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Academic Journal

Podocyte-specific silencing of acid sphingomyelinase gene to abrogate hyperhomocysteinemia-induced NLRP3 inflammasome activation and glomerular inflammation.

  • Authors : Huang D; Department of Pharmacology and Toxicology, School of Medicine, Virginia Commonwealth University, Richmond, Virginia, United States.; Kidd JM

Subjects: Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/genetics ; Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/metabolism ; Podocytes*/Podocytes*/Podocytes*/metabolism

  • Source: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2024 Jun 01; Vol. 326 (6), pp. F988-F1003. Date of Electronic Publication: 2024 Apr 18.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901990 Publication Model:

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Academic Journal

Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1.

  • Authors : Ueda S; Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.; Manabe Y

Subjects: Sphingolipids*/Sphingolipids*/Sphingolipids*/metabolism ; Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/genetics ; Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/Sphingomyelin Phosphodiesterase*/metabolism

  • Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2022 May 01; Vol. 322 (5), pp. C948-C959. Date of Electronic Publication: 2022 Mar 16.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model:

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Academic Journal

Small-hairpin RNA and pharmacological targeting of neutral sphingomyelinase prevent diaphragm weakness in rats with heart failure and reduced ejection fraction.

  • Authors : Coblentz PD; Department of Applied Physiology and Kinesiology, College of Health and Human Performance, University of Florida , Gainesville, Florida.; Ahn B

Subjects: Diaphragm/Diaphragm/Diaphragm/*physiopathology ; Heart Failure/Heart Failure/Heart Failure/*physiopathology ; Muscle Weakness/Muscle Weakness/Muscle Weakness/*prevention & control

  • Source: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2019 Apr 01; Vol. 316 (4), pp. L679-L690. Date of Electronic Publication: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model:

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Academic Journal

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

  • Authors : McVey MJ; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada.; Departments of Anesthesia and Physiology, University of Toronto, and Department of Anesthesia and Pain Medicine Sickkids Hospital, Toronto, Ontario, Canada.

Subjects: Cellular Senescence*; Acute Lung Injury/Acute Lung Injury/Acute Lung Injury/*enzymology ; Acute Lung Injury/Acute Lung Injury/Acute Lung Injury/*etiology

  • Source: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2017 May 01; Vol. 312 (5), pp. L625-L637. Date of Electronic Publication: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model:

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Academic Journal

Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism.

  • Authors : Lu Z; Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.; Li Y

Subjects: Amitriptyline/Amitriptyline/Amitriptyline/*pharmacology ; Amitriptyline/Amitriptyline/Amitriptyline/*therapeutic use ; Atherosclerosis/Atherosclerosis/Atherosclerosis/*drug therapy

  • Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2020 Feb 01; Vol. 318 (2), pp. E131-E144. Date of Electronic Publication: 2019 Dec 10.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model:

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Academic Journal

Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue.

  • Authors : Ferreira LF; Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA.; Moylan JS

Subjects: Muscle Fatigue/Muscle Fatigue/Muscle Fatigue/*physiology ; Muscle, Skeletal/Muscle, Skeletal/Muscle, Skeletal/*physiology ; Oxidants/Oxidants/Oxidants/*physiology

  • Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2010 Sep; Vol. 299 (3), pp. C552-60. Date of Electronic Publication: 2010 Jun 02.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model:

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Editorial & Opinion

A novel role for sphingolipid metabolism in oxidant-mediated skeletal muscle fatigue. Focus on "Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue".

Subjects: Ceramides/Ceramides/Ceramides/*metabolism ; Muscle Fatigue/Muscle Fatigue/Muscle Fatigue/*physiology ; Muscle, Skeletal/Muscle, Skeletal/Muscle, Skeletal/*physiology

  • Source: American journal of physiology. Cell physiology [Am J Physiol Cell Physiol] 2010 Sep; Vol. 299 (3), pp. C549-51. Date of Electronic Publication: 2010 Jun 23.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901225 Publication Model:

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Academic Journal

Pancreatic trypsin cleaves intestinal alkaline sphingomyelinase from mucosa and enhances the sphingomyelinase activity.

  • Authors : Wu J; Gastroenterology Lab, Biomedical Center B11, Lund University, S-221 84 Lund, Sweden.; Liu F

Subjects: Alkalies/Alkalies/Alkalies/*metabolism ; Intestinal Mucosa/Intestinal Mucosa/Intestinal Mucosa/*enzymology ; Intestines/Intestines/Intestines/*enzymology

  • Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2004 Nov; Vol. 287 (5), pp. G967-73. Date of Electronic Publication: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model:

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Academic Journal

Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease.

  • Authors : Ikegami M; Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229, USA. ; Dhami R

Subjects: Lipoid Proteinosis of Urbach and Wiethe/Lipoid Proteinosis of Urbach and Wiethe/Lipoid Proteinosis of Urbach and Wiethe/*physiopathology ; Niemann-Pick Diseases/Niemann-Pick Diseases/Niemann-Pick Diseases/*physiopathology ; Pulmonary Alveoli/Pulmonary Alveoli/Pulmonary Alveoli/*enzymology

  • Source: American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2003 Mar; Vol. 284 (3), pp. L518-25. Date of Electronic Publication: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901229 Publication Model:

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Academic Journal

Sphingomyelinase and ceramide analogs induce contraction and rises in [Ca(2+)](i) in canine cerebral vascular muscle.

  • Authors : Zheng T; Department of Physiology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York 11203, USA.; Li W

Subjects: Basilar Artery/Basilar Artery/Basilar Artery/*metabolism ; Calcium/Calcium/Calcium/*metabolism ; Ceramides/Ceramides/Ceramides/*metabolism

  • Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2000 May; Vol. 278 (5), pp. H1421-8.Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print

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  • 1-10 of  89 results for ""Sphingomyelin Phosphodiesterase""