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Academic Journal

Identification of PS1/gamma-secretase and glutamate transporter GLT-1 interaction sites.

  • Authors : Perrin F; MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.; Sinha P

Subjects: Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/chemistry ; Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/genetics ; Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2024 Apr; Vol. 300 (4), pp. 107172. Date of Electronic Publication: 2024 Mar 16.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Leucine 434 is essential for docosahexaenoic acid-induced augmentation of L-glutamate transporter current.

  • Authors : Takahashi K; Laboratory of Neuropharmacology, Division of Pharmacology, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan.; Chen L

Subjects: Docosahexaenoic Acids*/Docosahexaenoic Acids*/Docosahexaenoic Acids*/metabolism ; Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/genetics ; Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/Excitatory Amino Acid Transporter 2*/metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2023 Jan; Vol. 299 (1), pp. 102793. Date of Electronic Publication: 2022 Dec 09.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity.

  • Authors : Pajarillo E; Department of Pharmaceutical Sciences, Florida A&M University, Tallahassee, Florida, USA.; Digman A

Subjects: Dopaminergic Neurons/Dopaminergic Neurons/Dopaminergic Neurons/*metabolism ; Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/*metabolism ; Manganese/Manganese/Manganese/*pharmacology

  • Source: The Journal of biological chemistry [J Biol Chem] 2021 Dec; Vol. 297 (6), pp. 101372. Date of Electronic Publication: 2021 Oct 29.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates.

  • Authors : Kolen B; Molekular- und Zellphysiologie (IBI-1), Institute of Biological Information Processing, Forschungszentrum Jülich, Jülich, Germany.; Kortzak D

Subjects: Point Mutation*; Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/*metabolism ; Glutamic Acid/Glutamic Acid/Glutamic Acid/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2020 Oct 30; Vol. 295 (44), pp. 14936-14947. Date of Electronic Publication: 2020 Aug 20.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2).

  • Authors : Damm-Ganamet KL; Discovery Sciences, Janssen Research and Development, San Diego, California 92121. Electronic address: .; Rives ML

Subjects: Amino Acid Transport System X-AG/Amino Acid Transport System X-AG/Amino Acid Transport System X-AG/*antagonists & inhibitors ; Binding Sites/Binding Sites/Binding Sites/*drug effects ; Central Nervous System Diseases/Central Nervous System Diseases/Central Nervous System Diseases/*drug therapy

  • Source: The Journal of biological chemistry [J Biol Chem] 2020 Mar 27; Vol. 295 (13), pp. 4359-4366. Date of Electronic Publication: 2020 Feb 20.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

A K + /Na + co-binding state: Simultaneous versus competitive binding of K + and Na + to glutamate transporters.

  • Authors : Wang J; Department of Chemistry, Binghamton University, Binghamton, New York 13902.; Zielewicz L

Subjects: Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/*metabolism ; Potassium/Potassium/Potassium/*metabolism ; Sodium/Sodium/Sodium/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2019 Aug 09; Vol. 294 (32), pp. 12180-12190. Date of Electronic Publication: 2019 Jun 24.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Both reentrant loops of the sodium-coupled glutamate transporters contain molecular determinants of cation selectivity.

  • Authors : Silverstein N; the Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada Faculty of Medicine, Hebrew University, Jerusalem 91120, Israel.; Sliman A

Subjects: Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/*metabolism ; Sodium/Sodium/Sodium/*metabolism; Binding Sites

  • Source: The Journal of biological chemistry [J Biol Chem] 2018 Sep 14; Vol. 293 (37), pp. 14200-14209. Date of Electronic Publication: 2018 Jul 19.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Diabetes Impairs Wnt3 Protein-induced Neurogenesis in Olfactory Bulbs via Glutamate Transporter 1 Inhibition.

  • Authors : Wakabayashi T; From the Stem Cell Engineering Research Group, Biotechnology Research Institute for Drug Discovery, Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565 and.; Hidaka R

Subjects: Neurogenesis*/Neurogenesis*/Neurogenesis*/drug effects; Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/Diabetes Mellitus, Experimental/*metabolism ; Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/Excitatory Amino Acid Transporter 2/*antagonists & inhibitors

  • Source: The Journal of biological chemistry [J Biol Chem] 2016 Jul 15; Vol. 291 (29), pp. 15196-211. Date of Electronic Publication: 2016 May 20.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1.

  • Authors : Tanui R; From the Department of Chemistry Binghamton University, Binghamton, New York 13902 and.; Tao Z

Subjects: Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/*metabolism ; Glutamic Acid/Glutamic Acid/Glutamic Acid/*metabolism ; Sodium/Sodium/Sodium/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2016 May 27; Vol. 291 (22), pp. 11852-64. Date of Electronic Publication: 2016 Apr 04.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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Academic Journal

Neuregulin 1 Controls Glutamate Uptake by Up-regulating Excitatory Amino Acid Carrier 1 (EAAC1).

  • Authors : Yu HN; From the Department of Anatomy and Neuroscience, College of Medicine, Eulji University, Daejeon, 301-746, Republic of Korea.; Park WK

Subjects: Up-Regulation*; Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/Excitatory Amino Acid Transporter 3/*physiology ; Glutamic Acid/Glutamic Acid/Glutamic Acid/*metabolism

  • Source: The Journal of biological chemistry [J Biol Chem] 2015 Aug 14; Vol. 290 (33), pp. 20233-44. Date of Electronic Publication: 2015 Jun 19.Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID:

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