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PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.

• Authors : Jayappa, Kallesh D.; Tran, Brian; Gordon, Vicki L.

Subjects: CHRONIC lymphocytic leukemia; CELL death; MULTIDRUG resistance

• Source: Journal of Clinical Investigation. 7/3/2023, Vol. 133 Issue 13, p1-12. 12p.

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Lysosomal lipid peroxidation regulates tumor immunity.

• Authors : Bhardwaj, Monika; Lee, Jennifer J.; Versace, Amanda M.

Subjects: APOPTOSIS; CELL death; PEROXIDATION

• Source: Journal of Clinical Investigation. 4/17/2023, Vol. 133 Issue 8, p1-19. 19p.

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Pembrolizumab plus allogeneic NK cells in advanced non-small cell lung cancer patients

• Authors : Lin, Mao; Luo, Haihua; Liang, Shuzhen

• Source: Journal of Clinical Investigation. May, 2020, Vol. 130 Issue 5, p2560, 10 p.

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Profound MEK inhibitor response in a cutaneous melanoma harboring a GOLGA4-RAF1 fusion

• Authors : McEvoy, Christopher R.; Xu, Huiling; Smith, Kortnye

• Source: Journal of Clinical Investigation. May, 2019, Vol. 129 Issue 5, p1940, 6 p.

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Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

• Authors : Gruosso, Tina; Gigoux, Mathieu; Manem, Venkata Satya Kumar

• Source: Journal of Clinical Investigation. April, 2019, Vol. 129 Issue 4, p1785, 16 p.

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Short telomere syndromes cause a primary T cell immunodeficiency

• Authors : Wagner, Christa L.; Hanumanthu, Vidya Sagar; Talbot, C. Conover, Jr.

• Source: Journal of Clinical Investigation. December, 2018, Vol. 128 Issue 12, p5222, 13 p.

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HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.

• Authors : Singhal, Rashi; Mitta, Sreedhar R.; Das, Nupur K.

Subjects: COLORECTAL cancer; CELL death; HYPOXIA-inducible factors

• Source: Journal of Clinical Investigation. 6/15/2021, Vol. 131 Issue 12, p1-15. 15p.

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Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade.

• Authors : Sehgal, Kartik; Portell, Andrew; Ivanova, Elena V.

Subjects: PROGRAMMED cell death 1 receptors; NUCLEOTIDE sequence; RNA sequencing

• Source: Journal of Clinical Investigation. 1/15/2021, Vol. 131 Issue 2, p1-17. 17p. 1 Chart, 6 Graphs.

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Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production.

• Authors : Reinert, Line S.; Rashidi, Ahmad S.; Tran, Diana N.

Subjects: HUMAN herpesvirus 1; CELL death; APOPTOSIS

• Source: Journal of Clinical Investigation. Jan2021, Vol. 131 Issue 1, p1-17. 17p.

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Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.

• Authors : Win, Sanda; Min, Robert W. M.; Chen, Christopher Q.

Subjects: LIVER injuries; SIGNAL recognition particle receptor; PROTEIN expression

• Source: Journal of Clinical Investigation. Dec2019, Vol. 129 Issue 12, p5278-5293. 16p.

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