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Publisher : american society for clinical investigation
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Academic Journal

Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation.

  • Authors : Persaud SP; Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology and.; Ritchey JK

Subjects: Hematopoietic Stem Cell Transplantation*; Azetidines/Azetidines/Azetidines/*pharmacology ; Immunoconjugates/Immunoconjugates/Immunoconjugates/*pharmacology

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Dec 15; Vol. 131 (24).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway.

  • Authors : Ollila S; Research Programs Unit, Faculty of Medicine and.; HiLIFE-Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.

Subjects: Cell Transformation, Neoplastic* ; Signal Transduction*; Interleukin-11/Interleukin-11/Interleukin-11/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2018 Jan 02; Vol. 128 (1), pp. 402-414. Date of Electronic Publication: 2017 Dec 04.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Selective inhibition of JAK3 signaling is sufficient to reverse alopecia areata.

  • Authors : Dai Z; Department of Dermatology and.; Chen J

Subjects: Alopecia Areata/Alopecia Areata/Alopecia Areata/*drug therapy ; Janus Kinase 3/Janus Kinase 3/Janus Kinase 3/*metabolism ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*pharmacology

  • Source: JCI insight [JCI Insight] 2021 Apr 08; Vol. 6 (7). Date of Electronic Publication: 2021 Apr 08.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Hyperactivation of JAK1 tyrosine kinase induces stepwise, progressive pruritic dermatitis.

Subjects: Dermatitis/Dermatitis/Dermatitis/*etiology ; Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*genetics ; Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2016 Jun 01; Vol. 126 (6), pp. 2064-76. Date of Electronic Publication: 2016 Apr 25.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.

  • Authors : Chan LC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.; Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Subjects: Tumor Escape*; B7-H1 Antigen/B7-H1 Antigen/B7-H1 Antigen/*immunology ; Interleukin-6/Interleukin-6/Interleukin-6/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2019 Jul 15; Vol. 129 (8), pp. 3324-3338. Date of Electronic Publication: 2019 Jul 15 (Print Publication: 2019).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

  • Authors : Bellucci R; Department of Medical Oncology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA. ; Nguyen HN

Subjects: Janus Kinase 1/Janus Kinase 1/Janus Kinase 1/*genetics ; Janus Kinase 2/Janus Kinase 2/Janus Kinase 2/*genetics ; Killer Cells, Natural/Killer Cells, Natural/Killer Cells, Natural/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2012 Jul; Vol. 122 (7), pp. 2369-83. Date of Electronic Publication: 2012 Jun 11.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.

  • Authors : Sanchez GAM; Translational Autoinflammatory Disease Section, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA.; Reinhardt A

Subjects: Azetidines/Azetidines/Azetidines/*therapeutic use ; Hereditary Autoinflammatory Diseases/Hereditary Autoinflammatory Diseases/Hereditary Autoinflammatory Diseases/*drug therapy ; Hereditary Autoinflammatory Diseases/Hereditary Autoinflammatory Diseases/Hereditary Autoinflammatory Diseases/*immunology

  • Source: The Journal of clinical investigation [J Clin Invest] 2018 Jul 02; Vol. 128 (7), pp. 3041-3052. Date of Electronic Publication: 2018 Jun 11.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Clonal hematopoiesis JAKs up plaque formation.

Subjects: Clonal Hematopoiesis*/Clonal Hematopoiesis*/Clonal Hematopoiesis*/genetics ; Janus Kinase 2*/Janus Kinase 2*/Janus Kinase 2*/genetics ; Janus Kinase 2*/Janus Kinase 2*/Janus Kinase 2*/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2025 Jan 02; Vol. 135 (1). Date of Electronic Publication: 2025 Jan 02.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice.

  • Authors : Liu W; Division of Molecular Medicine, Department of Medicine, and.; Hardaway BD

Subjects: Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/genetics ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/pathology ; Atherosclerosis*/Atherosclerosis*/Atherosclerosis*/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Nov 12; Vol. 135 (1). Date of Electronic Publication: 2024 Nov 12.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice.

  • Authors : Dodington DW; Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.; Yumol JL

Subjects: Body Size*/Body Size*/Body Size*/genetics ; Bone and Bones*/Bone and Bones*/Bone and Bones*/metabolism; Insulin-Like Growth Factor I/Insulin-Like Growth Factor I/Insulin-Like Growth Factor I/*metabolism

  • Source: JCI insight [JCI Insight] 2021 Mar 08; Vol. 6 (5). Date of Electronic Publication: 2021 Mar 08.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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  • 1-10 of  58 results for ""Janus Kinase 1""