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Pyrimethamine Derivatives: Insight into Binding Mechanism and Improved Enhancement of Mutant β-N-acetylhexosaminidase Activity.

• Authors : Tropak MB; †Genetics and Genome Biology, SickKids, PGCRL 686 Bay Street, Toronto, Ontario M5G 0A4, Canada.; Zhang J

Subjects: Mutant Proteins/Mutant Proteins/Mutant Proteins/*metabolism ; Mutation/Mutation/Mutation/*genetics ; Pyrimethamine/Pyrimethamine/Pyrimethamine/*chemistry

• Source: Journal of medicinal chemistry [J Med Chem] 2015 Jun 11; Vol. 58 (11), pp. 4483-93. Date of Electronic Publication: 2015 Jun 02.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase.

• Authors : Chan DC; Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, UK.; Laughton CA

Subjects: Folic Acid Antagonists/Folic Acid Antagonists/Folic Acid Antagonists/*chemical synthesis ; Pneumocystis/Pneumocystis/Pneumocystis/*enzymology ; Pyrimethamine/Pyrimethamine/Pyrimethamine/*analogs & derivatives

• Source: Journal of medicinal chemistry [J Med Chem] 2001 Aug 02; Vol. 44 (16), pp. 2555-64.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited

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Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

• Authors : McKie JH; School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, U.K.; Douglas KT

Subjects: Drug Design*; Antimalarials/Antimalarials/Antimalarials/*pharmacology ; Folic Acid Antagonists/Folic Acid Antagonists/Folic Acid Antagonists/*pharmacology

• Source: Journal of medicinal chemistry [J Med Chem] 1998 Apr 23; Vol. 41 (9), pp. 1367-70.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited

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Crystal structure of β-hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone.

• Authors : Bateman KS; Department of Biochemistry, 4-29 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.; Cherney MM

Subjects: Models, Molecular*; Pyrimethamine/Pyrimethamine/Pyrimethamine/*chemistry ; beta-N-Acetylhexosaminidases/beta-N-Acetylhexosaminidases/beta-N-Acetylhexosaminidases/*chemistry

• Source: Journal of medicinal chemistry [J Med Chem] 2011 Mar 10; Vol. 54 (5), pp. 1421-9. Date of Electronic Publication: 2011 Jan 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Salt and Cocrystals Combining Sulfathiazole with Pyrimethamine.

• Authors : Bodart, Laurie; Body, Jeanne; Tumanov, Nikolay

• Source: Crystal Growth & Design; 11/1/2023, Vol. 23 Issue 11, p7811-7820, 10p

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Metal Probe Microextraction Coupled to Dielectric Barrier Discharge Ionization-Mass Spectrometry for Detecting Drug Residues in Organisms.

• Authors : Lu Q; Department of Chemistry and the MOE Key Lab of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.; Lin R

Subjects: Solid Phase Microextraction*; Drug Residues/Drug Residues/Drug Residues/*analysis ; Pyrimethamine/Pyrimethamine/Pyrimethamine/*analysis

• Source: Analytical chemistry [Anal Chem] 2020 Apr 21; Vol. 92 (8), pp. 5921-5928. Date of Electronic Publication: 2020 Mar 31.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic

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Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.

• Authors : Tarnchompoo B; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Rama 6 Road, Bangkok 10400, Thailand.; Sirichaiwat C

Subjects: Antimalarials/Antimalarials/Antimalarials/*chemical synthesis ; Folic Acid Antagonists/Folic Acid Antagonists/Folic Acid Antagonists/*chemical synthesis ; Plasmodium falciparum/Plasmodium falciparum/Plasmodium falciparum/*enzymology

• Source: Journal of medicinal chemistry [J Med Chem] 2002 Mar 14; Vol. 45 (6), pp. 1244-52.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited

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NMR studies of multiple conformations in complexes of Lactobacillus casei dihydrofolate reductase with analogues of pyrimethamine.

• Authors : Birdsall B; Laboratory of Molecular Structure, National Institute for Medical Research, London, United Kingdom.; Tendler SJ

Subjects: Lacticaseibacillus casei/Lacticaseibacillus casei/Lacticaseibacillus casei/*enzymology ; Pyrimethamine/Pyrimethamine/Pyrimethamine/*analogs & derivatives ; Pyrimethamine/Pyrimethamine/Pyrimethamine/*metabolism

• Source: Biochemistry [Biochemistry] 1990 Oct 16; Vol. 29 (41), pp. 9660-7.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited

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Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.

• Authors : Wagner CR; Department of Chemistry, Pennsylvania State University, University Park 16802.; Benkovic SJ

Subjects: Mutagenesis, Site-Directed*; Pyrimethamine/Pyrimethamine/Pyrimethamine/*pharmacology ; Tetrahydrofolate Dehydrogenase/Tetrahydrofolate Dehydrogenase/Tetrahydrofolate Dehydrogenase/*genetics

• Source: Journal of medicinal chemistry [J Med Chem] 1992 Jul 24; Vol. 35 (15), pp. 2912-5.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited

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Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

• Authors : Kamchonwongpaisan S; National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathumthani 12120, Thailand.; Quarrell R

Subjects: Antimalarials/Antimalarials/Antimalarials/*chemical synthesis ; Folic Acid Antagonists/Folic Acid Antagonists/Folic Acid Antagonists/*chemical synthesis ; Plasmodium falciparum/Plasmodium falciparum/Plasmodium falciparum/*enzymology

• Source: Journal of medicinal chemistry [J Med Chem] 2004 Jan 29; Vol. 47 (3), pp. 673-80.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited

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