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Academic Journal

A glutamine metabolic switch supports erythropoiesis.

  • Authors : Lyu J; Center of Excellence for Leukemia Studies, Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Gu Z

Subjects: Ammonium Compounds*/Ammonium Compounds*/Ammonium Compounds*/metabolism ; beta-Thalassemia*/beta-Thalassemia*/beta-Thalassemia*/metabolism ; beta-Thalassemia*/beta-Thalassemia*/beta-Thalassemia*/genetics

  • Source: Science (New York, N.Y.) [Science] 2024 Nov 15; Vol. 386 (6723), pp. eadh9215. Date of Electronic Publication: 2024 Nov 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans.

  • Authors : Fiorenza M; August Krogh Section for Human Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen 2100, Denmark.; Department of Biomedical Sciences, University of Copenhagen, Copenhagen 2200, Denmark.

Subjects: Insulin Resistance* ; Muscle, Skeletal*/Muscle, Skeletal*/Muscle, Skeletal*/metabolism ; Muscle, Skeletal*/Muscle, Skeletal*/Muscle, Skeletal*/drug effects

  • Source: Science advances [Sci Adv] 2024 Nov; Vol. 10 (44), pp. eadq4461. Date of Electronic Publication: 2024 Oct 30.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Editorial & Opinion

The Goldilocks effect of glial tau.

  • Authors : Ferrarelli LK; Science Signaling, AAAS, Washington, DC 20005, USA.

Subjects: Neuroglia*/Neuroglia*/Neuroglia*/metabolism ; Oxidative Stress* ; tau Proteins*/tau Proteins*/tau Proteins*/metabolism

  • Source: Science signaling [Sci Signal] 2024 Oct 15; Vol. 17 (858), pp. eadt7163. Date of Electronic Publication: 2024 Oct 15.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication

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Academic Journal

LRRK2 regulates production of reactive oxygen species in cell and animal models of Parkinson's disease.

  • Authors : Keeney MT; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Subjects: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/metabolism ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/Leucine-Rich Repeat Serine-Threonine Protein Kinase-2*/genetics ; Reactive Oxygen Species*/Reactive Oxygen Species*/Reactive Oxygen Species*/metabolism

  • Source: Science translational medicine [Sci Transl Med] 2024 Oct 02; Vol. 16 (767), pp. eadl3438. Date of Electronic Publication: 2024 Oct 02.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

Micronuclear collapse mechanisms in cancer.

  • Authors : Maddaluno M; Telethon Institute of Genetics and Medicine (TIGEM), Pozzuoli, Italy.; Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.

Subjects: Neoplasms*/Neoplasms*/Neoplasms*/genetics ; Oxidative Stress*; Humans

  • Source: Science (New York, N.Y.) [Science] 2024 Aug 30; Vol. 385 (6712), pp. 930-931. Date of Electronic Publication: 2024 Aug 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Micronuclear collapse from oxidative damage.

  • Authors : Di Bona M; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Subjects: Endosomal Sorting Complexes Required for Transport*/Endosomal Sorting Complexes Required for Transport*/Endosomal Sorting Complexes Required for Transport*/metabolism ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/metabolism ; Membrane Proteins*/Membrane Proteins*/Membrane Proteins*/genetics

  • Source: Science (New York, N.Y.) [Science] 2024 Aug 30; Vol. 385 (6712), pp. eadj8691. Date of Electronic Publication: 2024 Aug 30.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication

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Academic Journal

Phase-changing citrate macromolecule combats oxidative pancreatic islet damage, enables islet engraftment and function in the omentum.

  • Authors : Burke JA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.; Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208, USA.

Subjects: Islets of Langerhans Transplantation*/Islets of Langerhans Transplantation*/Islets of Langerhans Transplantation*/methods ; Omentum*/Omentum*/Omentum*/metabolism ; Islets of Langerhans*/Islets of Langerhans*/Islets of Langerhans*/metabolism

  • Source: Science advances [Sci Adv] 2024 Jun 07; Vol. 10 (23), pp. eadk3081. Date of Electronic Publication: 2024 Jun 07.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication

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Academic Journal

Replenishing IRAK-M expression in retinal pigment epithelium attenuates outer retinal degeneration.

  • Authors : Liu J; Academic Unit of Ophthalmology, Bristol Medical School, University of Bristol, Bristol BS8 1TD, UK.; Copland DA

Subjects: Interleukin-1 Receptor-Associated Kinases*/Interleukin-1 Receptor-Associated Kinases*/Interleukin-1 Receptor-Associated Kinases*/metabolism ; Interleukin-1 Receptor-Associated Kinases*/Interleukin-1 Receptor-Associated Kinases*/Interleukin-1 Receptor-Associated Kinases*/genetics ; Mice, Knockout*

  • Source: Science translational medicine [Sci Transl Med] 2024 Jun 05; Vol. 16 (750), pp. eadi4125. Date of Electronic Publication: 2024 Jun 05.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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Academic Journal

ULK1 inhibition promotes oxidative stress-induced differentiation and sensitizes leukemic stem cells to targeted therapy.

  • Authors : Ianniciello A; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.; Zarou MM

Subjects: Autophagy* ; Oxidative Stress*; Autophagy-Related Protein-1 Homolog/Autophagy-Related Protein-1 Homolog/Autophagy-Related Protein-1 Homolog/metabolism

  • Source: Science translational medicine [Sci Transl Med] 2021 Sep 29; Vol. 13 (613), pp. eabd5016. Date of Electronic Publication: 2021 Sep 29.Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication

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