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Academic Journal

TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation.

  • Authors : Lei Z; State Key Laboratory of Reproductive Medicine and Offspring Health, National Vaccine Innovation Platform of Nanjing Medical University, Jiangsu Key Laboratory of Pathogen Biology, Department of Pathogen Biology and Immunology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China.; Tang R

Subjects: Transforming Growth Factor beta1*/Transforming Growth Factor beta1*/Transforming Growth Factor beta1*/metabolism ; Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/genetics ; Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/metabolism

  • Source: JCI insight [JCI Insight] 2024 Mar 05; Vol. 9 (7). Date of Electronic Publication: 2024 Mar 05.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Regulation of human and mouse bystander T cell activation responses by PD-1.

  • Authors : Le CT; Department of Dermatology, School of Medicine, and.; Vick LV

Subjects: Programmed Cell Death 1 Receptor* ; Lymphocyte Activation*; Humans

  • Source: JCI insight [JCI Insight] 2023 Sep 22; Vol. 8 (18). Date of Electronic Publication: 2023 Sep 22.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling.

Subjects: Astrocytes*/Astrocytes*/Astrocytes*/metabolism ; Astrocytes*/Astrocytes*/Astrocytes*/pathology ; Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/Receptor-Interacting Protein Serine-Threonine Kinases*/metabolism

  • Source: JCI insight [JCI Insight] 2024 May 07; Vol. 9 (11). Date of Electronic Publication: 2024 May 07.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade.

  • Authors : Hayashi H; Department of Medical Oncology, Kindai University Faculty of Medicine, Osaka-Sayama, Japan.; Chamoto K

Subjects: Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/drug therapy ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/genetics ; Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/Carcinoma, Non-Small-Cell Lung*/pathology

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Apr 01; Vol. 134 (7). Date of Electronic Publication: 2024 Apr 01.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Anti-PD-1 chimeric antigen receptor T cells efficiently target SIV-infected CD4+ T cells in germinal centers.

  • Authors : Eichholz K; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Fukazawa Y

Subjects: CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/CD4-Positive T-Lymphocytes*/immunology ; Receptors, Chimeric Antigen*/Receptors, Chimeric Antigen*/Receptors, Chimeric Antigen*/genetics ; Simian Acquired Immunodeficiency Syndrome*/Simian Acquired Immunodeficiency Syndrome*/Simian Acquired Immunodeficiency Syndrome*/therapy

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Apr 01; Vol. 134 (7). Date of Electronic Publication: 2024 Apr 01.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

mTOR regulates T cell exhaustion and PD-1-targeted immunotherapy response during chronic viral infection.

  • Authors : Ando S; Division of Infectious Diseases, Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Subjects: Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/genetics ; Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/metabolism ; Virus Diseases*/Virus Diseases*/Virus Diseases*/metabolism

  • Source: The Journal of clinical investigation [J Clin Invest] 2023 Jan 17; Vol. 133 (2). Date of Electronic Publication: 2023 Jan 17.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Immunostimulatory bacterial antigen-armed oncolytic measles virotherapy significantly increases the potency of anti-PD1 checkpoint therapy.

  • Authors : Panagioti E; Department of Molecular Medicine and.; Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.

Subjects: Antigens, Bacterial/Antigens, Bacterial/Antigens, Bacterial/*therapeutic use ; Brain Neoplasms/Brain Neoplasms/Brain Neoplasms/*therapy ; Glioblastoma/Glioblastoma/Glioblastoma/*therapy

  • Source: The Journal of clinical investigation [J Clin Invest] 2021 Jul 01; Vol. 131 (13).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype.

  • Authors : Vieira V; Department of Paediatrics, University of Oxford, Oxford, United Kingdom.; Lim N

Subjects: HIV Infections* ; Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/Programmed Cell Death 1 Receptor*/metabolism; Humans

  • Source: JCI insight [JCI Insight] 2023 Feb 08; Vol. 8 (3). Date of Electronic Publication: 2023 Feb 08.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Academic Journal

PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.

  • Authors : Frijlink E; Division of Tumor Biology and Immunology and Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.; Department of Immunology and Oncode Institute, Leiden University Medical Center, Leiden, Netherlands.

Subjects: CD28 Antigens* ; Neoplasms*; Animals

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Feb 13; Vol. 134 (6). Date of Electronic Publication: 2024 Feb 13.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Academic Journal

T antigen-specific CD8+ T cells associate with PD-1 blockade response in virus-positive Merkel cell carcinoma.

  • Authors : Hansen UK; Section of Experimental and Translational Immunology, Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark.; PokeAcell Aps, BioInnovation Institute, Copenhagen, Denmark.

Subjects: Carcinoma, Merkel Cell*/Carcinoma, Merkel Cell*/Carcinoma, Merkel Cell*/drug therapy ; Carcinoma, Merkel Cell*/Carcinoma, Merkel Cell*/Carcinoma, Merkel Cell*/genetics ; Skin Neoplasms*/Skin Neoplasms*/Skin Neoplasms*/drug therapy

  • Source: The Journal of clinical investigation [J Clin Invest] 2024 Jan 30; Vol. 134 (8). Date of Electronic Publication: 2024 Jan 30.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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  • 1-10 of  1,234 results for ""Cell Death""