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Academic Journal

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.

  • Authors : Nishi T; Research, Takeda Pharmaceutical Company Limited, Fujisawa, 251-8555, Japan. .; Takeda Pharmaceutical Company Limited, Cambridge, MA, 02139, USA. .

Subjects: Cholesterol 24-Hydroxylase/Cholesterol 24-Hydroxylase/Cholesterol 24-Hydroxylase/*antagonists & inhibitors ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology ; Piperidines/Piperidines/Piperidines/*pharmacology

  • Source: Scientific reports [Sci Rep] 2020 Oct 13; Vol. 10 (1), pp. 17081. Date of Electronic Publication: 2020 Oct 13.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

3-pyridyl inhibitors with novel activity against Trypanosoma cruzi reveal in vitro profiles can aid prediction of putative cytochrome P450 inhibition.

  • Authors : Sykes ML; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Nathan, Queensland, Australia. .; Avery VM

Subjects: Chagas Disease/Chagas Disease/Chagas Disease/*drug therapy ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology ; Sterol 14-Demethylase/Sterol 14-Demethylase/Sterol 14-Demethylase/*metabolism

  • Source: Scientific reports [Sci Rep] 2018 Mar 20; Vol. 8 (1), pp. 4901. Date of Electronic Publication: 2018 Mar 20.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Intravenous Formulation of HET0016 Decreased Human Glioblastoma Growth and Implicated Survival Benefit in Rat Xenograft Models.

  • Authors : Jain M; Tumor Angiogenesis Laboratory, Georgia Cancer Center, Augusta University, Augusta, GA, USA.; Gamage NH

Subjects: Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*administration & dosage ; Glioblastoma/Glioblastoma/Glioblastoma/*metabolism ; Glioblastoma/Glioblastoma/Glioblastoma/*pathology

  • Source: Scientific reports [Sci Rep] 2017 Jan 31; Vol. 7, pp. 41809. Date of Electronic Publication: 2017 Jan 31.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.

  • Authors : Xu L; Department of Physics and Astronomy, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX, 78249, USA. .; Chen LY

Subjects: Astemizole/Astemizole/Astemizole/*chemistry ; Butyrophenones/Butyrophenones/Butyrophenones/*chemistry ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology

  • Source: Scientific reports [Sci Rep] 2020 Dec 17; Vol. 10 (1), pp. 22267. Date of Electronic Publication: 2020 Dec 17.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Cytochrome P450 inhibition potential and initial genotoxic evaluation of 14-O-[(4,6-diaminopyrimidine-2-yl)thioacetyl] mutilin.

  • Authors : Fu Y; Key Laboratory of New Animal Drug Project, Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Qilihe District, No. 335, Lanzhou, 730050, People's Republic of China.; Henan University of Animal Husbandry and Economy, Zhengzhou, 450046, People's Republic of China.

Subjects: Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology ; Ketones/Ketones/Ketones/*pharmacology ; Polycyclic Compounds/Polycyclic Compounds/Polycyclic Compounds/*pharmacology

  • Source: Scientific reports [Sci Rep] 2020 Aug 10; Vol. 10 (1), pp. 13474. Date of Electronic Publication: 2020 Aug 10.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Predicting the need for a reduced drug dose, at first prescription.

  • Authors : Coulet A; Université de Lorraine, CNRS, Inria, LORIA, 54000, Nancy, France. .; Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA. .

Subjects: Drug Dosage Calculations*; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*administration & dosage ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*adverse effects

  • Source: Scientific reports [Sci Rep] 2018 Oct 22; Vol. 8 (1), pp. 15558. Date of Electronic Publication: 2018 Oct 22.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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Academic Journal

Pungent ginger components modulates human cytochrome P450 enzymes in vitro.

  • Authors : Li M; Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; University of the Chinese Academy of Sciences, Shanghai 200031, China.

Subjects: Cytochrome P-450 Enzyme Inhibitors* ; Zingiber officinale*; Catechols/Catechols/Catechols/*pharmacology

  • Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2013 Sep; Vol. 34 (9), pp. 1237-42. Date of Electronic Publication: 2013 Jun 17.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic

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Academic Journal

Substrate-dependent modulation of the catalytic activity of CYP3A by erlotinib.

  • Authors : Dong PP; Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.; Fang ZZ

Subjects: Cytochrome P-450 CYP3A Inhibitors* ; Cytochrome P-450 Enzyme Inhibitors*; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*pharmacology

  • Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2011 Mar; Vol. 32 (3), pp. 399-407.Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print Cited

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Academic Journal

Drug-virus interaction: effect of administration of recombinant adenoviruses on the pharmacokinetics of docetaxel in a rat model.

  • Authors : Wonganan P; Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712-1074, USA.; Zamboni WC

Subjects: Cytochrome P-450 Enzyme Inhibitors*; Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/Aryl Hydrocarbon Hydroxylases/*metabolism ; Genetic Vectors/Genetic Vectors/Genetic Vectors/*genetics

  • Source: Cancer gene therapy [Cancer Gene Ther] 2009 May; Vol. 16 (5), pp. 405-14. Date of Electronic Publication: 2008 Dec 26.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9432230 Publication Model: Print-Electronic Cited

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Academic Journal

Priming the body to receive the therapeutic agent to redefine treatment benefit/risk profile.

  • Authors : Germain M; NANOBIOTIX, 60 rue de Wattignies, Paris, 75012, France. .; Meyre ME

Subjects: Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*drug therapy ; Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/Cytochrome P-450 Enzyme Inhibitors/*pharmacology ; Docetaxel/Docetaxel/Docetaxel/*pharmacology

  • Source: Scientific reports [Sci Rep] 2018 Mar 19; Vol. 8 (1), pp. 4797. Date of Electronic Publication: 2018 Mar 19.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited

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  • 1-10 of  38 results for ""Cytochrome P-450 Enzyme Inhibitors""