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Hepatocyte-derived FGL1 accelerates liver metastasis and tumor growth by inhibiting CD8+ T and NK cells.

• Authors : Xi F; Key Laboratory of Immune Response and Immunotherapy, the Institute of Immunology, Biomedical Sciences and Health Laboratory of Anhui Province, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.; Research Unit of NK Cell Study, Chinese Academy of Medical Sciences, Hefei, China.

Subjects: Killer Cells, Natural*/Killer Cells, Natural*/Killer Cells, Natural*/immunology ; CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/CD8-Positive T-Lymphocytes*/immunology ; Hepatocytes*/Hepatocytes*/Hepatocytes*/metabolism

• Source: JCI insight [JCI Insight] 2024 May 23; Vol. 9 (13). Date of Electronic Publication: 2024 May 23.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis

• Authors : Liu, Wei; Zhou, Xia; Yao, Qi

• Source: Journal of Clinical Investigation. April 15, 2023, Vol. 133 Issue 8

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Targeting FAP[alpha]-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models

• Authors : Qi, Ming; Fan, Shuran; Huang, Maohua

• Source: Journal of Clinical Investigation. October 1, 2022, Vol. 132 Issue 19

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In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis.

• Authors : Wei Liu; Xia Zhou; Qi Yao

Subjects: KUPFFER cells; LIVER metastasis; LIVER cancer

• Source: Journal of Clinical Investigation. 4/17/2023, Vol. 133 Issue 8, p1-18. 18p.

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Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.

• Authors : Qi M; Fan S; Huang M

• Source: The Journal of clinical investigation [J Clin Invest] 2023 Feb 01; Vol. 133 (3). Date of Electronic Publication: 2023 Feb 01.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Hepatic lipids promote liver metastasis.

• Authors : Li Y; Division of Anatomic and Molecular Pathology, Department of Pathology and Immunology, and.; Su X

Subjects: Lipolysis*; Liver Neoplasms/Liver Neoplasms/Liver Neoplasms/*metabolism ; Non-alcoholic Fatty Liver Disease/Non-alcoholic Fatty Liver Disease/Non-alcoholic Fatty Liver Disease/*complications

• Source: JCI insight [JCI Insight] 2020 Sep 03; Vol. 5 (17). Date of Electronic Publication: 2020 Sep 03.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis

• Authors : Ding, Qingqing; Chang, Chun-Ju; Xie, Xiaoming

• Source: Journal of Clinical Investigation. November 1, 2011, Vol. 121 Issue 11, p4526, 11 p.

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Single-cell deconvolution reveals high lineage- and location-dependent heterogeneity in mesenchymal multivisceral stage 4 colorectal cancer.

• Authors : Berlin, Christopher; Mauerer, Bernhard; Cauchy, Pierre

Subjects: COLORECTAL cancer; T-cell exhaustion; PROGNOSIS

• Source: Journal of Clinical Investigation. 3/1/2024, Vol. 134 Issue 5, p1-18. 18p.

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Targeting FAPα-expressing hepatic stellate cells overcomes resistance to antiangiogenics in colorectal cancer liver metastasis models.

• Authors : Ming Qi; Shuran Fan; Maohua Huang

Subjects: LIVER tumors; NEOVASCULARIZATION inhibitors; GROWTH factors

• Source: Journal of Clinical Investigation. 10/3/2022, Vol. 132 Issue 19, p1-18. 18p.

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APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.

• Authors : Qingqing Ding; Chun-Ju Chang; Xiaoming Xie

Subjects: LIVER metastasis; LABORATORY mice; METASTASIS

• Source: Journal of Clinical Investigation. Nov2011, Vol. 121 Issue 11, p4526-4536. 11p. 2 Color Photographs, 1 Diagram, 6 Charts, 3 Graphs.

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