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Academic Journal

The Antiproteinopathy, Antioxidant, and Antiapoptotic Effects of Methylene Blue and 4-Phenylbutyric Acid Alone, and in Combination on Familial Alzheimer's Disease PSEN1 I416T Cholinergic-Like Neurons.

  • Authors : Gomez-Sequeda N; Neuroscience Research Group, Institute of Medical Research, Faculty of Medicine, University of Antioquia, University Research Headquarters, Calle 62#52-59, Building 1, Laboratory 411/412, Medellin 050010, Colombia.; Jimenez-Del-Rio M

Subjects: Presenilin-1*/Presenilin-1*/Presenilin-1*/genetics ; Presenilin-1*/Presenilin-1*/Presenilin-1*/metabolism ; Alzheimer Disease*/Alzheimer Disease*/Alzheimer Disease*/metabolism

  • Source: ACS chemical neuroscience [ACS Chem Neurosci] 2024 Oct 02; Vol. 15 (19), pp. 3563-3575. Date of Electronic Publication: 2024 Sep 11.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic

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Academic Journal

Computing the Pathogenicity of Alzheimer's Disease Presenilin 1 Mutations.

  • Authors : Tang N; Department of Chemistry , Technical University of Denmark , DK-2800 Kongens Lyngby , Denmark.; Dehury B

Subjects: Models, Molecular* ; Mutation*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics

  • Source: Journal of chemical information and modeling [J Chem Inf Model] 2019 Feb 25; Vol. 59 (2), pp. 858-870. Date of Electronic Publication: 2019 Feb 11.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic

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Academic Journal

Tissue-Specific Metabolomics Analysis Identifies the Liver as a Major Organ of Metabolic Disorders in Amyloid Precursor Protein/Presenilin 1 Mice of Alzheimer's Disease.

  • Authors : Zheng H; Institute of Metabonomics & Medical NMR, School of Pharmaceutical Sciences , Wenzhou Medical University , Wenzhou 325035 , China.; Cai A

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics ; Brain Diseases, Metabolic/Brain Diseases, Metabolic/Brain Diseases, Metabolic/*genetics ; Liver/Liver/Liver/*metabolism

  • Source: Journal of proteome research [J Proteome Res] 2019 Mar 01; Vol. 18 (3), pp. 1218-1227. Date of Electronic Publication: 2019 Jan 09.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic

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Academic Journal

Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice.

  • Authors : Che H; College of Food Science and Engineering , Ocean University of China , Qingdao , Shandong 266003 , People's Republic of China.; Li Q

Subjects: Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*drug therapy ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*genetics ; Docosahexaenoic Acids/Docosahexaenoic Acids/Docosahexaenoic Acids/*administration & dosage

  • Source: Journal of agricultural and food chemistry [J Agric Food Chem] 2018 May 16; Vol. 66 (19), pp. 4948-4957. Date of Electronic Publication: 2018 May 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0374755 Publication Model: Print-Electronic

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Academic Journal

Membrane Dynamics of γ-Secretase Provides a Molecular Basis for β-Amyloid Binding and Processing.

  • Authors : Somavarapu AK; Technical University of Denmark , DTU Chemistry, DK-2800 Kongens Lyngby, Denmark.; Kepp KP

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*metabolism ; Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/Amyloid beta-Protein Precursor/*metabolism ; Membrane Proteins/Membrane Proteins/Membrane Proteins/*metabolism

  • Source: ACS chemical neuroscience [ACS Chem Neurosci] 2017 Nov 15; Vol. 8 (11), pp. 2424-2436. Date of Electronic Publication: 2017 Aug 25.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic

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Academic Journal

Evaluating Combined Precursor Isotopic Labeling and Isobaric Tagging Performance on Orbitraps To Study the Peripheral Proteome of Alzheimer's Disease.

  • Authors : King CD; Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.; Robinson RAS

Subjects: Isotope Labeling*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*diagnosis ; Presenilin-1/Presenilin-1/Presenilin-1/*analysis

  • Source: Analytical chemistry [Anal Chem] 2020 Feb 18; Vol. 92 (4), pp. 2911-2916. Date of Electronic Publication: 2020 Jan 27.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic

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Academic Journal

Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations.

  • Authors : Quintero-Monzon O; Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.; Martin MM

Subjects: Mutagenesis, Site-Directed*; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*enzymology ; Alzheimer Disease/Alzheimer Disease/Alzheimer Disease/*genetics

  • Source: Biochemistry [Biochemistry] 2011 Oct 25; Vol. 50 (42), pp. 9023-35. Date of Electronic Publication: 2011 Sep 30.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic

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Academic Journal

Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.

  • Authors : Takagi-Niidome S; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.; Osawa S

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Antibodies, Monoclonal/Antibodies, Monoclonal/Antibodies, Monoclonal/*immunology ; Antibodies, Monoclonal/Antibodies, Monoclonal/Antibodies, Monoclonal/*pharmacology

  • Source: Biochemistry [Biochemistry] 2013 Jan 08; Vol. 52 (1), pp. 61-9. Date of Electronic Publication: 2012 Dec 14.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic

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Academic Journal

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes.

  • Authors : Lee J; Department of Neuroscience, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States.; Song L

Subjects: Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/Amyloid Precursor Protein Secretases/*antagonists & inhibitors ; Cyclic S-Oxides/Cyclic S-Oxides/Cyclic S-Oxides/*chemistry ; Enzyme Inhibitors/Enzyme Inhibitors/Enzyme Inhibitors/*chemistry

  • Source: Biochemistry [Biochemistry] 2011 Jun 07; Vol. 50 (22), pp. 4973-80. Date of Electronic Publication: 2011 May 13.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic

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Academic Journal

Novel role of presenilins in maturation and transport of integrin beta 1.

  • Authors : Zou K; Department of Alzheimer's Disease Research, National Institute for Longevity Sciences, NCGG, 36-3 Gengo, Morioka, Obu, Aichi 474-8522, Japan. ; Hosono T

Subjects: Integrin beta1/Integrin beta1/Integrin beta1/*metabolism ; Presenilin-1/Presenilin-1/Presenilin-1/*physiology ; Presenilin-2/Presenilin-2/Presenilin-2/*physiology

  • Source: Biochemistry [Biochemistry] 2008 Mar 18; Vol. 47 (11), pp. 3370-8. Date of Electronic Publication: 2008 Feb 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic

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  • 1-10 of  120 results for ""Presenilin-1""