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Academic Journal

Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions.

  • Authors : Popow J; Boehringer Ingelheim RCV GmbH & Co KG , 1221 Vienna , Austria.; Arnhof H

Subjects: Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/*drug effects ; Focal Adhesion Protein-Tyrosine Kinases/Focal Adhesion Protein-Tyrosine Kinases/Focal Adhesion Protein-Tyrosine Kinases/*metabolism ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2019 Mar 14; Vol. 62 (5), pp. 2508-2520. Date of Electronic Publication: 2019 Feb 22.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Academic Journal

Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation.

  • Authors : Cromm PM; Department of Molecular, Cellular & Developmental Biology , Yale University , New Haven , Connecticut 06511 , United States.; Samarasinghe KTG

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*pharmacology ; Benzamides/Benzamides/Benzamides/*pharmacology ; Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/*antagonists & inhibitors

  • Source: Journal of the American Chemical Society [J Am Chem Soc] 2018 Dec 12; Vol. 140 (49), pp. 17019-17026. Date of Electronic Publication: 2018 Nov 28.Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic

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Academic Journal

Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK).

  • Authors : Ott GR; Teva Branded Pharmaceutical Products R&D , 145 Brandywine Parkway, West Chester, Pennsylvania 19380, United States.; Cheng M

Subjects: Drug Discovery*; Benzamides/Benzamides/Benzamides/*pharmacology ; Benzocycloheptenes/Benzocycloheptenes/Benzocycloheptenes/*pharmacology

  • Source: Journal of medicinal chemistry [J Med Chem] 2016 Aug 25; Vol. 59 (16), pp. 7478-96. Date of Electronic Publication: 2016 Aug 15.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Academic Journal

Nanofibers Regulate Single Bone Marrow Stem Cell Osteogenesis via FAK/RhoA/YAP1 Pathway.

  • Authors : Chang B; Department of Biomedical Sciences , Texas A&M University College of Dentistry , Dallas , Texas 75246 , United States.; Ma C

Subjects: Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/Adaptor Proteins, Signal Transducing/*metabolism ; Bone Marrow Cells/Bone Marrow Cells/Bone Marrow Cells/*cytology ; Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/*metabolism

  • Source: ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2018 Oct 03; Vol. 10 (39), pp. 33022-33031. Date of Electronic Publication: 2018 Sep 18.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic

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Academic Journal

Structural Insights How PIP2 Imposes Preferred Binding Orientations of FAK at Lipid Membranes.

  • Authors : Herzog FA; Laboratory of Applied Mechanobiology, Department of Health Sciences and Technology, ETH Zürich , 8093 Zürich, Switzerland.; Braun L

Subjects: Molecular Dynamics Simulation*; Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/*chemistry ; Lipid Bilayers/Lipid Bilayers/Lipid Bilayers/*chemistry

  • Source: The journal of physical chemistry. B [J Phys Chem B] 2017 Apr 20; Vol. 121 (15), pp. 3523-3535. Date of Electronic Publication: 2017 Feb 10.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101157530 Publication Model: Print-Electronic

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Academic Journal

Bisphenol A Induces Migration through a GPER-, FAK-, Src-, and ERK2-Dependent Pathway in MDA-MB-231 Breast Cancer Cells.

  • Authors : Castillo Sanchez R; Departamento de Toxicologia, ‡Departamento de Biologia Celular, Cinvestav-IPN , Mexico D.F., Mexico.; Gomez R

Subjects: Benzhydryl Compounds/Benzhydryl Compounds/Benzhydryl Compounds/*pharmacology ; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*metabolism ; Breast Neoplasms/Breast Neoplasms/Breast Neoplasms/*pathology

  • Source: Chemical research in toxicology [Chem Res Toxicol] 2016 Mar 21; Vol. 29 (3), pp. 285-95. Date of Electronic Publication: 2016 Mar 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic

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Academic Journal

Kinetic mechanism and rate-limiting steps of focal adhesion kinase-1.

  • Authors : Schneck JL; Department of Biological Reagents, GlaxoSmithKline Pharmaceuticals, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426-0989, USA.; Briand J

Subjects: Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/*chemistry ; Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/Focal Adhesion Kinase 1/*metabolism ; Peptides/Peptides/Peptides/*metabolism

  • Source: Biochemistry [Biochemistry] 2010 Aug 24; Vol. 49 (33), pp. 7151-63.Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited

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Academic Journal

Hydroxyapatite Nanoparticles Promote the Development of Bone Microtissues for Accelerated Bone Regeneration by Activating the FAK/Akt Pathway.

  • Authors : Li L; Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai 200040, China.; Department of Orthopedics, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.

Subjects: Durapatite*/Durapatite*/Durapatite*/chemistry ; Durapatite*/Durapatite*/Durapatite*/pharmacology ; Bone Regeneration*/Bone Regeneration*/Bone Regeneration*/drug effects

  • Source: ACS biomaterials science & engineering [ACS Biomater Sci Eng] 2024 Jul 08; Vol. 10 (7), pp. 4463-4479. Date of Electronic Publication: 2024 Jun 07.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic

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Academic Journal

Identification of Thieno[3,2- d ]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.

  • Authors : Cho H; Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.; Shin I

Subjects: Antineoplastic Agents/Antineoplastic Agents/Antineoplastic Agents/*therapeutic use ; Neoplasms/Neoplasms/Neoplasms/*drug therapy ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*therapeutic use

  • Source: Journal of medicinal chemistry [J Med Chem] 2021 Aug 26; Vol. 64 (16), pp. 11934-11957. Date of Electronic Publication: 2021 Jul 29.Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic

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Academic Journal

Design, Synthesis, Biological Evaluation, and Molecular Docking of 2,4-Diaminopyrimidine Derivatives Targeting Focal Adhesion Kinase as Tumor Radiotracers.

  • Authors : Qi Y; College of Chemistry, Beijing Normal University, No. 19 Xinjiekouwai Street, Haidian District, Beijing 100875, China.; Li Y

Subjects: Neoplasms/Neoplasms/Neoplasms/*diagnosis ; Positron-Emission Tomography/Positron-Emission Tomography/Positron-Emission Tomography/*methods ; Protein Kinase Inhibitors/Protein Kinase Inhibitors/Protein Kinase Inhibitors/*administration & dosage

  • Source: Molecular pharmaceutics [Mol Pharm] 2021 Apr 05; Vol. 18 (4), pp. 1634-1642. Date of Electronic Publication: 2021 Mar 19.Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic

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  • 1-10 of  27 results for ""Focal Adhesion Kinase 1""