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Academic Journal

The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response.

  • Authors : Liu X; National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Navy Medical University, Shanghai 200433, China; Department of Respiratory Disease, Affiliated Xihu Hospital, Hangzhou Medical College, Hangzhou 310013, China.

Subjects: Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/metabolism ; Immunity, Innate* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114608. Date of Electronic Publication: 2024 Aug 08.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited

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Academic Journal

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.

  • Authors : Kelly G; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.; Kataura T

Subjects: Mitophagy*/Mitophagy*/Mitophagy*/drug effects ; Cellular Senescence*/Cellular Senescence*/Cellular Senescence*/drug effects ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism

  • Source: Developmental cell [Dev Cell] 2024 Aug 05; Vol. 59 (15), pp. 1924-1939.e7. Date of Electronic Publication: 2024 Jun 18.Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited

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Academic Journal

The rice E3 ubiquitin ligase-transcription factor module targets two trypsin inhibitors to enhance broad-spectrum disease resistance.

  • Authors : Zhang C; State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.; Fang H

Subjects: Oryza*/Oryza*/Oryza*/microbiology ; Oryza*/Oryza*/Oryza*/metabolism ; Oryza*/Oryza*/Oryza*/genetics Xanthomonas oryzae

  • Source: Developmental cell [Dev Cell] 2024 Aug 05; Vol. 59 (15), pp. 2017-2033.e5. Date of Electronic Publication: 2024 May 22.Publisher: Cell Press Country of Publication: United States NLM ID: 101120028 Publication Model: Print-Electronic Cited

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Academic Journal

DOT1L/H3K79me2 represses HIV-1 reactivation via recruiting DCAF1.

  • Authors : Liang F; RNA Institute, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan 430072, China.; Jin J

Subjects: HIV-1*/HIV-1*/HIV-1*/physiology ; HIV-1*/HIV-1*/HIV-1*/metabolism ; Histone-Lysine N-Methyltransferase*/Histone-Lysine N-Methyltransferase*/Histone-Lysine N-Methyltransferase*/metabolism

  • Source: Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114368. Date of Electronic Publication: 2024 Jun 20.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited

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Academic Journal

UBR7 in concert with EZH2 inhibits the TGF-β signaling leading to extracellular matrix remodeling.

  • Authors : Adhikari S; Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064, India; Homi Bhabha National Institute, Mumbai, India.

Subjects: Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/Enhancer of Zeste Homolog 2 Protein*/metabolism ; Extracellular Matrix*/Extracellular Matrix*/Extracellular Matrix*/metabolism ; Signal Transduction*

  • Source: Cell reports [Cell Rep] 2024 Jul 23; Vol. 43 (7), pp. 114394. Date of Electronic Publication: 2024 Jun 25.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited

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Academic Journal

CBLs downregulation foretells T cell ubiquitination leading to autoimmunity.

  • Authors : Vidyarthi A; Yale University School of Medicine, New Haven, CT 06520-8031, USA.; Craft J

Subjects: Ubiquitination* ; Proto-Oncogene Proteins c-cbl*/Proto-Oncogene Proteins c-cbl*/Proto-Oncogene Proteins c-cbl*/metabolism ; Autoimmunity*

  • Source: Cell chemical biology [Cell Chem Biol] 2024 Jul 18; Vol. 31 (7), pp. 1239-1241.Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium:

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Academic Journal

C646 degrades Exportin-1 to modulate p300 chromatin occupancy and function.

  • Authors : Chen YF; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Chemical Biology Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

Subjects: Chromatin*/Chromatin*/Chromatin*/metabolism ; E1A-Associated p300 Protein*/E1A-Associated p300 Protein*/E1A-Associated p300 Protein*/metabolism ; Exportin 1 Protein*

  • Source: Cell chemical biology [Cell Chem Biol] 2024 Jul 18; Vol. 31 (7), pp. 1363-1372.e8. Date of Electronic Publication: 2024 Jun 24.Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited

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Academic Journal

Repurposing AS1411 for constructing ANM-PROTACs.

Subjects: *UBIQUITIN ligases; *TRANSCRIPTION factors; *LIGANDS (Biochemistry)

  • Source: Cell Chemical Biology. Jul2024, Vol. 31 Issue 7, p1290-1290. 1p.

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Academic Journal

MSL2 variants lead to a neurodevelopmental syndrome with lack of coordination, epilepsy, specific dysmorphisms, and a distinct episignature.

  • Authors : Karayol R; Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.; Borroto MC

Subjects: Epilepsy*/Epilepsy*/Epilepsy*/genetics ; Neurodevelopmental Disorders*/Neurodevelopmental Disorders*/Neurodevelopmental Disorders*/genetics ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: American journal of human genetics [Am J Hum Genet] 2024 Jul 11; Vol. 111 (7), pp. 1330-1351. Date of Electronic Publication: 2024 May 29.Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.

Subjects: *TYPE I interferons; *INTERFERON regulatory factors; *PROTEIN domains

  • Source: Molecular Cell. Jul2024, Vol. 84 Issue 13, p2436-2436. 1p.

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  • 1-10 of  1,431 results for ""UBIQUITIN ligases""