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Academic Journal

Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery.

Subjects: *HUMAN physiology; *EARLY death; *ENDOPLASMIC reticulum

  • Source: Journal of Clinical Investigation. 1/16/2024, Vol. 134 Issue 2, p1-3. 3p.

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Academic Journal

Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders.

Subjects: CHILDREN with developmental disabilities; MISSENSE mutation; NEURAL development

  • Source: Journal of Clinical Investigation. 1/16/2024, Vol. 134 Issue 2, p1-15. 15p.

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Academic Journal

Sphingolipid desaturase DEGS1 is essential for mitochondria-associated membrane integrity.

Subjects: INBORN errors of metabolism; ENDOPLASMIC reticulum; CHOLESTEROL metabolism

  • Source: Journal of Clinical Investigation. 5/15/2023, Vol. 133 Issue 10, p1-17. 17p.

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Academic Journal

Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.

Subjects: COAT proteins (Viruses); MEMBRANE proteins; GOLGI apparatus

  • Source: Journal of Clinical Investigation. 1/3/2023, Vol. 133 Issue 1, p1-10. 10p.

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Academic Journal

Setting traps for NKG2A gives NK cell immunotherapy a fighting chance.

Subjects: *KILLER cells; *DRUM set; *ENDOPLASMIC reticulum

  • Source: Journal of Clinical Investigation. May2019, Vol. 129 Issue 5, p1839-1841. 3p.

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Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer.

Subjects: MYELOID-derived suppressor cells; VIRUS diseases; LYMPHOCYTIC choriomeningitis virus

  • Source: Journal of Clinical Investigation. 8/16/2021, Vol. 131 Issue 16, p1-14. 14p.

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Academic Journal

Endoplasmic reticulum stress sensor IRE1α propels neutrophil hyperactivity in lupus.

Subjects: ENDOPLASMIC reticulum; MITOCHONDRIAL pathology; IMMUNE complexes

  • Source: Journal of Clinical Investigation. 4/1/2021, Vol. 131 Issue 7, p1-14. 14p.

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Academic Journal

Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.

Subjects: RENAL fibrosis; ENDOPLASMIC reticulum; FIBROBLASTS

  • Source: Journal of Clinical Investigation. Mar2021, Vol. 131 Issue 5, p1-20. 21p.

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Academic Journal

The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.

Subjects: LIVER injuries; ENDOPLASMIC reticulum; ADENO-associated virus

  • Source: Journal of Clinical Investigation. 1/15/2021, Vol. 131 Issue 2, p1-14. 14p. 3 Color Photographs, 1 Diagram, 1 Chart, 5 Graphs.

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Academic Journal

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.

Subjects: ENDOPLASMIC reticulum; INDUCED pluripotent stem cells; ETIOLOGY of diabetes

  • Source: Journal of Clinical Investigation. Dec2020, Vol. 130 Issue 12, p6338-6353. 16p.

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  • 1-10 of  139 results for ""ENDOPLASMIC reticulum""