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Academic Journal

TMF inhibits extracellular matrix degradation by regulating the C/EBPβ/ADAMTS5 signaling pathway in osteoarthritis.

  • Authors : Wang Z; College of Rehabilitation, Gannan Medical University, Ganzhou 341000, China.; Shi W

Subjects: ADAMTS5 Protein*/ADAMTS5 Protein*/ADAMTS5 Protein*/metabolism ; ADAMTS5 Protein*/ADAMTS5 Protein*/ADAMTS5 Protein*/genetics ; Extracellular Matrix*/Extracellular Matrix*/Extracellular Matrix*/metabolism

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 May; Vol. 174, pp. 116501. Date of Electronic Publication: 2024 Mar 29.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic

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Academic Journal

Selection and characterization of DNA aptamers inhibiting a druggable target of osteoarthritis, ADAMTS-5.

  • Authors : Yu Y; School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, PR China; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, PR China.

Subjects: Aptamers, Nucleotide*/Aptamers, Nucleotide*/Aptamers, Nucleotide*/pharmacology ; Osteoarthritis*/Osteoarthritis*/Osteoarthritis*/drug therapy; ADAMTS4 Protein/ADAMTS4 Protein/ADAMTS4 Protein/chemistry

  • Source: Biochimie [Biochimie] 2022 Oct; Vol. 201, pp. 168-176. Date of Electronic Publication: 2022 Jun 11.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic

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Academic Journal

Caffeic acid protects against IL-1β-induced inflammatory responses and cartilage degradation in articular chondrocytes.

  • Authors : Huang X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. Electronic address: .; Xi Y

Subjects: Caffeic Acids/Caffeic Acids/Caffeic Acids/*pharmacology ; Cartilage, Articular/Cartilage, Articular/Cartilage, Articular/*pathology ; Chondrocytes/Chondrocytes/Chondrocytes/*pathology

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Nov; Vol. 107, pp. 433-439. Date of Electronic Publication: 2018 Aug 10.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic

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Academic Journal

Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo.

  • Authors : Chen J; Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, People's Republic of China.; Xuan J

Subjects: Oxidative Stress*/Oxidative Stress*/Oxidative Stress*/drug effects; Extracellular Matrix/Extracellular Matrix/Extracellular Matrix/*metabolism ; Inflammation/Inflammation/Inflammation/*pathology

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2017 Jul; Vol. 91, pp. 208-219. Date of Electronic Publication: 2017 Apr 28.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic

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Academic Journal

Ghrelin prevents articular cartilage matrix destruction in human chondrocytes.

  • Authors : Liu J; Orthopaedic Department, People's Hospital of Gansu Provincial, Lanzhou, 730000, China. Electronic address: .; Cao L

Subjects: Cartilage, Articular/Cartilage, Articular/Cartilage, Articular/*drug effects ; Chondrocytes/Chondrocytes/Chondrocytes/*drug effects ; Ghrelin/Ghrelin/Ghrelin/*pharmacology

  • Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Feb; Vol. 98, pp. 651-655. Date of Electronic Publication: 2018 Jan 04.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic

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Academic Journal

Discovery of a benzimidazole series of ADAMTS-5 (aggrecanase-2) inhibitors by scaffold hopping.

  • Authors : Sogame S; Pharmaceutical Research Center, Asahi Kasei Pharma Corporation, 632-1 Mifuku, Izunokuni-shi, Shizuoka 410-2321, Japan.; Suenaga Y

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Benzimidazoles/Benzimidazoles/Benzimidazoles/*chemistry ; Benzimidazoles/Benzimidazoles/Benzimidazoles/*pharmacology

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2014 Jan; Vol. 71, pp. 250-8. Date of Electronic Publication: 2013 Nov 15.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic

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Academic Journal

Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group.

  • Authors : Maingot L; INSERM U761, Biostructures and Drug Discovery, France; Faculté de Pharmacie, Univ Lille Nord de France, 3 rue du Pr Laguesse, Lille F-59006, France

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*pharmacology

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2013 Nov; Vol. 69, pp. 244-61. Date of Electronic Publication: 2013 Aug 30.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic

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Academic Journal

Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.

  • Authors : Filou S; Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.; Stylianou M

Subjects: Gene Expression Regulation, Neoplastic*; ADAM Proteins/ADAM Proteins/ADAM Proteins/*genetics ; ADAM Proteins/ADAM Proteins/ADAM Proteins/*metabolism

  • Source: Biochimie [Biochimie] 2013 Apr; Vol. 95 (4), pp. 725-34. Date of Electronic Publication: 2012 Nov 03.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic

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Academic Journal

Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.

  • Authors : Nuti E; Dipartimento di Farmacia, Università di Pisa, via Bonanno 6, 56126 Pisa, Italy.; Santamaria S

Subjects: ADAM Proteins/ADAM Proteins/ADAM Proteins/*antagonists & inhibitors ; Matrix Metalloproteinase Inhibitors/Matrix Metalloproteinase Inhibitors/Matrix Metalloproteinase Inhibitors/*pharmacology ; Matrix Metalloproteinases/Matrix Metalloproteinases/Matrix Metalloproteinases/*metabolism

  • Source: European journal of medicinal chemistry [Eur J Med Chem] 2013 Apr; Vol. 62, pp. 379-94. Date of Electronic Publication: 2013 Jan 11.Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic

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  • 1-9 of  9 results for ""ADAMTS5 Protein""