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Academic Journal

Transcriptomic profiling of thyroid eye disease orbital fat demonstrates differences in adipogenicity and IGF-1R pathway.

  • Authors : Kim DW; Danish Research Institute of Translational Neuroscience (DANDRITE), Nordic EMBL Partnership for Molecular Medicine, and.; Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Subjects: Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/metabolism ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/genetics ; Graves Ophthalmopathy*/Graves Ophthalmopathy*/Graves Ophthalmopathy*/pathology

  • Source: JCI insight [JCI Insight] 2024 Dec 20; Vol. 9 (24). Date of Electronic Publication: 2024 Dec 20.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy.

  • Authors : Song D; Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.; Department of Pharmacology, Chongqing Medical University, Chongqing, China.

Subjects: Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/genetics ; Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/metabolism ; Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/Insulin-Like Growth Factor II*/immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Nov 15; Vol. 134 (22). Date of Electronic Publication: 2024 Nov 15.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling.

  • Authors : Nagao H; Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.; Cai W

Subjects: Insulin*/Insulin*/Insulin*/metabolism ; Receptor, IGF Type 1*/Receptor, IGF Type 1*/Receptor, IGF Type 1*/genetics ; Receptor, IGF Type 1*/Receptor, IGF Type 1*/Receptor, IGF Type 1*/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2023 Feb 15; Vol. 133 (4). Date of Electronic Publication: 2023 Feb 15.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle.

  • Authors : Bhardwaj G; Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Veterans Affairs Health Care System, Iowa City, Iowa, USA.

Subjects: Electron Transport Complex I/Electron Transport Complex I/Electron Transport Complex I/*metabolism ; Forkhead Transcription Factors/Forkhead Transcription Factors/Forkhead Transcription Factors/*metabolism ; Muscle, Skeletal/Muscle, Skeletal/Muscle, Skeletal/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Sep 15; Vol. 131 (18).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

GIGYF1-disturbed IGF-1R recycling: a potential contributor to autism spectrum disorder pathogenesis?

  • Authors : Xing M; Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health and Affiliated Kangning Hospital, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University.; Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision and Brain Health, Wenzhou, Zhejiang, China.

Subjects: Autism Spectrum Disorder*/Autism Spectrum Disorder*/Autism Spectrum Disorder*/genetics; Receptor, IGF Type 1/Receptor, IGF Type 1/Receptor, IGF Type 1/*metabolism; Animals

  • Source: The Journal of clinical investigation [J Clin Invest] 2022 Oct 03; Vol. 132 (19). Date of Electronic Publication: 2022 Oct 03.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis.

Subjects: Mechanotransduction, Cellular/Mechanotransduction, Cellular/Mechanotransduction, Cellular/*physiology ; Myofibroblasts/Myofibroblasts/Myofibroblasts/*metabolism ; Pulmonary Alveoli/Pulmonary Alveoli/Pulmonary Alveoli/*cytology

  • Source: JCI insight [JCI Insight] 2021 Mar 22; Vol. 6 (6). Date of Electronic Publication: 2021 Mar 22.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells.

  • Authors : Scamuffa N; INSERM U716, Equipe Avenir, Institut de Génétique Moléculaire, and Université Paris 7, Paris, France.; Siegfried G

Subjects: Colorectal Neoplasms/Colorectal Neoplasms/Colorectal Neoplasms/*enzymology ; Liver Neoplasms/Liver Neoplasms/Liver Neoplasms/*enzymology ; Proprotein Convertases/Proprotein Convertases/Proprotein Convertases/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2008 Jan; Vol. 118 (1), pp. 352-63.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Knockout of insulin and IGF-1 receptors on vascular endothelial cells protects against retinal neovascularization.

  • Authors : Kondo T; Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.; Vicent D

Subjects: Neovascularization, Pathologic*; Diabetic Retinopathy/Diabetic Retinopathy/Diabetic Retinopathy/*prevention & control ; Receptor, IGF Type 1/Receptor, IGF Type 1/Receptor, IGF Type 1/*deficiency

  • Source: The Journal of clinical investigation [J Clin Invest] 2003 Jun; Vol. 111 (12), pp. 1835-42.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.

  • Authors : Xuan S; Department of Genetics and Development, College of Physicians & Surgeons, Columbia University, New York, New York, USA.; Kitamura T

Subjects: Insulin/Insulin/Insulin/*metabolism ; Islets of Langerhans/Islets of Langerhans/Islets of Langerhans/*metabolism ; Receptor, IGF Type 1/Receptor, IGF Type 1/Receptor, IGF Type 1/*physiology

  • Source: The Journal of clinical investigation [J Clin Invest] 2002 Oct; Vol. 110 (7), pp. 1011-9.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle.

  • Authors : Fernández AM; Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.; Dupont J

Subjects: Muscle, Skeletal/Muscle, Skeletal/Muscle, Skeletal/*metabolism ; Muscle, Skeletal/Muscle, Skeletal/Muscle, Skeletal/*pathology ; Receptor, IGF Type 1/Receptor, IGF Type 1/Receptor, IGF Type 1/*antagonists & inhibitors

  • Source: The Journal of clinical investigation [J Clin Invest] 2002 Feb; Vol. 109 (3), pp. 347-55.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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