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Academic Journal

MEK1/2 promote ROS production and deubiquitinate NLRP3 independent of ERK1/2 during NLRP3 inflammasome activation.

  • Authors : Chen H; Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310009, PR China.; Xie S

Subjects: NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/genetics ; Reactive Oxygen Species*/Reactive Oxygen Species*/Reactive Oxygen Species*/metabolism

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Dec; Vol. 230 (Pt 1), pp. 116572. Date of Electronic Publication: 2024 Oct 11.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Design, synthesis and biological evaluation of imidazopyridazine derivatives containing isoquinoline group as potent MNK1/2 inhibitors.

  • Authors : Bu H; Center of Drug Discovery, State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.; Yuan X

Subjects: Drug Design*; Imidazoles/Imidazoles/Imidazoles/*pharmacology ; Isoquinolines/Isoquinolines/Isoquinolines/*pharmacology

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2021 Jun 15; Vol. 40, pp. 116186. Date of Electronic Publication: 2021 May 02.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.

  • Authors : Van Dort ME; Center for Molecular Imaging, The University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.

Subjects: Phosphoinositide-3 Kinase Inhibitors*; Drug Delivery Systems/Drug Delivery Systems/Drug Delivery Systems/*methods ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*administration & dosage

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2015 Apr 01; Vol. 23 (7), pp. 1386-94. Date of Electronic Publication: 2015 Mar 06.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2.

  • Authors : Zhang H; Department of Microbiology, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, PR China.; Feng H

Subjects: Host-Pathogen Interactions* ; Virus Replication*; Herpesvirus 2, Human/Herpesvirus 2, Human/Herpesvirus 2, Human/*physiology

  • Source: Virus research [Virus Res] 2010 Jun; Vol. 150 (1-2), pp. 22-7. Date of Electronic Publication: 2010 Feb 19.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8410979 Publication Model: Print-Electronic Cited

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Academic Journal

Cyanidin suppresses ultraviolet B-induced COX-2 expression in epidermal cells by targeting MKK4, MEK1, and Raf-1.

  • Authors : Kim JE; WCU, Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Republic of Korea.; Kwon JY

Subjects: Anthocyanins/Anthocyanins/Anthocyanins/*pharmacology ; Cyclooxygenase 2/Cyclooxygenase 2/Cyclooxygenase 2/*drug effects ; Epidermis/Epidermis/Epidermis/*drug effects

  • Source: Biochemical pharmacology [Biochem Pharmacol] 2010 May 15; Vol. 79 (10), pp. 1473-82. Date of Electronic Publication: 2010 Jan 21.Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors.

  • Authors : Berger DM; Chemical & Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. ; Dutia M

Subjects: Alkenes/Alkenes/Alkenes/*chemistry ; Aniline Compounds/Aniline Compounds/Aniline Compounds/*chemistry ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Oct 15; Vol. 16 (20), pp. 9202-11. Date of Electronic Publication: 2008 Sep 09.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Discovery of N-(benzyloxy)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives as potential antiproliferative agents by inhibiting MEK.

  • Authors : Lv XH; School of Science, Anhui Agricultural University, Hefei 230036, PR China; School of Plant Protection, Anhui Agricultural University, Hefei 230036, PR China.

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*chemistry ; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*antagonists & inhibitors

  • Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Oct 01; Vol. 24 (19), pp. 4652-4659. Date of Electronic Publication: 2016 Aug 03.Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command.

  • Authors : Caravagna C; Department of Pediatrics, Laval University, Centre de Recherche du Centre Hospitalier Universitaire (CHU) de Québec, Hôpital St-François d'Assise, 10 Rue de l'Espinay, Québec, QC G1L 3L5, Canada. Electronic address: .; Soliz J

Subjects: Central Nervous System/Central Nervous System/Central Nervous System/*physiology ; Erythropoietin/Erythropoietin/Erythropoietin/*metabolism ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*metabolism

  • Source: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2015 Jan 15; Vol. 206, pp. 36-40. Date of Electronic Publication: 2014 Nov 21.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 101140022 Publication Model: Print-Electronic Cited

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Academic Journal

Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.

  • Authors : Sari AN; Department of Pharmacology, Faculty of Pharmacy, Yenisehir Campus, Mersin University, 33169 Mersin, Turkey.; Kacan M

Subjects: MAP Kinase Signaling System*; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*metabolism ; Nitric Oxide Synthase Type II/Nitric Oxide Synthase Type II/Nitric Oxide Synthase Type II/*metabolism

  • Source: European journal of pharmacology [Eur J Pharmacol] 2014 Jan 15; Vol. 723, pp. 234-45. Date of Electronic Publication: 2013 Dec 01.Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited

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Academic Journal

Activation of MEK 1/2 and p42/44 MAPK by angiotensin II in hepatocyte nucleus and their potentiation by ethanol.

  • Authors : Aroor AR; Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO 65212, USA.; Lee YJ

Subjects: Angiotensin II/Angiotensin II/Angiotensin II/*physiology ; Ethanol/Ethanol/Ethanol/*pharmacology ; MAP Kinase Kinase 1/MAP Kinase Kinase 1/MAP Kinase Kinase 1/*metabolism

  • Source: Alcohol (Fayetteville, N.Y.) [Alcohol] 2009 Jun; Vol. 43 (4), pp. 315-22.Publisher: Elsevier Science Country of Publication: United States NLM ID: 8502311 Publication Model: Print Cited Medium:

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  • 1-10 of  67 results for ""MAP Kinase Kinase 1""