Search Results

Display Settings
Results per page: 10
Sort By: Relevance
Filter
  • 1-10 of  870 results for ""Small Molecule Libraries""

Your Filters

Publisher : elsevier
Reset filters
Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request
Academic Journal

Clinical applications of small-molecule GABA A R modulators for neurological disorders.

  • Authors : Chen G; Department of Neurosurgery, China-Japan Union Hospital of Jilin University, Changchun, China.; Xu M

Subjects: Receptors, GABA-A*/Receptors, GABA-A*/Receptors, GABA-A*/metabolism ; Nervous System Diseases*/Nervous System Diseases*/Nervous System Diseases*/drug therapy ; Nervous System Diseases*/Nervous System Diseases*/Nervous System Diseases*/metabolism

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Dec; Vol. 153, pp. 107983. Date of Electronic Publication: 2024 Nov 22.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Identification of protein partners for small molecules reshapes the understanding of nonalcoholic steatohepatitis and drug discovery.

  • Authors : Wang D; School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.; Wang Y

Subjects: Drug Discovery* ; Fatty Liver*/Fatty Liver*/Fatty Liver*/metabolism ; Proteolysis Targeting Chimera*/Proteolysis Targeting Chimera*/Proteolysis Targeting Chimera*/chemistry

  • Source: Life sciences [Life Sci] 2024 Nov 01; Vol. 356, pp. 123031. Date of Electronic Publication: 2024 Sep 01.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Identification of small molecule antagonists of sonic hedgehog/heparin binding with activity in hedgehog functional assays.

  • Authors : Lamson DR; Biomanufacturing Research Institute and Technology Enterprise, USA.; Tarpley M

Subjects: Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/metabolism ; Hedgehog Proteins*/Hedgehog Proteins*/Hedgehog Proteins*/antagonists & inhibitors ; Heparin*/Heparin*/Heparin*/metabolism

  • Source: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2024 Nov; Vol. 1868 (11), pp. 130692. Date of Electronic Publication: 2024 Aug 14.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731726 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Identification of imidazole-based small molecules to combat cognitive disability caused by Alzheimer's disease: A molecular docking and MD simulations based approach.

  • Authors : Haque A; Department of Chemistry, College of Science, University of Hail, Kingdom of Saudi Arabia. Electronic address: .; Alenezi KM

Subjects: Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/drug therapy ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism ; Imidazoles*/Imidazoles*/Imidazoles*/chemistry

  • Source: Computational biology and chemistry [Comput Biol Chem] 2024 Oct; Vol. 112, pp. 108152. Date of Electronic Publication: 2024 Jul 18.Publisher: Elsevier Country of Publication: England NLM ID: 101157394 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Characterization of a small molecule inhibitor of the NLRP3 inflammasome and its potential use for acute lung injury.

  • Authors : Xu Y; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA 23298, USA.; Biby S

Subjects: NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism ; Acute Lung Injury*/Acute Lung Injury*/Acute Lung Injury*/drug therapy

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107562. Date of Electronic Publication: 2024 Jun 17.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Investigation of F508del CFTR unfolding and a search for stabilizing small molecules.

  • Authors : Meng X; University of Manchester, School of Biological Sciences, Oxford Road, Manchester, M13 9PL, UK; The Francis Crick Institute, Cellular Degradation Systems Lab, 1 Midland Road, London, NW1 1AT, UK.

Subjects: Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/chemistry ; Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/genetics ; Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/Cystic Fibrosis Transmembrane Conductance Regulator*/metabolism

  • Source: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2024 Aug; Vol. 758, pp. 110050. Date of Electronic Publication: 2024 Jun 12.Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Discovery of two non-UDP-mimic inhibitors of O-GlcNAc transferase by screening a DNA-encoded library.

  • Authors : Balsollier C; Department of Chemical Biology & Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht NL-3508 TB, The Netherlands; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia.

Subjects: N-Acetylglucosaminyltransferases*/N-Acetylglucosaminyltransferases*/N-Acetylglucosaminyltransferases*/antagonists & inhibitors ; N-Acetylglucosaminyltransferases*/N-Acetylglucosaminyltransferases*/N-Acetylglucosaminyltransferases*/metabolism ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/pharmacology

  • Source: Bioorganic chemistry [Bioorg Chem] 2024 Jun; Vol. 147, pp. 107321. Date of Electronic Publication: 2024 Mar 29.Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Covalent fragment libraries in drug discovery-Design, synthesis, and screening methods.

  • Authors : Hocking B; Department of Life Sciences, Imperial College London, London, United Kingdom.; Armstrong A

Subjects: Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/pharmacology ; Drug Discovery*; Drug Design

  • Source: Progress in medicinal chemistry [Prog Med Chem] 2023; Vol. 62, pp. 105-146. Date of Electronic Publication: 2023 Nov 13.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376452 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes.

Subjects: Drug Design* ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/antagonists & inhibitors ; HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/HSP90 Heat-Shock Proteins*/chemistry

  • Source: Journal of molecular biology [J Mol Biol] 2022 Sep 15; Vol. 434 (17), pp. 167468. Date of Electronic Publication: 2022 Jan 29.Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
Academic Journal

Small-molecule modulators of protein-RNA interactions.

  • Authors : Byun WG; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea(South).; Lim D

Subjects: RNA-Binding Proteins* ; Small Molecule Libraries*/Small Molecule Libraries*/Small Molecule Libraries*/pharmacology; Humans

  • Source: Current opinion in chemical biology [Curr Opin Chem Biol] 2022 Jun; Vol. 68, pp. 102149. Date of Electronic Publication: 2022 May 06.Publisher: Elsevier Country of Publication: England NLM ID: 9811312 Publication Model: Print-Electronic Cited Medium:

Record details

Read More Add to Saved list
×
  • 1-10 of  870 results for ""Small Molecule Libraries""