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Design and Synthesis of Novel 3-Nitro-1 H -1,2,4-triazole-1,2,3-triazole-1,4-disubstituted Analogs as Promising Antitrypanosomatid Agents: Evaluation of In Vitro Activity against Chagas Disease and Leishmaniasis.

• Authors : Pelizaro BI; Laboratório de Síntese e Química Medicinal (LASQUIM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição, Universidade Federal de Mato Grossso do Sul- UFMS, Campo Grande, Mato Grosso do Sul CEP 79070-900, Brazil.; Batista JCZ

Subjects: Trypanocidal Agents* ; Chagas Disease*/Chagas Disease*/Chagas Disease*/drug therapy ; Trypanosoma cruzi*

• Source: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2584-2601. Date of Electronic Publication: 2024 Feb 02.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis.

• Authors : Exertier C; Institute of Molecular Biology and Pathology (IBPM) of the National Research Council of Italy (CNR), c/o Department of Biochemical Sciences, Sapienza University of Rome, Piazzale A. Moro 5, Roma 00185, Italy.; Salerno A

Subjects: Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/pharmacology ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/therapeutic use ; Enzyme Inhibitors*/Enzyme Inhibitors*/Enzyme Inhibitors*/chemistry

• Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 11; Vol. 67 (1), pp. 402-419. Date of Electronic Publication: 2024 Jan 02.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Optimization of Orally Bioavailable Antileishmanial 2,4,5-Trisubstituted Benzamides.

• Authors : Kim HS; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0509 United States.; Ortiz D

Subjects: Leishmania* ; Leishmaniasis*/Leishmaniasis*/Leishmaniasis*/drug therapy ; Leishmaniasis*/Leishmaniasis*/Leishmaniasis*/chemically induced

• Source: Journal of medicinal chemistry [J Med Chem] 2023 Jun 08; Vol. 66 (11), pp. 7374-7386. Date of Electronic Publication: 2023 May 22.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Novel Pyrido[2',1':2,3]imidazo[4,5- c ]quinoline Derivative Selectively Poisons Leishmania donovani Bisubunit Topoisomerase 1 to Inhibit the Antimony-Resistant Leishmania Infection in Vivo .

• Authors : Chowdhuri SP; Laboratory of Molecular Biology, School of Biological Sciences, Indian Association for the Cultivation of Science, 2A & B, Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, India.; Dhiman S

Subjects: Leishmania donovani* ; Leishmaniasis, Visceral*/Leishmaniasis, Visceral*/Leishmaniasis, Visceral*/drug therapy ; Leishmaniasis, Visceral*/Leishmaniasis, Visceral*/Leishmaniasis, Visceral*/parasitology

• Source: Journal of medicinal chemistry [J Med Chem] 2023 Mar 09; Vol. 66 (5), pp. 3411-3430. Date of Electronic Publication: 2023 Feb 23.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Synchrotron-Infrared Microspectroscopy of Live Leishmania major Infected Macrophages and Isolated Promastigotes and Amastigotes.

• Authors : Chakkumpulakkal Puthan Veettil T; Centre for Biospectroscopy, School of Chemistry, Faculty of Science, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.; Duffin RN

Subjects: Leishmania major* ; Leishmaniasis*/Leishmaniasis*/Leishmaniasis*/diagnosis; Animals

• Source: Analytical chemistry [Anal Chem] 2023 Feb 28; Vol. 95 (8), pp. 3986-3995. Date of Electronic Publication: 2023 Feb 14.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic

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Thiolated PVP-Amphotericin B Complexes: An Innovative Approach toward Highly Mucoadhesive Gels for Mucosal Leishmaniasis Treatment.

• Authors : Jalil A; Center for Chemistry and Biomedicine, Department of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innrain 80/82, 6020 Innsbruck, Austria.; Asim MH

Subjects: Leishmaniasis* ; Povidone*; Amphotericin B/Amphotericin B/Amphotericin B/pharmacology

• Source: Biomacromolecules [Biomacromolecules] 2020 Sep 14; Vol. 21 (9), pp. 3658-3667. Date of Electronic Publication: 2020 Aug 17.Publisher: American Chemical Society Country of Publication: United States NLM ID: 100892849 Publication Model: Print-Electronic

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A Targeted and Protease-Activated Genetically Encoded Melittin-Containing Particle for the Treatment of Cutaneous and Visceral Leishmaniasis.

• Authors : Habib, Madiha; Zheng, Jiale; Chan, Chin-Fung

• Source: ACS Applied Materials & Interfaces; 9/18/2024, Vol. 16 Issue 37, p49148-49163, 16p

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Interaction of KMP-11 with Phospholipid Membranes and Its Implications in Leishmaniasis: Effects of Single Tryptophan Mutations and Cholesterol.

• Authors : Sannigrahi A; Structural Biology & Bio-Informatics Division, CSIR-Indian Institute of Chemical Biology , 4, Raja S. C. Mallick Road, Kolkata 700032, India.; Maity P

Subjects: Cholesterol/Cholesterol/Cholesterol/*metabolism ; Leishmania/Leishmania/Leishmania/*physiology ; Leishmaniasis/Leishmaniasis/Leishmaniasis/*metabolism

• Source: The journal of physical chemistry. B [J Phys Chem B] 2017 Mar 02; Vol. 121 (8), pp. 1824-1834. Date of Electronic Publication: 2017 Feb 22.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic

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Metabolic Clustering Analysis as a Strategy for Compound Selection in the Drug Discovery Pipeline for Leishmaniasis.

• Authors : Armitage EG; Centre for Metabolomics and Bioanalysis (CEMBIO) , Facultad de Farmacia, Universidad CEU San Pablo , Campus Montepríncipe, Boadilla del Monte , 28668 Madrid , Spain.; GSK I+D Diseases of the Developing World (DDW), Parque Tecnológico de Madrid , Calle de Severo Ochoa 2 , 28760 Tres Cantos, Madrid , Spain.

Subjects: Drug Discovery*; Antiprotozoal Agents/Antiprotozoal Agents/Antiprotozoal Agents/*therapeutic use ; Leishmaniasis/Leishmaniasis/Leishmaniasis/*drug therapy

• Source: ACS chemical biology [ACS Chem Biol] 2018 May 18; Vol. 13 (5), pp. 1361-1369. Date of Electronic Publication: 2018 Apr 24.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic

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Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review.

• Authors : Tambe, Srushti; Nag, Sagnik; Pandya, Shivani R.

• Source: ACS Infectious Diseases; 6/14/2024, Vol. 10 Issue 6, p1871-1889, 19p

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