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Academic Journal

Is It Time to Use Modeling of Cellular Transporter Homeostasis to Inform Drug-Drug Interaction Studies: Theoretical Considerations.

  • Authors : Abbiati RA; Institute of Quantitative Systems Pharmacology, Carlsbad, California, 92008, USA.; Department of Pharmaceutical Sciences, University of Oklahoma, Oklahoma City, Oklahoma, 73117, USA.

Subjects: Drug Interactions* ; Models, Biological*; Drug Development/Drug Development/Drug Development/*methods

  • Source: The AAPS journal [AAPS J] 2021 Aug 25; Vol. 23 (5), pp. 102. Date of Electronic Publication: 2021 Aug 25.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication

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Academic Journal

Cell-to-Medium Concentration Ratio Overshoot in the Uptake of Statins by Human Hepatocytes in Suspension, but Not in Monolayer: Kinetic Analysis Suggesting a Partial Loss of Functional OATP1Bs.

  • Authors : Lee W; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, South Korea.; Koyama S

Subjects: Hepatocytes/Hepatocytes/Hepatocytes/*enzymology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacokinetics ; Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/Liver-Specific Organic Anion Transporter 1/*metabolism

  • Source: The AAPS journal [AAPS J] 2020 Oct 15; Vol. 22 (6), pp. 133. Date of Electronic Publication: 2020 Oct 15.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication

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Academic Journal

Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data.

  • Authors : Li R; Systems Modeling and Simulation, Medicine Design, Pfizer Worldwide R&D, Cambridge, Massachusetts, 02139, USA. .

Subjects: Models, Genetic* ; Polymorphism, Single Nucleotide*; Liver/Liver/Liver/*metabolism

  • Source: The AAPS journal [AAPS J] 2019 May 28; Vol. 21 (4), pp. 69. Date of Electronic Publication: 2019 May 28.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication

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Academic Journal

Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist).

  • Authors : Sandoval P; Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), 95 Hayden Avenue, Lexington, Massachusetts, 02421, USA.; Chuang BC

Subjects: Bile*/Bile*/Bile*/metabolism ; Organic Anion Transporters*/Organic Anion Transporters*/Organic Anion Transporters*/metabolism; Animals

  • Source: The AAPS journal [AAPS J] 2022 Sep 19; Vol. 24 (6), pp. 99. Date of Electronic Publication: 2022 Sep 19.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication

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Academic Journal

Optimization and Application of a Biotinylation Method for Quantification of Plasma Membrane Expression of Transporters in Cells.

  • Authors : Kumar V; Department of Pharmaceutics, University of Washington, P. O. Box 357610, Seattle, Washington, 98195, USA.; Nguyen TB

Subjects: Biotinylation/Biotinylation/Biotinylation/*methods ; Cell Membrane/Cell Membrane/Cell Membrane/*chemistry ; Membrane Transport Proteins/Membrane Transport Proteins/Membrane Transport Proteins/*analysis

  • Source: The AAPS journal [AAPS J] 2017 Sep; Vol. 19 (5), pp. 1377-1386. Date of Electronic Publication: 2017 Jul 24.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication

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Academic Journal

Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.

  • Authors : Yoshida K; Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo Japan.; Takano J

Subjects: Polymorphism, Single Nucleotide*; High-Throughput Nucleotide Sequencing/High-Throughput Nucleotide Sequencing/High-Throughput Nucleotide Sequencing/*methods ; Organic Anion Transporters/Organic Anion Transporters/Organic Anion Transporters/*genetics

  • Source: The AAPS journal [AAPS J] 2013 Apr; Vol. 15 (2), pp. 618-22. Date of Electronic Publication: 2013 Mar 08.Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication

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  • 1-6 of  6 results for ""Liver-Specific Organic Anion Transporter 1""