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Academic Journal

Three Tyrosine Residues in the Erythropoietin Receptor Are Essential for Janus Kinase 2 V617F Mutant-induced Tumorigenesis.

  • Authors : Ueda F; From the Division of Hygienic Chemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512.; Tago K

Subjects: Mutation, Missense* ; Signal Transduction*; Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2017 Feb 03; Vol. 292 (5), pp. 1826-1846. Date of Electronic Publication: 2016 Dec 20.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.

  • Authors : Heir P; From the Departments of Laboratory Medicine and Pathobiology and.; Srikumar T

Subjects: Proteolysis* ; Signal Transduction* ; Ubiquitination*

  • Source: The Journal of biological chemistry [J Biol Chem] 2016 Apr 01; Vol. 291 (14), pp. 7357-72. Date of Electronic Publication: 2016 Feb 04.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.

  • Authors : Javadi M; Ontario Cancer Institute, Campbell Family Cancer Research Institute, Toronto, Ontario M5G 2M9, Canada.; Hofstätter E

Subjects: Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Receptors, Erythropoietin/Receptors, Erythropoietin/Receptors, Erythropoietin/*metabolism; Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/chemistry

  • Source: The Journal of biological chemistry [J Biol Chem] 2012 Jul 27; Vol. 287 (31), pp. 26223-34. Date of Electronic Publication: 2012 Jun 05.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.

  • Authors : Rogers H; Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1822, USA.; Wang L

Subjects: Gene Expression Regulation*; Basic Helix-Loop-Helix Transcription Factors/Basic Helix-Loop-Helix Transcription Factors/Basic Helix-Loop-Helix Transcription Factors/*metabolism ; Polycythemia/Polycythemia/Polycythemia/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2012 Oct 26; Vol. 287 (44), pp. 36720-31. Date of Electronic Publication: 2012 Sep 16.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor.

  • Authors : Bulut GB; Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.; Sulahian R

Subjects: Endosomes/Endosomes/Endosomes/*metabolism ; Receptors, Erythropoietin/Receptors, Erythropoietin/Receptors, Erythropoietin/*metabolism ; Signal Transduction/Signal Transduction/Signal Transduction/*physiology

  • Source: The Journal of biological chemistry [J Biol Chem] 2011 Feb 25; Vol. 286 (8), pp. 6449-57. Date of Electronic Publication: 2010 Dec 23.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

STAT5 activation is critical for the transformation mediated by myeloproliferative disorder-associated JAK2 V617F mutant.

  • Authors : Funakoshi-Tago M; Department of Biochemistry, Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, USA. ; Tago K

Subjects: Mutation, Missense*; Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/*metabolism ; Janus Kinase 2/Janus Kinase 2/Janus Kinase 2/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2010 Feb 19; Vol. 285 (8), pp. 5296-307. Date of Electronic Publication: 2009 Dec 22.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation.

  • Authors : Zhao L; Department of Cell Biology, University of Texas SouthwesternMedical Center, Dallas, Texas 75390, USA.; Dong H

Subjects: Signal Transduction* ; src Homology Domains*; Janus Kinase 2/Janus Kinase 2/Janus Kinase 2/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2009 Sep 25; Vol. 284 (39), pp. 26988-98. Date of Electronic Publication: 2009 Jul 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

TRPC3 activation by erythropoietin is modulated by TRPC6.

  • Authors : Hirschler-Laszkiewicz I; Department of Pediatrics, the Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA.; Tong Q

Subjects: Calcium Signaling/Calcium Signaling/Calcium Signaling/*physiology ; Cell Differentiation/Cell Differentiation/Cell Differentiation/*physiology ; Erythroid Precursor Cells/Erythroid Precursor Cells/Erythroid Precursor Cells/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2009 Feb 13; Vol. 284 (7), pp. 4567-81. Date of Electronic Publication: 2008 Dec 13.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F.

  • Authors : Lu X; Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.; Huang LJ

Subjects: Amino Acid Substitution*; Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/*metabolism ; Janus Kinase 2/Janus Kinase 2/Janus Kinase 2/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2008 Feb 29; Vol. 283 (9), pp. 5258-66. Date of Electronic Publication: 2007 Dec 23.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation.

  • Authors : Chen ZY; Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1822, USA.; Asavaritikrai P

Subjects: Cell Proliferation*; Apoptosis/Apoptosis/Apoptosis/*physiology ; Brain/Brain/Brain/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2007 Aug 31; Vol. 282 (35), pp. 25875-83. Date of Electronic Publication: 2007 Jun 28.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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