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Academic Journal

SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase.

  • Authors : Zheng Q; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.; Woehl JL

Subjects: Fluorides/Fluorides/Fluorides/*chemistry ; Leukocyte Elastase/Leukocyte Elastase/Leukocyte Elastase/*antagonists & inhibitors ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Sep 17; Vol. 116 (38), pp. 18808-18814. Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model:

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Academic Journal

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

  • Authors : Chatre L; Institut Pasteur, Department of Genomes and Genetics, Unité de Génétique Moléculaire des Levures, 75724 Paris, France; CNRS UMR 3525, Team Stability of Nuclear and Mitochondrial DNA.

Subjects: Cockayne Syndrome/Cockayne Syndrome/Cockayne Syndrome/*drug therapy ; DNA Helicases/DNA Helicases/DNA Helicases/*metabolism ; DNA Repair Enzymes/DNA Repair Enzymes/DNA Repair Enzymes/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2015 Jun 02; Vol. 112 (22), pp. E2910-9. Date Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model:

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Academic Journal

Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.

  • Authors : Jiao GS; Departments of Chemistry, PanThera Biopharma LLC, 99-193 Aiea Heights Drive, Suite 136, Aiea, HI 96701, USA. ; Cregar L

Subjects: Furin/Furin/Furin/*antagonists & inhibitors ; Hexosamines/Hexosamines/Hexosamines/*chemistry ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*chemical synthesis

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2006 Dec 26; Vol. 103 (52), pp. 19707-12. DatePublisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model:

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Academic Journal

Inhibition of PCSK9: a powerful weapon for achieving ideal LDL cholesterol levels.

  • Authors : Steinberg D; Department of Medicine, University of California at San Diego, La Jolla, CA 92093-0682, USA.; Witztum JL

Subjects: Anticholesteremic Agents/Anticholesteremic Agents/Anticholesteremic Agents/*therapeutic use ; Cholesterol, LDL/Cholesterol, LDL/Cholesterol, LDL/*blood ; Serine Endopeptidases/Serine Endopeptidases/Serine Endopeptidases/*drug effects

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2009 Jun 16; Vol. 106 (24), pp. 9546-7. Date Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model:

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Academic Journal

The reactive site loop of the serpin SCCA1 is essential for cysteine proteinase inhibition.

  • Authors : Schick C; Department of Pediatrics, Harvard Medical School, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.; Brömme D

Subjects: Antigens, Neoplasm/Antigens, Neoplasm/Antigens, Neoplasm/*chemistry ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*chemistry ; Serpins/Serpins/Serpins/*chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1998 Nov 10; Vol. 95 (23), pp. 13465-70.Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited

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Academic Journal

Activity-based protein profiling: the serine hydrolases.

  • Authors : Liu Y; The Skaggs Institute for Chemical Biology, Department of Cell Biology, the Scripps Research Institute, La Jolla, CA 92037, USA.; Patricelli MP

Subjects: Biotin/Biotin/Biotin/*analogs & derivatives ; Gene Expression Profiling/Gene Expression Profiling/Gene Expression Profiling/*methods ; Organophosphorus Compounds/Organophosphorus Compounds/Organophosphorus Compounds/*pharmacology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1999 Dec 21; Vol. 96 (26), pp. 14694-9.Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited

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Academic Journal

Differential inhibition of the Fas- and granule-mediated cytolysis pathways by the orthopoxvirus cytokine response modifier A/SPI-2 and SPI-1 protein.

  • Authors : Macen JL; Department of Biochemistry, University of Alberta, Edmonton, Canada.; Garner RS

Subjects: Cytotoxicity, Immunologic*; Cytoplasmic Granules/Cytoplasmic Granules/Cytoplasmic Granules/*metabolism ; Orthopoxvirus/Orthopoxvirus/Orthopoxvirus/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1996 Aug 20; Vol. 93 (17), pp. 9108-13.Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited

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Academic Journal

Inhibitors of human heart chymase based on a peptide library.

  • Authors : Bastos M; Brandeis University Graduate Department of Biochemistry, Waltham, MA 02254, USA.; Maeji NJ

Subjects: Serine Endopeptidases*; Myocardium/Myocardium/Myocardium/*enzymology ; Peptides/Peptides/Peptides/*pharmacology

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1995 Jul 18; Vol. 92 (15), pp. 6738-42.Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited

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Academic Journal

Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.

  • Authors : Stapels DA; Medical Microbiology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands;

Subjects: Neutrophils/Neutrophils/Neutrophils/*metabolism ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*metabolism ; Staphylococcus aureus/Staphylococcus aureus/Staphylococcus aureus/*metabolism

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Sep 09; Vol. 111 (36), pp. 13187-92. DatePublisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model:

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Academic Journal

Complete reconstruction of an enzyme-inhibitor binding process by molecular dynamics simulations.

  • Authors : Buch I; Computational Biochemistry and Biophysics Laboratory, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, C/Doctor Aiguader 88, 08003 Barcelona, Spain.; Giorgino T

Subjects: Benzamidines/Benzamidines/Benzamidines/*chemistry ; Benzamidines/Benzamidines/Benzamidines/*metabolism ; Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/Serine Proteinase Inhibitors/*chemistry

  • Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2011 Jun 21; Vol. 108 (25), pp. 10184-9. Date Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model:

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  • 1-10 of  99 results for ""SERINE proteinase inhibitors""