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Academic Journal

BACE Inhibitor Clinical Trials for Alzheimer's Disease.

  • Authors : Watkins EA; Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Vassar R

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 101 (s1), pp. S41-S52.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

BACE1 Inhibitors for Alzheimer's Disease: Current Challenges and Future Perspectives.

  • Authors : Coimbra JRM; Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 101 (s1), pp. S53-S78.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

A Strategy for Allowing Earlier Diagnosis and Rigorous Evaluation of BACE1 Inhibitors in Preclinical Alzheimer's Disease.

  • Authors : Ohno M; Center for Dementia Research, Nathan Kline Institute, Orangeburg, NY, USA.

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/diagnosis ; Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/Amyloid Precursor Protein Secretases*/antagonists & inhibitors

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 99 (2), pp. 431-445.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer's Disease: Data from the PUMCH Dementia Cohort.

  • Authors : Dong L; Neurology Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.; Mao C

Subjects: ATP-Binding Cassette Transporters/ATP-Binding Cassette Transporters/ATP-Binding Cassette Transporters/*genetics ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*genetics

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 85 (4), pp. 1511-1518.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

Anti-Stroke Chinese Herbal Medicines Inhibit Abnormal Amyloid-β Protein Precursor Processing in Alzheimer's Disease.

  • Authors : Tan Y; Beijing University of Chinese Medicine, Beijing, China.; Zhang J

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2022; Vol. 85 (1), pp. 261-272.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

Increase of BACE1, Brain-Renal Risk Factor, Contributes to Kidney Damage in an Alzheimer's Disease Mouse Model.

  • Authors : Shi Y; Department of Nephrology, the First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, Beijing, China.; Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology, Zhengzhou University, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Core Unit of National Clinical Medical Research Center of Kidney Disease, Zhengzhou, China.

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*biosynthesis ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*biosynthesis

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 76 (1), pp. 237-248.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

BACE1 and Other Alzheimer's-Related Biomarkers in Cerebrospinal Fluid and Plasma Distinguish Alzheimer's Disease Patients from Cognitively-Impaired Neurosyphilis Patients.

  • Authors : Zhang M; Department of Neurology, the Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.; Zhong X

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*diagnosis ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*metabolism ; Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 77 (1), pp. 313-322.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPP-β Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer's Disease Models.

  • Authors : Resende R; University of Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Center for Neuroscience and Cell Biology (CNC), Coimbra, Portugal.; University of Coimbra, Institute for Interdisciplinary Research (IIIUC), Coimbra, Portugal.

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Amyloid beta-Peptides/Amyloid beta-Peptides/Amyloid beta-Peptides/*drug effects ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*drug effects

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 76 (4), pp. 1317-1337.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

Synaptic Vesicle Protein 2B Negatively Regulates the Amyloidogenic Processing of AβPP as a Novel Interaction Partner of BACE1.

  • Authors : Miyamoto M; Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.; Department of Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism ; Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/Aspartic Acid Endopeptidases/*metabolism

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2020; Vol. 75 (1), pp. 173-185.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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Academic Journal

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects.

  • Authors : Qiu R; Pfizer Inc, Cambridge, MA, USA.; Ahn JE

Subjects: Protease Inhibitors*/Protease Inhibitors*/Protease Inhibitors*/administration & dosage ; Protease Inhibitors*/Protease Inhibitors*/Protease Inhibitors*/adverse effects ; Protease Inhibitors*/Protease Inhibitors*/Protease Inhibitors*/pharmacokinetics

  • Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2019; Vol. 71 (2), pp. 581-595.Publisher: IOS Press Country of Publication: Netherlands NLM ID: 9814863 Publication Model: Print Cited Medium: Internet

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  • 1-10 of  46 results for ""Aspartic Acid Proteases""