E

Subjects: Lab-On-A-Chip Devices*; Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/Drug Evaluation, Preclinical/*instrumentation ; Single-Cell Analysis/Single-Cell Analysis/Single-Cell Analysis/*instrumentation

• Source: Lab on a chip [Lab Chip] 2015 Apr 21; Vol. 15 (8), pp. 1961-8.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Print Cited

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Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones.

• Authors : Doherty W; Centre for Synthesis and Chemical Biology, School of Chemistry and Chemical Biology, University College Dublin, Dublin 4, Ireland. .; James J

Subjects: Dipeptides/Dipeptides/Dipeptides/*chemistry ; Sulfones/Sulfones/Sulfones/*chemistry ; Sulfones/Sulfones/Sulfones/*pharmacology

• Source: Organic & biomolecular chemistry [Org Biomol Chem] 2014 Oct 14; Vol. 12 (38), pp. 7561-71.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited

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Probing the substrate specificity of Trypanosoma brucei GlcNAc-PI de-N-acetylase with synthetic substrate analogues.

• Authors : Capes AS; Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. .; Crossman A

Subjects: Amidohydrolases/Amidohydrolases/Amidohydrolases/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Glucosamine/Glucosamine/Glucosamine/*analogs & derivatives

• Source: Organic & biomolecular chemistry [Org Biomol Chem] 2014 Mar 28; Vol. 12 (12), pp. 1919-34. Date of Electronic Publication: 2014 Feb 12.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic

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New organoruthenium complexes with bioactive thiosemicarbazones as co-ligands: potential anti-trypanosomal agents.

• Authors : Demoro B; Cátedra de Química Inorgánica, Departamento Estrella Campos, Facultad de Química, Universidad de la República (UdelaR), Gral. Flores 2124, 11800, Montevideo, Uruguay.; Sarniguet C

Subjects: Organoselenium Compounds/Organoselenium Compounds/Organoselenium Compounds/*chemistry ; Organoselenium Compounds/Organoselenium Compounds/Organoselenium Compounds/*pharmacology ; Trypanocidal Agents/Trypanocidal Agents/Trypanocidal Agents/*chemistry

• Source: Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2012 Feb 07; Vol. 41 (5), pp. 1534-43. Date of Electronic Publication: 2011 Dec 02.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101176026 Publication Model: Print-Electronic

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Synthesis of bicyclic 1,4-thiazepines as novel anti-Trypanosoma brucei brucei agents.

• Authors : Vairoletti, Franco; Medeiros, Andrea; Fontán, Pablo

• Source: MedChemComm; Aug2019, Vol. 10 Issue 8, p1481-1487, 7p

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Synthesis of the 5/5-spiroindimicin alkaloids: development of a general synthetic approach and biological investigations.

• Authors : Banerjee A; Department of Biochemistry, UT Southwestern Medical Center, Dallas, Texas 75390, USA. .; Brisco TA

Subjects: Spiro Compounds*/Spiro Compounds*/Spiro Compounds*/chemistry ; Spiro Compounds*/Spiro Compounds*/Spiro Compounds*/chemical synthesis ; Alkaloids*/Alkaloids*/Alkaloids*/chemical synthesis

• Source: Organic & biomolecular chemistry [Org Biomol Chem] 2024 Dec 11; Vol. 22 (48), pp. 9413-9425. Date of Electronic Publication: 2024 Dec 11.Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited

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A targeted delivery strategy for the development of potent trypanocides.

• Authors : Gordhan, Heeren M.¹; Milanes, Jillian E.²; Qiu, Yijian²

Subjects: *DRUG delivery systems; *TRYPANOSOMA brucei; *AFRICAN trypanosomiasis

• Source: Chemical Communications. 8/11/2017, Vol. 53 Issue 62, p8735-8738. 4p.

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