Search Results

C5 inhibition with eculizumab prevents thrombotic microangiopathy in a case series of pig-to-human kidney xenotransplantation.

• Authors : Jones-Carr, Maggie E.¹; Fatima, Huma²; Kumar, Vineeta³

Subjects: *XENOTRANSPLANTATION; *ECULIZUMAB; *KIDNEYS

• Source: Journal of Clinical Investigation. 3/1/2024, Vol. 134 Issue 5, p1-3. 3p.

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Eculizumab treatment alters the proteometabolome beyond the inhibition of complement.

• Authors : Nelke C; Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Schroeter CB

Subjects: Complement C5* ; Myasthenia Gravis*/Myasthenia Gravis*/Myasthenia Gravis*/drug therapy; Humans

• Source: JCI insight [JCI Insight] 2023 Jul 10; Vol. 8 (13). Date of Electronic Publication: 2023 Jul 10.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Complement and coagulation: key triggers of COVID-19-induced multiorgan pathology.

• Authors : Ghebrehiwet, Berhane¹ ; Peerschke, Ellinor I.²

Subjects: *COVID-19; *ECULIZUMAB; *PATHOLOGY

• Source: Journal of Clinical Investigation. Nov2020, Vol. 130 Issue 11, p5674-5676. 3p. 1 Diagram.

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PIK3CA inhibition in models of proliferative glomerulonephritis and lupus nephritis.

• Authors : Yamaguchi, Junna; Isnard, Pierre; Robil, Noémie

Subjects: LUPUS nephritis; KIDNEY failure; T cells

• Source: Journal of Clinical Investigation. 8/1/2024, Vol. 134 Issue 15, p1-20. 20p.

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DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice.

• Authors : Herman, Allison B.; Tsitsipatis, Dimitrios; Anerillas, Carlos

Subjects: ATHEROSCLEROTIC plaque; BLOOD coagulation factors; VASCULAR smooth muscle

• Source: Journal of Clinical Investigation. 6/15/2023, Vol. 133 Issue 12, p1-18. 18p.

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Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation

• Authors : Hochsmann, Britta; Murakami, Yoshiko; Osato, Makiko

• Source: Journal of Clinical Investigation. December, 2019, Vol. 129 Issue 12, p5123, 14 p.

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Microglia complement astrocytes in neuromyelitis optica

• Authors : Moinfar, Zahra; Zamvil, Scott S.

• Source: Journal of Clinical Investigation. August, 2020, Vol. 130 Issue 8, p3961, 4 p.

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COVID-19, microangiopathy, hemostatic activation, and complement

• Authors : Song, Wen-Chao; FitzGerald, Garret A.

• Source: Journal of Clinical Investigation. August, 2020, Vol. 130 Issue 8, p3950, 4 p.

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Complementopathies and precision medicine

• Authors : Gavriilaki, Eleni; Brodsky, Robert A.

• Source: Journal of Clinical Investigation. May, 2020, Vol. 130 Issue 5, p2152, 12 p.

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Reply: The importance of disrupting complement activation in acute lung injury.

• Authors : Cleary, Simon J.; Looney, Mark R.

Subjects: COMPLEMENT activation; LUNG injuries; ECULIZUMAB

• Source: Journal of Clinical Investigation. 6/17/2024, Vol. 134 Issue 12, p1-1. 1p.

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