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Academic Journal

An engineered DNA aptamer-based PROTAC for precise therapy of p53-R175H hotspot mutant-driven cancer.

  • Authors : Kong L; Department of Medical Oncology, Tianjin Medical University General Hospital, Tianjin 300052, China.; Meng F

Subjects: Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/genetics ; Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/metabolism ; Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/pharmacology

  • Source: Science bulletin [Sci Bull (Beijing)] 2024 Jul 15; Vol. 69 (13), pp. 2122-2135. Date of Electronic Publication: 2024 May 18.Publisher: Elsevier B.V. Country of Publication: Netherlands NLM ID: 101655530 Publication Model: Print-Electronic Cited

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Academic Journal

Targeting the undruggables-the power of protein degraders.

  • Authors : Zhang C; Changping Laboratory, Beijing 102206, China.; Liu Y

Subjects: Proteolysis*/Proteolysis*/Proteolysis*/drug effects ; Autophagy*/Autophagy*/Autophagy*/drug effects; Humans

  • Source: Science bulletin [Sci Bull (Beijing)] 2024 Jun 15; Vol. 69 (11), pp. 1776-1797. Date of Electronic Publication: 2024 Mar 29.Publisher: Elsevier B.V. Country of Publication: Netherlands NLM ID: 101655530 Publication Model: Print-Electronic Cited

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Academic Journal

Proteolysis of the pericellular matrix: Pinpointing the role and involvement of matrix metalloproteinases in early osteoarthritic remodeling.

Subjects: MATRIX metalloproteinases; ARTICULAR cartilage; SPATIAL arrangement

  • Source: Acta Biomaterialia; Jun2024, Vol. 181, p297-307, 11p

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Academic Journal

Creating a path during melanoma amoeboid migration: When too crowded, start worrying.

Subjects: *PROTEOLYSIS; *EXTRACELLULAR matrix; *CANCER cells

  • Source: Developmental Cell. Sep2024, Vol. 59 Issue 18, p2395-2397. 3p.

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Academic Journal

Lighting the way to tumor destruction.

Subjects: *PROTEOLYSIS; *TUMORS

  • Source: Trends in Pharmacological Sciences. Nov2023, Vol. 44 Issue 11, p750-752. 3p.

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Academic Journal

Boosting stability and therapeutic potential of proteolysis-resistant antimicrobial peptides by end-tagging β-naphthylalanine.

Subjects: ANTIMICROBIAL peptides; BACTERIAL cell membranes; PEPTIDE antibiotics

  • Source: Acta Biomaterialia; Jul2023, Vol. 164, p175-194, 20p

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Academic Journal

ProteoCure: A European network to fine-tune the proteome.

Subjects: *PROTEOLYSIS; *RESEARCH personnel; *BIOTECHNOLOGYEUROPE

  • Source: Biochimie. Nov2024, Vol. 226, p4-9. 6p.

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Academic Journal

The A1/A2 β-casein genotype of cows, but not their horn status, influences peptide generation during simulated digestion of milk.

Subjects: PROTEOLYSIS; COMPOSITION of milk; HILL farming

  • Source: Journal of Dairy Science. Sep2024, Vol. 107 Issue 9, p6425-6436. 12p.

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Academic Journal

Advancing targeted protein degradation modalities.

Subjects: *PROTEOLYSIS

  • Source: Trends in Pharmacological Sciences. Nov2023, Vol. 44 Issue 11, p743-745. 3p.

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Academic Journal

The promise of targeted protein degradation approaches.

Subjects: *PROTEOLYSIS

  • Source: Trends in Pharmacological Sciences. Nov2023, Vol. 44 Issue 11, p746-749. 4p.

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  • 1-10 of  10,585 results for ""Proteolysis""