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Academic Journal

Non-clinical evaluation of pmIL12 gene therapy for approval of the phase I clinical study.

  • Authors : Markelc B; Institute of Oncology Ljubljana, 1000, Ljubljana, Slovenia.; Faculty of Health Sciences, University of Ljubljana, 1000, Ljubljana, Slovenia.

Subjects: Interleukin-12*/Interleukin-12*/Interleukin-12*/genetics ; Genetic Therapy*/Genetic Therapy*/Genetic Therapy*/methods; Animals

  • Source: Scientific reports [Sci Rep] 2024 Sep 27; Vol. 14 (1), pp. 22288. Date of Electronic Publication: 2024 Sep 27.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma.

  • Authors : Nilsson M; Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. .; Kozyrev SV

Subjects: Autoimmune Diseases*/Autoimmune Diseases*/Autoimmune Diseases*/veterinary ; Autoimmune Diseases*/Autoimmune Diseases*/Autoimmune Diseases*/immunology ; Lymphoma*/Lymphoma*/Lymphoma*/veterinary

  • Source: Scientific reports [Sci Rep] 2024 May 21; Vol. 14 (1), pp. 11624. Date of Electronic Publication: 2024 May 21.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

IL-12 sensing in neurons induces neuroprotective CNS tissue adaptation and attenuates neuroinflammation in mice.

  • Authors : Andreadou M; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.; Ingelfinger F

Subjects: Encephalomyelitis, Autoimmune, Experimental* ; Interleukin-12* ; Neuroprotection*

  • Source: Nature neuroscience [Nat Neurosci] 2023 Oct; Vol. 26 (10), pp. 1701-1712. Date of Electronic Publication: 2023 Sep 25.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic

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Academic Journal

Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm.

  • Authors : Yan H; John Cochran VA Medical Center, Saint Louis, Missouri, USA.; Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Saint Louis, Missouri, USA.

Subjects: Aortic Aneurysm, Abdominal/Aortic Aneurysm, Abdominal/Aortic Aneurysm, Abdominal/*prevention & control ; Inflammation Mediators/Inflammation Mediators/Inflammation Mediators/*metabolism ; Interleukin-12/Interleukin-12/Interleukin-12/*antagonists & inhibitors

  • Source: Scientific reports [Sci Rep] 2019 Jul 18; Vol. 9 (1), pp. 10447. Date of Electronic Publication: 2019 Jul 18.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12.

  • Authors : Hunter R; Cancer Biology Program, Laney Graduate School, Emory University, Atlanta, GA, USA.; Imbach KJ

Subjects: Interleukin-12*/Interleukin-12*/Interleukin-12*/genetics ; Interleukin-12*/Interleukin-12*/Interleukin-12*/metabolism ; Precursor Cell Lymphoblastic Leukemia-Lymphoma*/Precursor Cell Lymphoblastic Leukemia-Lymphoma*/Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism

  • Source: Scientific reports [Sci Rep] 2022 Jul 13; Vol. 12 (1), pp. 11870. Date of Electronic Publication: 2022 Jul 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Intratumoral DNA-based delivery of checkpoint-inhibiting antibodies and interleukin 12 triggers T cell infiltration and anti-tumor response.

  • Authors : Jacobs L; Laboratory for Therapeutic and Diagnostic Antibodies, KU Leuven - University of Leuven, Leuven, Belgium.; Yshii L

Subjects: CD8-Positive T-Lymphocytes* ; Immune Checkpoint Inhibitors*/Immune Checkpoint Inhibitors*/Immune Checkpoint Inhibitors*/administration & dosage ; Interleukin-12*/Interleukin-12*/Interleukin-12*/genetics

  • Source: Cancer gene therapy [Cancer Gene Ther] 2022 Jul; Vol. 29 (7), pp. 984-992. Date of Electronic Publication: 2021 Nov 09.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited

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Academic Journal

Antitumor effect of antibiotic resistance gene-free plasmids encoding interleukin-12 in canine melanoma model.

  • Authors : Lampreht Tratar U; Department of Experimental Oncology, Institute of Oncology Ljubljana, Zaloška 2, 1000, Ljubljana, Slovenia.; Kos S

Subjects: Drug Resistance, Microbial* ; Interleukin-12*/Interleukin-12*/Interleukin-12*/biosynthesis ; Interleukin-12*/Interleukin-12*/Interleukin-12*/genetics

  • Source: Cancer gene therapy [Cancer Gene Ther] 2018 Oct; Vol. 25 (9-10), pp. 260-273. Date of Electronic Publication: 2018 Mar 29.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited

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Academic Journal

Modulation of Interleukin-12 activity in the presence of heparin.

  • Authors : Jayanthi S; Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, USA.; Koppolu BP

Subjects: Heparin/Heparin/Heparin/*metabolism ; Immunologic Factors/Immunologic Factors/Immunologic Factors/*metabolism ; Interleukin-12/Interleukin-12/Interleukin-12/*metabolism

  • Source: Scientific reports [Sci Rep] 2017 Jul 13; Vol. 7 (1), pp. 5360. Date of Electronic Publication: 2017 Jul 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Mesenchymal stromal cells as carriers of IL-12 reduce primary and metastatic tumors of murine melanoma.

  • Authors : Kułach N; Center for Translational Research and Molecular Biology of Cancer, Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej Street 15, 44-102, Gliwice, Poland.; Pilny E

Subjects: Interleukin-12/Interleukin-12/Interleukin-12/*metabolism ; Melanoma/Melanoma/Melanoma/*therapy ; Mesenchymal Stem Cell Transplantation/Mesenchymal Stem Cell Transplantation/Mesenchymal Stem Cell Transplantation/*methods

  • Source: Scientific reports [Sci Rep] 2021 Sep 15; Vol. 11 (1), pp. 18335. Date of Electronic Publication: 2021 Sep 15.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Tumor perfusion evaluation using dynamic contrast-enhanced ultrasound after electrochemotherapy and IL-12 plasmid electrotransfer in murine melanoma.

  • Authors : Brloznik M; Clinic for Small Animals, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, Ljubljana, Slovenia.; Boc N

Subjects: Electrochemotherapy* ; Gene Transfer Techniques* ; Interleukin-12*/Interleukin-12*/Interleukin-12*/genetics

  • Source: Scientific reports [Sci Rep] 2021 Jun 29; Vol. 11 (1), pp. 13446. Date of Electronic Publication: 2021 Jun 29.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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  • 1-10 of  2,376 results for ""INTERLEUKIN-12""