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Academic Journal

Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson's model.

  • Authors : Weiss F; School of Medical Sciences, Faculty of Medicine and Health and the Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia.; Hughes L

Subjects: Toll-Like Receptor 2*/Toll-Like Receptor 2*/Toll-Like Receptor 2*/metabolism ; Toll-Like Receptor 2*/Toll-Like Receptor 2*/Toll-Like Receptor 2*/genetics ; Astrocytes*/Astrocytes*/Astrocytes*/metabolism

  • Source: Translational neurodegeneration [Transl Neurodegener] 2024 Dec 16; Vol. 13 (1), pp. 62. Date of Electronic Publication: 2024 Dec 16.Publisher: BioMed Central Country of Publication: England NLM ID: 101591861 Publication Model: Electronic Cited Medium:

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Academic Journal

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

  • Authors : Jones-Tabah J; Neurodegenerative Diseases Group, Department of Neurology and Neurosurgery, McGill Parkinson Program, Montreal Neurological Institute-Hospital, McGill University, Montreal, Québec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montréal, Canada.

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Nov 25; Vol. 19 (1), pp. 88. Date of Electronic Publication: 2024 Nov 25.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium:

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Academic Journal

BCKDK loss impairs mitochondrial Complex I activity and drives alpha-synuclein aggregation in models of Parkinson's disease.

  • Authors : Jishi A; Department of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.; Hu D

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Electron Transport Complex I*/Electron Transport Complex I*/Electron Transport Complex I*/metabolism ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/metabolism

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Dec 21; Vol. 12 (1), pp. 198. Date of Electronic Publication: 2024 Dec 21.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium:

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Academic Journal

Autoantibody profiles in Alzheimer´s, Parkinson´s, and dementia with Lewy bodies: altered IgG affinity and IgG/IgM/IgA responses to alpha-synuclein, amyloid-beta, and tau in disease-specific pathological patterns.

  • Authors : Knecht L; Centre for Neuroscience and Stereology, Department of Neurology, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Nielsine Nielsens Vej 6B, Entrance 11B, 2. floor, Copenhagen, NV, DK-2400, Denmark.; Copenhagen Center for Translational Research, Bispebjerg and Frederiksberg Hospital, Copenhagen University Hospital, Nielsine Nielsens Vej 4B, Copenhagen, NV, DK-2400, Denmark.

Subjects: tau Proteins*/tau Proteins*/tau Proteins*/immunology ; tau Proteins*/tau Proteins*/tau Proteins*/metabolism ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/immunology

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2024 Dec 03; Vol. 21 (1), pp. 317. Date of Electronic Publication: 2024 Dec 03.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium:

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Academic Journal

Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy.

  • Authors : Joers V; Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, USA. .; Center for Translational Research in Neurodegenerative Disease, University of Florida College of Medicine, Gainesville, FL, USA. .

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Receptor, Cannabinoid, CB2*/Receptor, Cannabinoid, CB2*/Receptor, Cannabinoid, CB2*/metabolism ; Substantia Nigra*/Substantia Nigra*/Substantia Nigra*/metabolism

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2024 Sep 27; Vol. 21 (1), pp. 240. Date of Electronic Publication: 2024 Sep 27.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium:

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Academic Journal

Alpha-synuclein-induced stress sensitivity renders the Parkinson's disease brain susceptible to neurodegeneration.

  • Authors : Nakos Bimpos M; Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens - BRFAA, 11527, Athens, Greece.; Karali K

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics ; Parkinson Disease*/Parkinson Disease*/Parkinson Disease*/metabolism

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 Jun 17; Vol. 12 (1), pp. 100. Date of Electronic Publication: 2024 Jun 17.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium:

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Academic Journal

Alpha-synuclein aggregates are phosphatase resistant.

  • Authors : Choi SG; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Tittle T

Subjects: alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism ; Brain*/Brain*/Brain*/metabolism ; Brain*/Brain*/Brain*/pathology

  • Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2024 May 31; Vol. 12 (1), pp. 84. Date of Electronic Publication: 2024 May 31.Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium:

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Academic Journal

Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.

  • Authors : Stoll AC; Department of Translational Neuroscience, Michigan State University, 400 Monroe Ave NW, Grand Rapids, MI, 49503, USA.; Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, USA.

Subjects: Microglia*/Microglia*/Microglia*/metabolism ; Microglia*/Microglia*/Microglia*/drug effects ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism

  • Source: Journal of neuroinflammation [J Neuroinflammation] 2024 Apr 25; Vol. 21 (1), pp. 108. Date of Electronic Publication: 2024 Apr 25.Publisher: BioMed Central Country of Publication: England NLM ID: 101222974 Publication Model: Electronic Cited Medium:

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Academic Journal

Dementia with lewy bodies patients with high tau levels display unique proteome profiles.

  • Authors : Greally S; F.M. Kirby Neurobiology Center, Department of Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.; Kumar M

Subjects: Lewy Body Disease*/Lewy Body Disease*/Lewy Body Disease*/metabolism ; Lewy Body Disease*/Lewy Body Disease*/Lewy Body Disease*/pathology ; tau Proteins*/tau Proteins*/tau Proteins*/metabolism

  • Source: Molecular neurodegeneration [Mol Neurodegener] 2024 Dec 19; Vol. 19 (1), pp. 98. Date of Electronic Publication: 2024 Dec 19.Publisher: BioMed Central Country of Publication: England NLM ID: 101266600 Publication Model: Electronic Cited Medium:

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Academic Journal

Investigation in the cannabigerol derivative VCE-003.2 as a disease-modifying agent in a mouse model of experimental synucleinopathy.

  • Authors : Burgaz S; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, Madrid, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.

Subjects: Disease Models, Animal* ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/genetics ; alpha-Synuclein*/alpha-Synuclein*/alpha-Synuclein*/metabolism

  • Source: Behavioral and brain functions : BBF [Behav Brain Funct] 2024 Nov 01; Vol. 20 (1), pp. 28. Date of Electronic Publication: 2024 Nov 01.Publisher: BioMed Central Country of Publication: England NLM ID: 101245751 Publication Model: Electronic Cited Medium:

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  • 1-10 of  3,401 results for ""alpha-Synuclein""