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Academic Journal

The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome.

  • Authors : Stanton C; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Subjects: Pyruvaldehyde*/Pyruvaldehyde*/Pyruvaldehyde*/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism ; Inflammasomes*/Inflammasomes*/Inflammasomes*/metabolism

  • Source: Cell reports [Cell Rep] 2024 Sep 24; Vol. 43 (9), pp. 114688. Date of Electronic Publication: 2024 Aug 27.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited

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A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2.

  • Authors : Kong LR; Cancer Science Institute of Singapore, Singapore 117599, Singapore; NUS Centre for Cancer Research (N2CR), National University of Singapore, Singapore 117599, Singapore

Subjects: BRCA2 Protein*/BRCA2 Protein*/BRCA2 Protein*/metabolism ; BRCA2 Protein*/BRCA2 Protein*/BRCA2 Protein*/genetics ; Glycolysis*

  • Source: Cell [Cell] 2024 Apr 25; Vol. 187 (9), pp. 2269-2287.e16. Date of Electronic Publication: 2024 Apr 11.Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium:

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Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1.

  • Authors : Jun YW; Department of Chemistry, ChEM-H Institute, and Stanford Cancer Institute, Stanford University, Stanford, CA 94305, USA.; Kool ET

Subjects: Glycation End Products, Advanced/Glycation End Products, Advanced/Glycation End Products, Advanced/*metabolism ; Protein Deglycase DJ-1/Protein Deglycase DJ-1/Protein Deglycase DJ-1/*metabolism ; Pyruvaldehyde/Pyruvaldehyde/Pyruvaldehyde/*metabolism

  • Source: Cell chemical biology [Cell Chem Biol] 2020 Sep 17; Vol. 27 (9), pp. 1117-1123. Date of Electronic Publication: 2020 Aug 11.Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited

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Academic Journal

Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis.

  • Authors : Salomón T; Department of Forensic Medicine, Aarhus University, Aarhus 8200, Denmark.; Sibbersen C

Subjects: Acetoacetates/Acetoacetates/Acetoacetates/*chemistry ; Ketone Bodies/Ketone Bodies/Ketone Bodies/*chemistry ; Pyruvaldehyde/Pyruvaldehyde/Pyruvaldehyde/*blood

  • Source: Cell chemical biology [Cell Chem Biol] 2017 Aug 17; Vol. 24 (8), pp. 935-943.e7.Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium:

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Academic Journal

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab.

  • Authors : Bellier J; Metastasis Research Laboratory, GIGA-Cancer, University of Liège, Liège, Belgium.; Nokin MJ

Subjects: Cetuximab/Cetuximab/Cetuximab/*therapeutic use ; Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*drug therapy ; Free Radical Scavengers/Free Radical Scavengers/Free Radical Scavengers/*pharmacology

  • Source: Cell reports [Cell Rep] 2020 Feb 04; Vol. 30 (5), pp. 1400-1416.e6.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium:

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Academic Journal

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.

  • Authors : Moraru A; German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Heidelberg University, 69120 Heidelberg, Germany.

Subjects: Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/Diabetes Mellitus, Type 2/*metabolism ; Pyruvaldehyde/Pyruvaldehyde/Pyruvaldehyde/*metabolism; Animals

  • Source: Cell metabolism [Cell Metab] 2018 Apr 03; Vol. 27 (4), pp. 926-934.e8. Date of Electronic Publication: 2018 Mar 15.Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited

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Academic Journal

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis.

  • Authors : Ravichandran M; Energy Metabolism Laboratory, Institute of Translational Medicine, D-HEST, Swiss Federal Institute of Technology (ETH) Zürich, Schwerzenbach 8603, Switzerland; Life Sciences Zürich Graduate School, Molecular and Translational Biomedicine Program, Zurich 8044, Switzerland.

Subjects: Acetyltransferases/Acetyltransferases/Acetyltransferases/*physiology ; Caenorhabditis elegans/Caenorhabditis elegans/Caenorhabditis elegans/*metabolism ; Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/Caenorhabditis elegans Proteins/*metabolism

  • Source: Cell metabolism [Cell Metab] 2018 Apr 03; Vol. 27 (4), pp. 914-925.e5. Date of Electronic Publication: 2018 Mar 15.Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited

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Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcription.

  • Authors : Yao D; JDRF International Center for Diabetic Complications Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA.; Taguchi T

Subjects: Angiopoietin-2/Angiopoietin-2/Angiopoietin-2/*metabolism ; Glycolysis/Glycolysis/Glycolysis/*physiology ; Pyruvaldehyde/Pyruvaldehyde/Pyruvaldehyde/*metabolism

  • Source: Cell [Cell] 2006 Jan 27; Vol. 124 (2), pp. 275-86. Date of Electronic Publication: 2006 Jan 12.Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Methylglyoxal comes of AGE.

  • Authors : Ramasamy R; Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA.; Yan SF

Subjects: Gene Expression Regulation/Gene Expression Regulation/Gene Expression Regulation/*physiology ; Glycation End Products, Advanced/Glycation End Products, Advanced/Glycation End Products, Advanced/*biosynthesis ; Pyruvaldehyde/Pyruvaldehyde/Pyruvaldehyde/*metabolism

  • Source: Cell [Cell] 2006 Jan 27; Vol. 124 (2), pp. 258-60.Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Print

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A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification.

  • Authors : Chaudhuri J; The Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.; Bose N

Subjects: Aging* ; Signal Transduction*; Caenorhabditis elegans/Caenorhabditis elegans/Caenorhabditis elegans/*physiology

  • Source: Current biology : CB [Curr Biol] 2016 Nov 21; Vol. 26 (22), pp. 3014-3025. Date of Electronic Publication: 2016 Oct 20.Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  18 results for ""PYRUVALDEHYDE""