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Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV‑2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants.

• Authors : Wang, Xu; Gotchev, Dimitar; Fan, Kristi Yi

• Source: Journal of Medicinal Chemistry; 11/14/2024, Vol. 67 Issue 21, p19623-19667, 45p

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Frequency-Domain Low-Wavenumber Hyperspectral Stimulated Raman Scattering Microscopy.

• Authors : Clark, Matthew G.; Mohn, Karsten J.; Dong, Bin

• Source: Analytical Chemistry; 6/25/2024, Vol. 96 Issue 25, p10341-10347, 7p

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Development of Potent Mcl‑1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.

• Authors : Hekking, Koen F. W.; Maroto, Sergio; van Kekem, Kees

• Source: Journal of Medicinal Chemistry; 2/22/2024, Vol. 678 Issue 4, p3039-3065, 27p

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Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity.

• Authors : Collie, Gavin W.; Clark, Matthew A.; Keefe, Anthony D.

• Source: Journal of Medicinal Chemistry; 1/25/2024, Vol. 67 Issue 2, p864-884, 21p

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Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning.

• Authors : Ahmad, Shabbir; Xu, Jin; Feng, Jianwen A.

• Source: Journal of Medicinal Chemistry; 12/14/2023, Vol. 66 Issue 23, p16051-16061, 11p

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Pulse-Picking Multimodal Nonlinear Optical Microscopy.

• Authors : Clark, Matthew G.; Gonzalez, Gil A.; Zhang, Chi

• Source: Analytical Chemistry; 11/8/2022, Vol. 94 Issue 44, p15405-15414, 10p

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Applied Science & Technology Full Text (H.W. Wilson)

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Generating Selective Leads for Mer Kinase InhibitorsExample of a Comprehensive Lead-Generation Strategy.

• Authors : Nissink, J. Willem M.; Bazzaz, Sana; Blackett, Carolyn

• Source: Journal of Medicinal Chemistry; 3/25/2021, Vol. 64 Issue 6, p3165-3184, 20p

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Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.

• Authors : McCloskey, Kevin; Sigel, Eric A.; Kearnes, Steven

• Source: Journal of Medicinal Chemistry; 8/27/2020, Vol. 63 Issue 16, p8857-8866, 10p

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Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry.

• Authors : Cuozzo, John W.; Clark, Matthew A.; Keefe, Anthony D.

• Source: Journal of Medicinal Chemistry; 7/23/2020, Vol. 63 Issue 14, p7840-7856, 17p

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