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Academic Journal

Autophagic degradation of DHCR7 activates AKT3 and promotes sevoflurane-induced hippocampal neuroinflammation in neonatal mice.

  • Authors : Hou Q; Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.; Yuan J

Subjects: Sevoflurane*/Sevoflurane*/Sevoflurane*/pharmacology ; Sevoflurane*/Sevoflurane*/Sevoflurane*/adverse effects ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism

  • Source: Free radical biology & medicine [Free Radic Biol Med] 2024 Sep; Vol. 222, pp. 304-316. Date of Electronic Publication: 2024 Jun 18.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited

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Academic Journal

BCAT1 alleviates early brain injury by inhibiting ferroptosis through PI3K/AKT/mTOR/GPX4 pathway after subarachnoid hemorrhage.

  • Authors : Liu N; Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, China; Key Colleges and Universities Laboratory of Neurosurgery in Heilongjiang Province, Harbin, China

Subjects: Brain Injuries*/Brain Injuries*/Brain Injuries*/metabolism ; Brain Injuries*/Brain Injuries*/Brain Injuries*/pathology ; Brain Injuries*/Brain Injuries*/Brain Injuries*/drug therapy

  • Source: Free radical biology & medicine [Free Radic Biol Med] 2024 Sep; Vol. 222, pp. 173-186. Date of Electronic Publication: 2024 Jun 11.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited

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Academic Journal

Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway.

  • Authors : Ma C; Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.; Huang J

Subjects: Th1 Cells*/Th1 Cells*/Th1 Cells*/immunology ; Th17 Cells*/Th17 Cells*/Th17 Cells*/immunology ; Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Aug 20; Vol. 137, pp. 112360. Date of Electronic Publication: 2024 Jun 08.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited

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Academic Journal

BI-7273, a BRD9 inhibitor, reduces lipid accumulation by downregulating the AKT/mTOR/SREBP1 signaling pathway.

  • Authors : Li Y; Laboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, 199 South Chang'an Road, Xi'an 710062, Shaanxi, PR China.; He Q

Subjects: Lipid Metabolism*/Lipid Metabolism*/Lipid Metabolism*/drug effects ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/metabolism ; Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/Proto-Oncogene Proteins c-akt*/antagonists & inhibitors

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Aug; Vol. 226, pp. 116412. Date of Electronic Publication: 2024 Jul 05.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

MICAL-L2, as an estrogen-responsive gene, is involved in ER-positive breast cancer cell progression and tamoxifen sensitivity via the AKT/mTOR pathway.

  • Authors : Wen P; Department of Pathophysiology, Jinzhou Medical University, Jinzhou 121001, China; Biological Anthropology Institute, Jinzhou Medical University, Jinzhou 121001, China. Electronic address: .

Subjects: Tamoxifen*/Tamoxifen*/Tamoxifen*/pharmacology ; Tamoxifen*/Tamoxifen*/Tamoxifen*/therapeutic use ; TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Jul; Vol. 225, pp. 116256. Date of Electronic Publication: 2024 May 09.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress.

  • Authors : Kamel NM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. Electronic address: .; El-Sayed SS

Subjects: NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/NF-E2-Related Factor 2*/metabolism ; TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/TOR Serine-Threonine Kinases*/metabolism ; Kelch-Like ECH-Associated Protein 1*/Kelch-Like ECH-Associated Protein 1*/Kelch-Like ECH-Associated Protein 1*/metabolism

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112781. Date of Electronic Publication: 2024 Jul 25.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited

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Academic Journal

Isorhapontigenin delays senescence and matrix degradation of nucleus pulposus cells via PI3K/AKT/mTOR-mediated autophagy pathway in vitro and alleviates intervertebral disc degeneration in vivo.

  • Authors : Wang Z; Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou, Zhejiang Province, China

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/drug therapy ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Nucleus Pulposus*/Nucleus Pulposus*/Nucleus Pulposus*/drug effects

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112717. Date of Electronic Publication: 2024 Jul 26.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited

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Academic Journal

Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway.

  • Authors : Qin Y; Department of Emergency and Critical Care Medicine, The First Afliated Hospital of Chongqing Medical University, Chongqing 400016, PR China.; Li W

Subjects: Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/drug therapy ; Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/metabolism ; Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/pathology

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112719. Date of Electronic Publication: 2024 Jul 20.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited

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Academic Journal

Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.

  • Authors : Sun B; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Subjects: Epithelial-Mesenchymal Transition*/Epithelial-Mesenchymal Transition*/Epithelial-Mesenchymal Transition*/drug effects ; Asthma*/Asthma*/Asthma*/drug therapy ; Asthma*/Asthma*/Asthma*/metabolism

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112624. Date of Electronic Publication: 2024 Jul 13.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited

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Academic Journal

Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.

  • Authors : Wang Y; School of Clinical Medicine, Guizhou Medical University, No.9 Beijing Road, Yunyan District, Guiyang 550004, Guizhou, China.; Chen SJ

Subjects: Quercetin*/Quercetin*/Quercetin*/analogs & derivatives ; Quercetin*/Quercetin*/Quercetin*/pharmacology ; Quercetin*/Quercetin*/Quercetin*/therapeutic use

  • Source: International immunopharmacology [Int Immunopharmacol] 2024 Sep 10; Vol. 138, pp. 112517. Date of Electronic Publication: 2024 Jun 25.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited

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  • 1-10 of  1,851 results for ""Proto-Oncogene Proteins c-akt""