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Academic Journal

Actin fence therapy with exogenous V12Rac1 protects against acute lung injury.

  • Authors : Gusarova GA; Lung Biology Laboratory, Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine.; Das SR

Subjects: Actins/Actins/Actins/*therapeutic use ; Acute Lung Injury/Acute Lung Injury/Acute Lung Injury/*prevention & control ; Neuropeptides/Neuropeptides/Neuropeptides/*therapeutic use

  • Source: JCI insight [JCI Insight] 2021 Mar 22; Vol. 6 (6). Date of Electronic Publication: 2021 Mar 22.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

RASAL2 activates RAC1 to promote triple-negative breast cancer progression.

Subjects: Signal Transduction*; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*metabolism ; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2014 Dec; Vol. 124 (12), pp. 5291-304. Date of Electronic Publication: 2014 Nov 10.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1.

  • Authors : Sussman MA; The Children's Hospital and Research Foundation, Division of Molecular Cardiovascular Biology, Cincinnati, Ohio 45229, USA. ; Welch S

Subjects: Cell Adhesion*; Cardiomyopathy, Dilated/Cardiomyopathy, Dilated/Cardiomyopathy, Dilated/*metabolism ; rac1 GTP-Binding Protein/rac1 GTP-Binding Protein/rac1 GTP-Binding Protein/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2000 Apr; Vol. 105 (7), pp. 875-86.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

RAC1 activation drives pathologic interactions between the epidermis and immune cells.

Subjects: Epidermis/Epidermis/Epidermis/*metabolism ; Keratinocytes/Keratinocytes/Keratinocytes/*cytology ; Psoriasis/Psoriasis/Psoriasis/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2016 Jul 01; Vol. 126 (7), pp. 2661-77. Date of Electronic Publication: 2016 Jun 13.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1.

Subjects: Oxidative Stress*; Acute Kidney Injury/Acute Kidney Injury/Acute Kidney Injury/*enzymology ; Ischemia/Ischemia/Ischemia/*enzymology

  • Source: The Journal of clinical investigation [J Clin Invest] 2014 Nov; Vol. 124 (11), pp. 4989-5001. Date of Electronic Publication: 2014 Oct 08.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Activation of Rac1 by Src-dependent phosphorylation of Dock180(Y1811) mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans.

  • Authors : Feng H; Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.; Hu B

Subjects: Protein Processing, Post-Translational*; Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*metabolism ; Glioblastoma/Glioblastoma/Glioblastoma/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2011 Dec; Vol. 121 (12), pp. 4670-84. Date of Electronic Publication: 2011 Nov 14.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.

  • Authors : Shibata S; Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.; Mu S

Subjects: Kidney/Kidney/Kidney/*metabolism ; rac1 GTP-Binding Protein/rac1 GTP-Binding Protein/rac1 GTP-Binding Protein/*metabolism; Aldosterone/Aldosterone/Aldosterone/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2011 Aug; Vol. 121 (8), pp. 3233-43. Date of Electronic Publication: 2011 Jul 18.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes.

  • Authors : Tiede I; Laboratory of Immunology, Department of Medicine, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany.; Fritz G

Subjects: Azathioprine/Azathioprine/Azathioprine/*pharmacology ; CD28 Antigens/CD28 Antigens/CD28 Antigens/*physiology ; CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/CD4-Positive T-Lymphocytes/*drug effects

  • Source: The Journal of clinical investigation [J Clin Invest] 2003 Apr; Vol. 111 (8), pp. 1133-45.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Critical role of thrombospondin-1 in promoting intestinal mucosal wound repair.

Subjects: Thrombospondin 1*/Thrombospondin 1*/Thrombospondin 1*/metabolism ; Thrombospondin 1*/Thrombospondin 1*/Thrombospondin 1*/genetics ; Wound Healing*/Wound Healing*/Wound Healing*/physiology

  • Source: JCI insight [JCI Insight] 2024 Jul 30; Vol. 9 (17). Date of Electronic Publication: 2024 Jul 30.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Increased flux through the mevalonate pathway mediates fibrotic repair without injury.

  • Authors : Larson-Casey JL; Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, and.; Vaid M

Subjects: Idiopathic Pulmonary Fibrosis/Idiopathic Pulmonary Fibrosis/Idiopathic Pulmonary Fibrosis/*metabolism ; Macrophages/Macrophages/Macrophages/*metabolism ; Mevalonic Acid/Mevalonic Acid/Mevalonic Acid/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2019 Nov 01; Vol. 129 (11), pp. 4962-4978.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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