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Academic Journal

TRIM65 regulates innate immune signaling by enhancing K6-linked ubiquitination of IRF3 and its chromatin recruitment.

  • Authors : Fonseca D; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Subjects: Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/metabolism ; Immunity, Innate* ; Ubiquitination*

  • Source: Cell reports [Cell Rep] 2024 Dec 24; Vol. 43 (12), pp. 114960. Date of Electronic Publication: 2024 Nov 23.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited

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Academic Journal

Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity.

  • Authors : Bu L; Center of Lung Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510275, China; Institute of Precision Medicine, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510275, China. Electronic address: .

Subjects: Immunity, Innate*/Immunity, Innate*/Immunity, Innate*/drug effects ; Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/genetics ; Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/Adaptor Proteins, Signal Transducing*/metabolism

  • Source: Molecular cell [Mol Cell] 2024 Sep 19; Vol. 84 (18), pp. 3513-3529.e5. Date of Electronic Publication: 2024 Sep 09.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1.

  • Authors : Luo G; Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China.; Zhang J

Subjects: Candida albicans*/Candida albicans*/Candida albicans*/immunology ; Candida albicans*/Candida albicans*/Candida albicans*/pathogenicity ; Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/metabolism

  • Source: Cell host & microbe [Cell Host Microbe] 2024 Sep 11; Vol. 32 (9), pp. 1536-1551.e6. Date of Electronic Publication: 2024 Jul 30.Publisher: Cell Press Country of Publication: United States NLM ID: 101302316 Publication Model: Print-Electronic Cited

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Academic Journal

The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response.

  • Authors : Liu X; National Key Laboratory of Immunity and Inflammation, Institute of Immunology, Navy Medical University, Shanghai 200433, China; Department of Respiratory Disease, Affiliated Xihu Hospital, Hangzhou Medical College, Hangzhou 310013, China.

Subjects: Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/metabolism ; Immunity, Innate* ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism

  • Source: Cell reports [Cell Rep] 2024 Aug 27; Vol. 43 (8), pp. 114608. Date of Electronic Publication: 2024 Aug 08.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited

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Academic Journal

pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism.

  • Authors : Landau LM; Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.; Chaudhary N

Subjects: Signal Transduction* ; Interferons*/Interferons*/Interferons*/metabolism ; Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/metabolism

  • Source: Molecular cell [Mol Cell] 2024 Jul 11; Vol. 84 (13), pp. 2436-2454.e10. Date of Electronic Publication: 2024 Jun 25.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

PELI2 is a negative regulator of STING signaling that is dynamically repressed during viral infection.

  • Authors : Ritchie C; Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Sarafan ChEM-H Institute, Stanford University, Stanford, CA 94305, USA

Subjects: Signal Transduction* ; Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/metabolism ; Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/Protein Serine-Threonine Kinases*/genetics

  • Source: Molecular cell [Mol Cell] 2024 Jul 11; Vol. 84 (13), pp. 2423-2435.e5. Date of Electronic Publication: 2024 Jun 24.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response.

  • Authors : Yang S; Guangdong Province Key Laboratory of Pharmaceutical Functional Genes, MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China.; Jin S

Subjects: Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/genetics ; Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/Interferon Regulatory Factor-3*/metabolism ; Interferon Type I*/Interferon Type I*/Interferon Type I*/genetics

  • Source: Molecular cell [Mol Cell] 2023 Jan 19; Vol. 83 (2), pp. 298-313.e8. Date of Electronic Publication: 2023 Jan 04.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

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Academic Journal

IRF3-binding lncRNA-ISIR strengthens interferon production in viral infection and autoinflammation.

  • Authors : Xu J; Department of Immunology, Center for Immunotherapy, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China.

Subjects: Interferon Regulatory Factor-3/Interferon Regulatory Factor-3/Interferon Regulatory Factor-3/*metabolism ; Lupus Erythematosus, Systemic/Lupus Erythematosus, Systemic/Lupus Erythematosus, Systemic/*metabolism ; Macrophages, Peritoneal/Macrophages, Peritoneal/Macrophages, Peritoneal/*metabolism

  • Source: Cell reports [Cell Rep] 2021 Nov 02; Vol. 37 (5), pp. 109926.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium:

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Academic Journal

Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.

  • Authors : de Oliveira Mann CC; Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Subjects: Immunity, Innate/Immunity, Innate/Immunity, Innate/*immunology ; Interferon Regulatory Factor-3/Interferon Regulatory Factor-3/Interferon Regulatory Factor-3/*metabolism ; Interferon Type I/Interferon Type I/Interferon Type I/*metabolism

  • Source: Cell reports [Cell Rep] 2019 Apr 23; Vol. 27 (4), pp. 1165-1175.e5.Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium:

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Academic Journal

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.

  • Authors : Ning X; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, School of Life Sciences, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Beijing 100871, China.

Subjects: Apoptosis*; Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Caspases/Caspases/Caspases/*metabolism

  • Source: Molecular cell [Mol Cell] 2019 Apr 04; Vol. 74 (1), pp. 19-31.e7. Date of Electronic Publication: 2019 Mar 13.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

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  • 1-10 of  116 results for ""Interferon Regulatory Factor-3""