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Academic Journal

The picky mTORC1 in metabolic enzyme degradation.

Authors : Chun, Yujin¹ (AUTHOR); Fruman, David A.^2,3 (AUTHOR); Lee, Gina^1,3 (AUTHOR)

Subjects: *ENZYMES; *UBIQUITIN ligases

Source: Molecular Cell. Jun2024, Vol. 84 Issue 11, p2011-2013. 3p.

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Academic Journal

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

Authors : Zhang, Zhiqian (AUTHOR); Sie, Brandon (AUTHOR); Chang, Aiquan (AUTHOR)

Subjects: *UBIQUITIN ligases

Source: Molecular Cell. Nov2023, Vol. 83 Issue 22, p4191-4192. 2p.

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Academic Journal

Cryo-EM reveals important regulatory mechanism of the workhorses of targeted protein degradation.

Authors : Hjerpe, Roland¹ (AUTHOR); Kurz, Thimo^1,2,3 (AUTHOR)

Subjects: *PROTEOLYSIS; *UBIQUITIN ligases; *UBIQUITIN

Source: Molecular Cell. Jul2023, Vol. 83 Issue 13, p2159-2160. 2p.

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Academic Journal

Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.

Authors : Li, Xin^1,2,3 (AUTHOR) ; Sun, Weili^1,2,3 (AUTHOR); Huang, Mengxing¹ (AUTHOR)

Subjects: *T helper cells; *UBIQUITIN ligases; *T cells

Source: Immunity (10747613). Jul2024, Vol. 57 Issue 7, p1603-1603. 1p.

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Academic Journal

Lactate fuels mitosis.

Authors : Dai, Xiaoming¹ (AUTHOR) ; Wei, Wenyi¹ (AUTHOR)

Subjects: *UBIQUITIN ligases; *LACTATES; *LACTATION

Source: Molecular Cell. May2023, Vol. 83 Issue 10, p1549-1551. 3p.

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Academic Journal

Repurposing AS1411 for constructing ANM-PROTACs.

Authors : Fu, Xuekun^1,2 (AUTHOR); Li, Jin¹ (AUTHOR); Chen, Xinxin¹ (AUTHOR)

Subjects: *UBIQUITIN ligases; *TRANSCRIPTION factors; *LIGANDS (Biochemistry)

Source: Cell Chemical Biology. Jul2024, Vol. 31 Issue 7, p1290-1290. 1p.

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Academic Journal

Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.

Authors : Kschonsak, Yvonne T.¹ (AUTHOR) ; Gao, Xinxin^1,2 (AUTHOR) ; Miller, Stephen E.² (AUTHOR)

Subjects: *WNT signal transduction; *UBIQUITIN ligases; *INTESTINES

Source: Cell Chemical Biology. Jun2024, Vol. 31 Issue 6, p1176-1176. 1p.

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Academic Journal

The cyclimids: Degron-inspired cereblon binders for targeted protein degradation.

Authors : Ichikawa, Saki¹ (AUTHOR); Payne, N. Connor^1,2 (AUTHOR); Xu, Wenqing¹ (AUTHOR)

Subjects: *PROTEOLYSIS; *UBIQUITIN ligases; *LIGANDS (Biochemistry)

Source: Cell Chemical Biology. Jun2024, Vol. 31 Issue 6, p1162-1162. 1p.

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Academic Journal

Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.

Authors : Gottemukkala, Karthik V.^1,2 (AUTHOR); Chrustowicz, Jakub¹ (AUTHOR); Sherpa, Dawafuti¹ (AUTHOR)

Subjects: *UBIQUITIN ligases; *BIOTRANSFORMATION (Metabolism); *METABOLISM

Source: Molecular Cell. May2024, Vol. 84 Issue 10, p1948-1948. 1p.

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Academic Journal

Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.

Authors : Li, Jerry¹ (AUTHOR); Purser, Nicholas¹ (AUTHOR); Liwocha, Joanna^1,2 (AUTHOR)

Subjects: *LIGASES; *UBIQUITIN ligases; *UBIQUITIN-conjugating enzymes

Source: Molecular Cell. Apr2024, Vol. 84 Issue 7, p1304-1304. 1p.

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