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Academic Journal

Long non-coding RNA XIST regulates chondrogenic differentiation of synovium-derived mesenchymal stem cells from temporomandibular joint via miR-27b-3p/ADAMTS-5 axis.

  • Authors : Zhu Y; College of Stomatology, North China University of Science and Technology, Tangshan 063300, Hebei Province, PR China.; Li R

Subjects: ADAMTS5 Protein/ADAMTS5 Protein/ADAMTS5 Protein/*genetics ; Cell Differentiation/Cell Differentiation/Cell Differentiation/*genetics ; Chondrogenesis/Chondrogenesis/Chondrogenesis/*genetics

  • Source: Cytokine [Cytokine] 2021 Jan; Vol. 137, pp. 155352. Date of Electronic Publication: 2020 Oct 28.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited

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Academic Journal

REST, RCOR1 and RCOR2 expression is reduced in osteoarthritic chondrocytes and contributes to increasing MMP13 and ADAMTS5 expression through upregulating HES1.

  • Authors : Primrose JGB; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand.; Jain L

Subjects: Chondrocytes*/Chondrocytes*/Chondrocytes*/metabolism ; Osteoarthritis*/Osteoarthritis*/Osteoarthritis*/metabolism; Humans

  • Source: Cellular signalling [Cell Signal] 2023 Sep; Vol. 109, pp. 110800. Date of Electronic Publication: 2023 Jul 11.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited

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Academic Journal

Molecular design of new aggrecanases-2 inhibitors.

  • Authors : Shan ZJ; College of Chemistry & Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.; Zhai HL

Subjects: Computer Simulation* ; Drug Design*; ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Oct 01; Vol. 23 (19), pp. 5339-50. Date of Electronic Publication: 2013 Aug 02.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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Academic Journal

Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17.

  • Authors : Ashlin TG; Cardiff School of Biosciences, Cardiff University, Sir Martin Evans Building, Museum Avenue, Cardiff CF10 3AX, United Kingdom.; Kwan AP

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism ; Atherosclerosis/Atherosclerosis/Atherosclerosis/*metabolism ; Macrophages/Macrophages/Macrophages/*metabolism

  • Source: Cytokine [Cytokine] 2013 Oct; Vol. 64 (1), pp. 234-42. Date of Electronic Publication: 2013 Jul 13.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005353 Publication Model: Print-Electronic Cited

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Academic Journal

A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.

  • Authors : Atobe M; Pharmaceutical Research Center, Asahi Kasei Pharma Corporation, 632-1 Mifuku, Izunokuni-shi, Shizuoka 410-2321, Japan. ; Maekawara N

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology ; Thiazoles/Thiazoles/Thiazoles/*pharmacology

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Apr 01; Vol. 23 (7), pp. 2106-10. Date of Electronic Publication: 2013 Feb 09.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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Academic Journal

Design, synthesis and SAR investigation of thienosultam derivatives as ADAMTS-5 (aggrecanase-2) inhibitors.

  • Authors : Atobe M; Pharmaceutical Research Center, Asahi Kasei Pharma Corporation, 632-1 Mifuku, Shizuoka 410-2321, Japan. ; Maekawara N

Subjects: Drug Design*; ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Apr 01; Vol. 23 (7), pp. 2111-6. Date of Electronic Publication: 2013 Feb 09.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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Academic Journal

Structure-activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors.

  • Authors : Peng L; Key Laboratory of Regenerative Biology, Institute of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.; Duan L

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Glutamic Acid/Glutamic Acid/Glutamic Acid/*chemistry ; Oxadiazoles/Oxadiazoles/Oxadiazoles/*chemistry

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Aug 01; Vol. 21 (15), pp. 4457-61. Date of Electronic Publication: 2011 Jun 16.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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Academic Journal

Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis.

  • Authors : De Savi C; Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. ; Pape A

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Formamides/Formamides/Formamides/*chemical synthesis ; Procollagen N-Endopeptidase/Procollagen N-Endopeptidase/Procollagen N-Endopeptidase/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jun 01; Vol. 21 (11), pp. 3301-6. Date of Electronic Publication: 2011 Apr 13.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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Academic Journal

New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold.

  • Authors : Maingot L; INSERM U761 Biostructures and Drug Discovery, Univ. Lille Nord de France.; Leroux F

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Protease Inhibitors/Protease Inhibitors/Protease Inhibitors/*chemical synthesis ; Protease Inhibitors/Protease Inhibitors/Protease Inhibitors/*pharmacology

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Nov 01; Vol. 20 (21), pp. 6213-6. Date of Electronic Publication: 2010 Aug 27.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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Academic Journal

Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors.

  • Authors : Shiozaki M; Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1, Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. ; Imai H

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Cyclopropanes/Cyclopropanes/Cyclopropanes/*chemical synthesis ; Protease Inhibitors/Protease Inhibitors/Protease Inhibitors/*chemical synthesis

  • Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Nov 01; Vol. 19 (21), pp. 6213-7. Date of Electronic Publication: 2009 Sep 03.Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited

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  • 1-10 of  16 results for ""ADAMTS5 Protein""