Search Results

B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes.

• Authors : Linsley PS; Systems Immunology Program.; Greenbaum CJ

Subjects: Abatacept/Abatacept/Abatacept/*pharmacology ; B-Lymphocytes/B-Lymphocytes/B-Lymphocytes/*metabolism ; Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/Diabetes Mellitus, Type 1/*drug therapy

• Source: JCI insight [JCI Insight] 2019 Feb 21; Vol. 4 (4). Date of Electronic Publication: 2019 Feb 21 (Print Publication: 2019).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Vascularized composite allotransplantation combined with costimulation blockade induces mixed chimerism and reveals intrinsic tolerogenic potential.

• Authors : Oh BC; Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Furtmüller GJ

Subjects: Transplantation Tolerance* ; Vascularized Composite Allotransplantation*; Abatacept/Abatacept/Abatacept/*pharmacology

• Source: JCI insight [JCI Insight] 2020 Apr 09; Vol. 5 (7). Date of Electronic Publication: 2020 Apr 09.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.

• Authors : Morano, Nicholas C.; Smith, Roshelle S.; Danelon, Victor

• Source: Journal of Clinical Investigation. 11/15/2022, Vol. 132 Issue 22, p1-16. 16p.

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Machine-learning classification identifies patients with early systemic sclerosis as abatacept responders via CD28 pathway modulation.

• Authors : Mehta BK; Department of Biomedical Data Science, Department of Molecular & Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.; Espinoza ME

Subjects: Scleroderma, Systemic*/Scleroderma, Systemic*/Scleroderma, Systemic*/drug therapy ; Scleroderma, Systemic*/Scleroderma, Systemic*/Scleroderma, Systemic*/genetics ; Scleroderma, Systemic*/Scleroderma, Systemic*/Scleroderma, Systemic*/metabolism

• Source: JCI insight [JCI Insight] 2022 Dec 22; Vol. 7 (24). Date of Electronic Publication: 2022 Dec 22.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Tregs restrain dendritic cell autophagy to ameliorate autoimmunity.

• Authors : Alissafi, Themis; Banos, Aggelos; Boon, Louis

Subjects: AUTOIMMUNE diseases; IMMUNOTHERAPY; DENDRITIC cells

• Source: Journal of Clinical Investigation. Jul2017, Vol. 127 Issue 7, p2789-2804. 16p. 7 Graphs.

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Linking erythropoietin to Treg-dependent allograft survival through myeloid cells.

• Authors : Horwitz JK; Translational Transplant Research Center and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.; Bin S

Subjects: Erythropoietin*/Erythropoietin*/Erythropoietin*/genetics ; Erythropoietin*/Erythropoietin*/Erythropoietin*/metabolism ; T-Lymphocytes, Regulatory*

• Source: JCI insight [JCI Insight] 2022 May 23; Vol. 7 (10). Date of Electronic Publication: 2022 May 23.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.

• Authors : Watkins BK; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, USA.; Tkachev V

Subjects: CD28 Antigens/CD28 Antigens/CD28 Antigens/*antagonists & inhibitors ; Graft vs Host Disease/Graft vs Host Disease/Graft vs Host Disease/*prevention & control ; T-Lymphocytes/T-Lymphocytes/T-Lymphocytes/*immunology

• Source: The Journal of clinical investigation [J Clin Invest] 2018 Aug 31; Vol. 128 (9), pp. 3991-4007. Date of Electronic Publication: 2018 Aug 13.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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Allograft dendritic cell p40 homodimers activate donor-reactive memory CD8+ T cells.

• Authors : Tsuda H; Lerner Research Institute and.; Transplant Center, Cleveland Clinic, and.

Subjects: CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*immunology ; Dendritic Cells/Dendritic Cells/Dendritic Cells/*immunology ; Graft Rejection/Graft Rejection/Graft Rejection/*immunology

• Source: JCI insight [JCI Insight] 2018 Feb 22; Vol. 3 (4). Date of Electronic Publication: 2018 Feb 22 (Print Publication: 2018).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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Selective CD28 blockade attenuates CTLA-4-dependent CD8+ memory T cell effector function and prolongs graft survival.

• Authors : Liu D; Badell IR; Ford ML

Subjects: CD28 Antigens/CD28 Antigens/CD28 Antigens/*immunology ; CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/CD8-Positive T-Lymphocytes/*immunology ; CTLA-4 Antigen/CTLA-4 Antigen/CTLA-4 Antigen/*immunology

• Source: JCI insight [JCI Insight] 2018 Jan 11; Vol. 3 (1). Date of Electronic Publication: 2018 Jan 11 (Print Publication: 2018).Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model:

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IL-7 receptor blockade following T cell depletion promotes long-term allograft survival.

• Authors : Mai HL; Boeffard F; Longis J

Subjects: Lymphocyte Depletion*; Graft Survival/Graft Survival/Graft Survival/*immunology ; Immunosuppression Therapy/Immunosuppression Therapy/Immunosuppression Therapy/*methods

• Source: The Journal of clinical investigation [J Clin Invest] 2014 Apr; Vol. 124 (4), pp. 1723-33. Date of Electronic Publication: 2014 Feb 24.Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model:

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