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Academic Journal

The intrinsic substrate specificity of the human tyrosine kinome.

  • Authors : Yaron-Barir TM; Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Subjects: Phosphotyrosine*/Phosphotyrosine*/Phosphotyrosine*/metabolism ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/drug effects ; Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/Protein-Tyrosine Kinases*/metabolism

  • Source: Nature [Nature] 2024 May; Vol. 629 (8014), pp. 1174-1181. Date of Electronic Publication: 2024 May 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Targeted protein degradation via intramolecular bivalent glues.

  • Authors : Hsia O; Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, UK.; Hinterndorfer M

Subjects: Drug Design* ; Proteolysis* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: Nature [Nature] 2024 Mar; Vol. 627 (8002), pp. 204-211. Date of Electronic Publication: 2024 Feb 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Structural basis for broad substrate specificity of UDP-glucose 4-epimerase in the human milk oligosaccharide catabolic pathway of Bifidobacterium longum.

  • Authors : Nam YW; Department of Biotechnology, The University of Tokyo, Tokyo, 113-8657, Japan.; Department of Biomedical and Pharmaceutical Sciences & Structural Biology Research Center, Chapman University School of Pharmacy, Irvine, CA 92618, USA.

Subjects: Bifidobacterium longum/Bifidobacterium longum/Bifidobacterium longum/*metabolism ; Catalytic Domain/Catalytic Domain/Catalytic Domain/*physiology ; Milk, Human/Milk, Human/Milk, Human/*metabolism

  • Source: Scientific reports [Sci Rep] 2019 Jul 31; Vol. 9 (1), pp. 11081. Date of Electronic Publication: 2019 Jul 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

  • Authors : Poreba M; Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland.; NCI-designated Cancer Center, Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

Subjects: Substrate Specificity*; Cysteine Proteases/Cysteine Proteases/Cysteine Proteases/*metabolism ; Fluorometry/Fluorometry/Fluorometry/*methods

  • Source: Scientific reports [Sci Rep] 2017 Feb 23; Vol. 7, pp. 43135. Date of Electronic Publication: 2017 Feb 23.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

DNA surface exploration and operator bypassing during target search.

  • Authors : Marklund E; Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; van Oosten B

Subjects: Nucleic Acid Conformation* ; Substrate Specificity*/Substrate Specificity*/Substrate Specificity*/genetics; DNA/DNA/DNA/*chemistry

  • Source: Nature [Nature] 2020 Jul; Vol. 583 (7818), pp. 858-861. Date of Electronic Publication: 2020 Jun 24.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Enzyme modification using mutation site prediction method for enhancing the regioselectivity of substrate reaction sites.

  • Authors : Ikebe J; Artificial Intelligence Research Center, National Institute of Advanced Industrial Science and Technology (AIST), 2-4-7 Aomi, Koto-ku, Tokyo, 135-0064, Japan.; Suzuki M

Subjects: Enzymes/Enzymes/Enzymes/*genetics ; Protein Engineering/Protein Engineering/Protein Engineering/*methods ; Substrate Specificity/Substrate Specificity/Substrate Specificity/*genetics

  • Source: Scientific reports [Sci Rep] 2021 Oct 04; Vol. 11 (1), pp. 19004. Date of Electronic Publication: 2021 Oct 04.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference.

  • Authors : Dann GP; Department of Chemistry, Princeton University, Frick Laboratory, Princeton, New Jersey 08544, USA.; Liszczak GP

Subjects: Chromatin Assembly and Disassembly* ; Substrate Specificity*; Adenosine Triphosphatases/Adenosine Triphosphatases/Adenosine Triphosphatases/*metabolism

  • Source: Nature [Nature] 2017 Aug 31; Vol. 548 (7669), pp. 607-611. Date of Electronic Publication: 2017 Aug 02.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Phenotype, specificity and avidity of antitumour CD8 + T cells in melanoma.

  • Authors : Oliveira G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.

Subjects: CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*immunology ; Melanoma/Melanoma/Melanoma/*immunology ; Substrate Specificity/Substrate Specificity/Substrate Specificity/*immunology

  • Source: Nature [Nature] 2021 Aug; Vol. 596 (7870), pp. 119-125. Date of Electronic Publication: 2021 Jul 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

DNA-dependent formation of transcription factor pairs alters their binding specificity.

  • Authors : Jolma A; Department of Biosciences and Nutrition, Karolinska Institutet, SE 141 83, Sweden.; Yin Y

Subjects: Substrate Specificity*/Substrate Specificity*/Substrate Specificity*/genetics; DNA/DNA/DNA/*genetics ; DNA/DNA/DNA/*metabolism

  • Source: Nature [Nature] 2015 Nov 19; Vol. 527 (7578), pp. 384-8. Date of Electronic Publication: 2015 Nov 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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Academic Journal

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors.

  • Authors : Grünewald J; Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, MA, USA.; Center for Cancer Research, Massachusetts General Hospital, Charlestown, MA, USA.

Subjects: Gene Editing* ; RNA Editing*; CRISPR-Cas Systems/CRISPR-Cas Systems/CRISPR-Cas Systems/*genetics

  • Source: Nature [Nature] 2019 May; Vol. 569 (7756), pp. 433-437. Date of Electronic Publication: 2019 Apr 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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  • 1-10 of  4,522 results for ""Substrate Specificity""