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Publisher : american society for clinical investigation

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Academic Journal

HIF-2α expression and metabolic signaling require ACSS2 in clear cell renal cell carcinoma.

Authors : Bacigalupa, Zachary A.; Arner, Emily N.; Vlach, Logan M.

Subjects: RENAL cell carcinoma; PROTEOLYSIS; UBIQUITIN ligases

Source: Journal of Clinical Investigation. 6/17/2024, Vol. 134 Issue 12, p1-19. 19p.

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Academic Journal

RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.

Authors : Patel, Parasvi S.¹; Abraham, Karan Joshua²; Naidu Guturi, Kiran Kumar¹

Subjects: *UBIQUITIN ligases; *DOUBLE-strand DNA breaks; *GENES

Source: Journal of Clinical Investigation. 2/1/2021, Vol. 131 Issue 3, p1-14. 14p.

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Academic Journal

Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.

Authors : Louis-Dit-Picard, Hélène¹; Kouranti, Ilektra¹; Rafael, Chloé^1,2,3

Subjects: *UBIQUITIN ligases; *ION transport (Biology); *GENETIC disorders

Source: Journal of Clinical Investigation. Dec2020, Vol. 130 Issue 12, p6379-6394. 16p.

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Academic Journal

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.

Authors : Juan Liu¹; Cen Zhang¹; Hao Wu¹

Subjects: *UBIQUITIN ligases; *CANCER invasiveness; *PHOSPHONATES

Source: Journal of Clinical Investigation. Jun2020, Vol. 130 Issue 6, p3253-3269. 17p. 1 Color Photograph, 1 Diagram, 2 Charts, 6 Graphs.

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Academic Journal

Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth.

Authors : Youchao Dai; Chuanzhi Zhu; Wei Xiao

Subjects: MYCOBACTERIUM tuberculosis; IRON in the body; UBIQUITIN ligases

Source: Journal of Clinical Investigation. 4/17/2023, Vol. 133 Issue 8, p1-12. 12p.

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Academic Journal

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.

Authors : Li Li¹; Naidu Guturi, Kiran Kumar¹; Gautreau, Brandon¹

Subjects: *UBIQUITIN ligases; *NOTCH signaling pathway; *NEOPLASTIC cell transformation

Source: Journal of Clinical Investigation. Oct2018, Vol. 128 Issue 10, p4525-4542. 18p.

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Academic Journal

The UBE2C/CDH1/DEPTOR axis is an oncogene and tumor suppressor cascade in lung cancer cells.

Authors : Shizhen Zhang; Xiahong You; Yawen Zheng

Subjects: LUNG cancer; CANCER cells; UBIQUITIN-conjugating enzymes

Source: Journal of Clinical Investigation. 2/15/2023, Vol. 133 Issue 4, p1-14. 15p.

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Academic Journal

Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.

Authors : Ling Ding; Xi Chen; Wenxin Zhang

Subjects: CANAGLIFLOZIN; PROGRAMMED death-ligand 1; CYTOTOXIC T cells

Source: Journal of Clinical Investigation. 1/3/2023, Vol. 133 Issue 1, p1-19. 19p.

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Academic Journal

Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.

Authors : Knies, Kerstin¹; Shojiro Inano^2,3; Ramírez, María J.^4,5

Subjects: *FANCONI'S anemia; *UBIQUITIN ligases; *CELL cycle

Source: Journal of Clinical Investigation. Aug2017, Vol. 127 Issue 8, p3013-3027. 15p.

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Academic Journal

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer.

Authors : Signoretti, Sabina (AUTHOR); Di Marcotullio, Lucia (AUTHOR); Richardson, Andrea (AUTHOR)

Subjects: *UBIQUITIN ligases; *BREAST cancer

Source: Journal of Clinical Investigation. Nov2016, Vol. 126 Issue 11, p4387-4387. 1/3p.

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