Search Results

E2A, VA RNA I, and L4-22k adenoviral helper genes are sufficient for AAV production in HEK293 cells.

• Authors : Doshi J; Schepens Eye Research Institute, Mass Eye and Ear Infirmary, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.

• Source: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2024 Nov 13; Vol. 32 (4), pp. 101376. Date of Electronic Publication: 2024 Nov 13 (Print Publisher: Cell Press Country of Publication: United States NLM ID: 101624857 Publication Model: eCollection Cited Medium:

Record details

Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells.

• Authors : Liu S; Avirmax Biopharma Inc., Hayward, CA 94545, USA. Electronic address: .; Li J

Subjects: Genetic Vectors*/Genetic Vectors*/Genetic Vectors*/genetics ; Kidney*; Animals

• Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2024 Jan 03; Vol. 32 (1), pp. 74-83. Date of Electronic Publication: 2023 Nov 20.Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited

Record details

Cell-cycle-dependent mRNA localization in P-bodies.

• Authors : Safieddine, Adham¹ (AUTHOR) ; Benassy, Marie-Noëlle¹ (AUTHOR); Bonte, Thomas^2,3,4 (AUTHOR)

Subjects: *GENE expression; *FLUORESCENCE in situ hybridization; *CELL cycle

• Source: Molecular Cell. Nov2024, Vol. 84 Issue 21, p4191-42420. 38230p.

Record details

Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders.

• Authors : Lu P; Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China; National Institute of Biological Sciences, Beijing 102206, China.

Subjects: Proteolysis*/Proteolysis*/Proteolysis*/drug effects ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ribonucleoproteins*/Ribonucleoproteins*/Ribonucleoproteins*/metabolism

• Source: Cell [Cell] 2024 Dec 12; Vol. 187 (25), pp. 7126-7142.e20. Date of Electronic Publication: 2024 Nov 01.Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium:

Record details

Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch.

• Authors : Yang J; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

Subjects: Bile Acids and Salts*/Bile Acids and Salts*/Bile Acids and Salts*/metabolism ; Bile Acids and Salts*/Bile Acids and Salts*/Bile Acids and Salts*/chemistry ; Pruritus*/Pruritus*/Pruritus*/drug therapy

• Source: Cell [Cell] 2024 Dec 12; Vol. 187 (25), pp. 7164-7182.e18. Date of Electronic Publication: 2024 Oct 29.Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium:

Record details

Reactive oxygen species control protein degradation at the mitochondrial import gate.

• Authors : McMinimy R; Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720, USA.; Manford AG

Subjects: Reactive Oxygen Species*/Reactive Oxygen Species*/Reactive Oxygen Species*/metabolism ; Mitochondria*/Mitochondria*/Mitochondria*/metabolism ; Proteolysis*

• Source: Molecular cell [Mol Cell] 2024 Dec 05; Vol. 84 (23), pp. 4612-4628.e13.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium:

Record details

m6A sites in the coding region trigger translation-dependent mRNA decay.

• Authors : Zhou Y; Buchmann Institute for Molecular Life Sciences (BMLS) & Institute of Molecular Biosciences, Goethe University Frankfurt, 60438 Frankfurt a.M., Germany; Theodor Boveri Institute, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.

Subjects: Adenosine*/Adenosine*/Adenosine*/analogs & derivatives ; Adenosine*/Adenosine*/Adenosine*/metabolism ; Adenosine*/Adenosine*/Adenosine*/genetics

• Source: Molecular cell [Mol Cell] 2024 Dec 05; Vol. 84 (23), pp. 4576-4593.e12. Date of Electronic Publication: 2024 Nov 21.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

Record details

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance.

• Authors : Chen Z; Rudolf Virchow Zentrum (RVZ), Center for Integrative and Translational Bioimaging, University of Wuerzburg, 97080 Wuerzburg, Germany.; Inague A

Subjects: Ferroptosis*/Ferroptosis*/Ferroptosis*/genetics ; Selenocysteine*/Selenocysteine*/Selenocysteine*/metabolism ; Selenocysteine*/Selenocysteine*/Selenocysteine*/genetics

• Source: Molecular cell [Mol Cell] 2024 Dec 05; Vol. 84 (23), pp. 4645-4659.e9. Date of Electronic Publication: 2024 Nov 14.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

Record details

ARF alters PAF1 complex integrity to selectively repress oncogenic transcription programs upon p53 loss.

• Authors : Wang J; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.; Fendler NL

Subjects: Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/metabolism ; Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/Tumor Suppressor Protein p53*/genetics ; Transcription, Genetic*

• Source: Molecular cell [Mol Cell] 2024 Dec 05; Vol. 84 (23), pp. 4538-4557.e12. Date of Electronic Publication: 2024 Nov 11.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

Record details

Profound synthetic lethality between SMARCAL1 and FANCM.

• Authors : Feng S; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada.; Liu K

Subjects: DNA Helicases*/DNA Helicases*/DNA Helicases*/genetics ; DNA Helicases*/DNA Helicases*/DNA Helicases*/metabolism ; Synthetic Lethal Mutations*/Synthetic Lethal Mutations*/Synthetic Lethal Mutations*/genetics

• Source: Molecular cell [Mol Cell] 2024 Dec 05; Vol. 84 (23), pp. 4522-4537.e7. Date of Electronic Publication: 2024 Nov 06.Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium:

Record details