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Academic Journal

Hes1 marks peri-condensation mesenchymal cells that generate both chondrocytes and perichondrial cells in early bone development.

  • Authors : Matsushita Y; Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, Texas, USA; Department of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Subjects: Bone and Bones*/Bone and Bones*/Bone and Bones*/cytology ; Bone Development* ; Cartilage*/Cartilage*/Cartilage*/cytology

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Jun; Vol. 299 (6), pp. 104805. Date of Electronic Publication: 2023 May 11.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Notch inhibitor screening reveals an unexpected HES1 heterodimer.

Subjects: High-Throughput Screening Assays*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Neoplasms/Neoplasms/Neoplasms/*drug therapy

  • Source: The Journal of biological chemistry [J Biol Chem] 2018 May 25; Vol. 293 (21), pp. 8295-8296.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone.

  • Authors : Perron A; Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Uji, Kyoto 611-0011.

Subjects: High-Throughput Screening Assays*; Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Apoptosis/Apoptosis/Apoptosis/*drug effects

  • Source: The Journal of biological chemistry [J Biol Chem] 2018 May 25; Vol. 293 (21), pp. 8285-8294. Date of Electronic Publication: 2018 Mar 09.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Hairy and enhancer of split 1 (HES1) protects cells from endoplasmic reticulum stress-induced apoptosis through repression of GADD34 .

  • Authors : Lee JE; From the Department of Biology and the Center for Cell and Genome Science, University of Utah, Salt Lake City, Utah 84112.; Morrison W

Subjects: Apoptosis* ; Endoplasmic Reticulum Stress*; Protein Phosphatase 1/Protein Phosphatase 1/Protein Phosphatase 1/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2018 Apr 20; Vol. 293 (16), pp. 5947-5955. Date of Electronic Publication: 2018 Feb 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function.

  • Authors : Yu J; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, USA; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut, USA.

Subjects: Cell Differentiation/Cell Differentiation/Cell Differentiation/*physiology ; Osteoclasts/Osteoclasts/Osteoclasts/*cytology ; Receptor, Notch2/Receptor, Notch2/Receptor, Notch2/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101376. Date of Electronic Publication: 2021 Nov 03.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

The E3 ubiquitin ligase SCF FBXL14 complex stimulates neuronal differentiation by targeting the Notch signaling factor HES1 for proteolysis.

  • Authors : Chen F; Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, Shenzhen, Guangdong 518055, China; Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen 518036, China.

Subjects: F-Box Proteins/F-Box Proteins/F-Box Proteins/*physiology ; Neurons/Neurons/Neurons/*cytology ; SKP Cullin F-Box Protein Ligases/SKP Cullin F-Box Protein Ligases/SKP Cullin F-Box Protein Ligases/*physiology

  • Source: The Journal of biological chemistry [J Biol Chem] 2017 Dec 08; Vol. 292 (49), pp. 20100-20112. Date of Electronic Publication: 2017 Oct 25.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

NOTCH2 promotes osteoclast maturation and metabolism and modulates the transcriptome profile during osteoclastogenesis.

  • Authors : Canalis E; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut, USA; Department of Medicine, UConn Health, Farmington, Connecticut, USA

Subjects: Osteoclasts*/Osteoclasts*/Osteoclasts*/cytology ; Osteoclasts*/Osteoclasts*/Osteoclasts*/metabolism ; Osteogenesis*/Osteogenesis*/Osteogenesis*/genetics

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Feb; Vol. 300 (2), pp. 105613. Date of Electronic Publication: 2023 Dec 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.

  • Authors : Kindermann B; Leibniz Institut für Alternsforschung-Fritz Lipmann Institut, 07745 Jena, Germany.; Valkova C

Subjects: Signal Transduction*; Nuclear Pore Complex Proteins/Nuclear Pore Complex Proteins/Nuclear Pore Complex Proteins/*metabolism ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*pathology

  • Source: The Journal of biological chemistry [J Biol Chem] 2019 Aug 02; Vol. 294 (31), pp. 11741-11750. Date of Electronic Publication: 2019 Jun 11.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells.

  • Authors : Farah E; Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907.; Li C

Subjects: Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/Drug Resistance, Neoplasm/*drug effects ; Phenylthiohydantoin/Phenylthiohydantoin/Phenylthiohydantoin/*analogs & derivatives ; Receptor, Notch1/Receptor, Notch1/Receptor, Notch1/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2019 May 24; Vol. 294 (21), pp. 8543-8554. Date of Electronic Publication: 2019 Apr 02.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

The Hajdu Cheney mutation sensitizes mice to the osteolytic actions of tumor necrosis factor α.

  • Authors : Yu J; Department of Orthopaedic Surgery, UConn Health, Farmington, Connecticut 06030.; UConn Musculoskeletal Institute, UConn Health, Farmington, Connecticut 06030.

Subjects: Mutation*; Hajdu-Cheney Syndrome/Hajdu-Cheney Syndrome/Hajdu-Cheney Syndrome/*genetics ; Osteoclasts/Osteoclasts/Osteoclasts/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2019 Sep 27; Vol. 294 (39), pp. 14203-14214. Date of Electronic Publication: 2019 Aug 01.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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  • 1-10 of  41 results for ""Transcription Factor HES-1""