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Publisher : american society for clinical investigation
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Academic Journal

Pharmacological suppression of the OTUD4/CD73 proteolytic axis revives antitumor immunity against immune-suppressive breast cancers.

  • Authors : Zhu Y; Department of Pharmacology and Chemical Biology and.; Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

Subjects: 5'-Nucleotidase*/5'-Nucleotidase*/5'-Nucleotidase*/genetics ; 5'-Nucleotidase*/5'-Nucleotidase*/5'-Nucleotidase*/immunology ; 5'-Nucleotidase*/5'-Nucleotidase*/5'-Nucleotidase*/antagonists & inhibitors

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Mar 26; Vol. 134 (10). Date of Electronic Publication: 2024 Mar 26.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Targeting a proteolytic neoepitope on CUB domain containing protein 1 (CDCP1) for RAS-driven cancers.

  • Authors : Lim SA; Department of Pharmaceutical Chemistry.; Zhou J

Subjects: Proteolysis*; Antigens, Neoplasm/Antigens, Neoplasm/Antigens, Neoplasm/*immunology ; Cell Adhesion Molecules/Cell Adhesion Molecules/Cell Adhesion Molecules/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2022 Feb 15; Vol. 132 (4).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism.

  • Authors : Mullan LA; Wellcome Trust Centre for Cell-Matrix Research.; Faculty of Biology, Medicine and Health, and Manchester Academic Health Science Centre, Manchester, United Kingdom.

Subjects: Endoplasmic Reticulum Stress* ; Mutation* ; Proteolysis*

  • Source: The Journal of clinical investigation [J Clin Invest] 2017 Oct 02; Vol. 127 (10), pp. 3861-3865. Date of Electronic Publication: 2017 Sep 18.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development.

Subjects: Proteolysis*; Acetyl-CoA Carboxylase/Acetyl-CoA Carboxylase/Acetyl-CoA Carboxylase/*metabolism ; Fatty Acids/Fatty Acids/Fatty Acids/*biosynthesis

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Jun 15; Vol. 131 (12).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy.

  • Authors : Liang Y; Department of Medicine, University of California San Diego, La Jolla, California, USA.; Lyon RC

Subjects: Proteolysis*; Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Arrhythmogenic Right Ventricular Dysplasia/Arrhythmogenic Right Ventricular Dysplasia/Arrhythmogenic Right Ventricular Dysplasia/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Jun 01; Vol. 131 (11).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias.

  • Authors : Xiao S; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, USA.; Department of Neurology, UCLA, Los Angeles, California, USA.

Subjects: Proteolysis*; Arrhythmias, Cardiac/Arrhythmias, Cardiac/Arrhythmias, Cardiac/*metabolism ; Connexin 43/Connexin 43/Connexin 43/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2020 Sep 01; Vol. 130 (9), pp. 4858-4870.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signaling.

  • Authors : Shrestha N; Department of Molecular and Integrative Physiology, University of Michigan Medical School.; Liu T

Subjects: Endoplasmic Reticulum* ; Proteolysis* ; Signal Transduction*

  • Source: The Journal of clinical investigation [J Clin Invest] 2020 Jul 01; Vol. 130 (7), pp. 3499-3510.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.

  • Authors : Liu J; Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, New Jersey, USA.; Zhang C

Subjects: Proteolysis* ; Ubiquitination*; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*enzymology

  • Source: The Journal of clinical investigation [J Clin Invest] 2020 Jun 01; Vol. 130 (6), pp. 3253-3269.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Age-dependent regulation of cell-mediated collagen turnover.

  • Authors : Podolsky MJ; Cardiovascular Research Institute.; Lung Biology Center, and.

Subjects: Proteolysis*; Aging/Aging/Aging/*metabolism ; Collagen/Collagen/Collagen/*metabolism

  • Source: JCI insight [JCI Insight] 2020 May 21; Vol. 5 (10). Date of Electronic Publication: 2020 May 21.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING.

  • Authors : Luo X; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.

Subjects: Proteolysis* ; Tumor Escape*; Head and Neck Neoplasms/Head and Neck Neoplasms/Head and Neck Neoplasms/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2020 Apr 01; Vol. 130 (4), pp. 1635-1652.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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  • 1-10 of  1,549 results for ""Proteolysis""