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AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

• Authors : Lee S; Department of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.; Karki R

Subjects: Apoptosis/Apoptosis/Apoptosis/*immunology ; DNA-Binding Proteins/DNA-Binding Proteins/DNA-Binding Proteins/*metabolism ; Necroptosis/Necroptosis/Necroptosis/*immunology Francisella tularensis subsp. novicida

• Source: Nature [Nature] 2021 Sep; Vol. 597 (7876), pp. 415-419. Date of Electronic Publication: 2021 Sep 01.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited

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The PRY/SPRY domain of pyrin/TRIM20 interacts with β 2 -microglobulin to promote inflammasome formation.

• Authors : Samukawa S; Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.; Yoshimi R

Subjects: Inflammasomes/Inflammasomes/Inflammasomes/*metabolism ; Pyrin/Pyrin/Pyrin/*metabolism ; beta 2-Microglobulin/beta 2-Microglobulin/beta 2-Microglobulin/*metabolism

• Source: Scientific reports [Sci Rep] 2021 Dec 08; Vol. 11 (1), pp. 23613. Date of Electronic Publication: 2021 Dec 08.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis.

• Authors : Park, Yong Hwan; Remmers, Elaine F.; Lee, Wonyong

• Source: Nature Immunology. August, 2020, Vol. 21 Issue 8, p857, 11 p.

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Pyrin variants can burn out the plague

• Authors : Bordon, Yvonne

• Source: Nature Reviews Immunology. August, 2020, Vol. 20 Issue 8, p462, 2 p.

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Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS.

• Authors : Park, Yong Hwan; Wood, Geryl; Kastner, Daniel L.

• Source: Nature Immunology. August 1, 2016, p914, 10 p.

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CATERPILLERs, pyrin and hereditary immunological disorders

• Authors : Ting, Jenny P.-Y.; Kastner, Daniel L.; Hoffman, Hal M.

• Source: Nature Reviews Immunology. March, 2006, Vol. 6 Issue 3, p183, 13 p.

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Innate immune sensing of bacterial modifications of Rho GTPases by the pyrin inflammasome.

• Authors : Xu, Hao; Yang, Jieling; Gao, Wenqing

• Source: Nature. September 11, 2014, Vol. 513 Issue 7517, p237, 17 p.

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The CLRX.1/NOD24 (NLRP2P) pseudogene codes a functional negative regulator of NF-κB, pyrin-only protein 4.

• Authors : Porter, K.A.; Duffy, E.B.; Nyland, P.

• Source: Genes and Immunity. September 1, 2014, Vol. 15 Issue 6, p392, 12 p.

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The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses.

• Authors : Khare, Sonal; Ratsimandresy, Rojo A.; de Almeida, Lucia

• Source: Nature Immunology. April 1, 2014, Vol. 15 Issue 4, p343, 14 p.

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A dRAStic RHOAdblock of pyrin inflammasome activation.

• Authors : Dorfleutner, Andrea; Stehlik, Christian

• Source: Nature Immunology. August 1, 2016, p900, 3 p.

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