Search Results

Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease.

• Authors : Sato AY; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Subjects: Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/metabolism ; Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/Ubiquitin-Protein Ligases*/genetics ; Glucocorticoids*/Glucocorticoids*/Glucocorticoids*/pharmacology

• Source: JCI insight [JCI Insight] 2024 Nov 08; Vol. 9 (21). Date of Electronic Publication: 2024 Nov 08.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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ADAM17 variant causes hair loss via ubiquitin ligase TRIM47-mediated degradation.

• Authors : Wang X; Department of Dermatology, Xinhua Hospital, and.; Institute of Dermatology, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Subjects: ADAM17 Protein*/ADAM17 Protein*/ADAM17 Protein*/metabolism ; ADAM17 Protein*/ADAM17 Protein*/ADAM17 Protein*/genetics ; Alopecia*/Alopecia*/Alopecia*/genetics

• Source: JCI insight [JCI Insight] 2024 May 21; Vol. 9 (13). Date of Electronic Publication: 2024 May 21.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Disassembly of the TRIM56-ATR complex promotes cytoDNA/cGAS/STING axis-dependent intervertebral disc inflammatory degeneration.

• Authors : Zhang W; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Li G

Subjects: Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/genetics ; Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/Intervertebral Disc Degeneration*/metabolism ; Nucleus Pulposus*/Nucleus Pulposus*/Nucleus Pulposus*/metabolism

• Source: The Journal of clinical investigation [J Clin Invest] 2024 Jan 23; Vol. 134 (6). Date of Electronic Publication: 2024 Jan 23.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.

• Authors : Deger SM; Division of Nephrology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.; CSRD&D, Veterans Administration Tennessee Valley Healthcare System, Nashville, Tennessee, USA.

Subjects: Inflammation* ; Renal Dialysis*; Muscle Proteins/Muscle Proteins/Muscle Proteins/*metabolism

• Source: JCI insight [JCI Insight] 2017 Nov 16; Vol. 2 (22). Date of Electronic Publication: 2017 Nov 16 (Print Publication: 2017).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components.

• Authors : Neagu MR; Department of Microbiology and Columbia University, New York, NY, USA.; Ziegler P

Subjects: Anti-HIV Agents/Anti-HIV Agents/Anti-HIV Agents/*metabolism ; Carrier Proteins/Carrier Proteins/Carrier Proteins/*metabolism ; Cyclophilin A/Cyclophilin A/Cyclophilin A/*metabolism

• Source: The Journal of clinical investigation [J Clin Invest] 2009 Oct; Vol. 119 (10), pp. 3035-47. Date of Electronic Publication: 2009 Sep 08.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Primitive hematopoietic cells resist HIV-1 infection via p21.

• Authors : Zhang J; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02114, USA.; Scadden DT

Subjects: Cyclin-Dependent Kinase Inhibitor p21/Cyclin-Dependent Kinase Inhibitor p21/Cyclin-Dependent Kinase Inhibitor p21/*physiology ; HIV Infections/HIV Infections/HIV Infections/*prevention & control ; HIV-1/HIV-1/HIV-1/*pathogenicity

• Source: The Journal of clinical investigation [J Clin Invest] 2007 Feb; Vol. 117 (2), pp. 473-81.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting.

• Authors : Song YH; Tulane University Health Sciences Center, New Orleans, Louisiana 70112-2699, USA.; Li Y

Subjects: Signal Transduction*/Signal Transduction*/Signal Transduction*/drug effects ; Signal Transduction*/Signal Transduction*/Signal Transduction*/genetics; Angiotensin II/Angiotensin II/Angiotensin II/*administration & dosage

• Source: The Journal of clinical investigation [J Clin Invest] 2005 Feb; Vol. 115 (2), pp. 451-8.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus.

• Authors : Billaut-Mulot O; Laboratory of Molecular Immunology of Infection and Inflammation, Institut Pasteur de Lille, Lille, France.; Cocude C

Subjects: RNA, Small Cytoplasmic*; Autoantibodies/Autoantibodies/Autoantibodies/*blood ; Autoantigens/Autoantigens/Autoantigens/*immunology

• Source: The Journal of clinical investigation [J Clin Invest] 2001 Sep; Vol. 108 (6), pp. 861-9.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys.

• Authors : Bosinger, Steven E.; Li, Qingsheng; Gordon, Shari N.

• Source: Journal of Clinical Investigation. December, 2009, Vol. 119 Issue 12, p3556, 17 p.

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